BMP-7-induced cell cycle arrest of anaplastic thyroid carcinoma cells via p21(CIP1) and p27(KIP1)

The aim of the present study was to investigate the effect of bone morphogenetic protein (BMP-7) on thyroid carcinoma cell growth. Addition of BMP-7 inhibited the proliferation of four out of six human anaplastic thyroid carcinoma cell lines, observed as decreased incorporation of (3)H-thymidine and...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-07, Vol.285 (3), p.773-781
Hauptverfasser:	Franzén A, Heldin, N E
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - pharmacology Carcinoma - metabolism Carcinoma - pathology CDC2-CDC28 Kinases Cell Count Cell Cycle - drug effects Cell Cycle Proteins - metabolism Cell Division - drug effects Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - metabolism Cyclins - metabolism Dose-Response Relationship, Drug Flow Cytometry G1 Phase - drug effects Humans Phosphorylation - drug effects Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins Retinoblastoma Protein - metabolism Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Transforming Growth Factor beta Tumor Cells, Cultured Tumor Suppressor Proteins Up-Regulation - drug effects
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