Changes in Extracellular Matrix and in Transforming Growth Factor Beta Isoforms After Coronary Artery Ligation in Rats

Extensive myocardial remodeling occurs after transmural myocardial infarction (MI). The infarcted myocardium is being replaced by scar tissue after gradual resorption of the necrotic tissue. The remodeling process involves both synthesis and degradation of collagens as major components of the extrac...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2001-06, Vol.33 (6), p.1191-1207
Hauptverfasser:	Deten, Alexander, Hölzl, Alexander, Leicht, Monika, Barth, Wilfried, Zimmer, Heinz-Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries Carrier Proteins - genetics Carrier Proteins - metabolism Collagen - genetics Collagen metabolism Colligin Coronary Vessels Extracellular Matrix - metabolism Female Gelatin - metabolism Gene Expression Hemodynamics Hypertrophy, Right Ventricular - metabolism Hypertrophy, Right Ventricular - physiopathology Matrix metalloproteinase Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 8 - genetics Matrix Metalloproteinase 8 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocardium - metabolism Protein Isoforms - genetics Rats Rats, Sprague-Dawley Remodeling RNA, Messenger Tissue Inhibitor of Metalloproteinase-2 - genetics Transforming growth factor Transforming Growth Factor beta - genetics Transforming Growth Factor beta1 Transforming Growth Factor beta2 Transforming Growth Factor beta3 Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Right - metabolism Ventricular Dysfunction, Right - physiopathology Wound healing
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