Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus
Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with circulating antibodies that bind the cell surface of the epidermis and other non‐stratifying epithelia, and immunoprecipitate a complex of four or five proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa)....
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| Veröffentlicht in: | British journal of dermatology (1951) 2000-03, Vol.142 (3), p.506-508 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 142 |
| creator | Williams, J.V. Marks JR, J.G. Billingsley, E.M. |
| description | Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with circulating antibodies that bind the cell surface of the epidermis and other non‐stratifying epithelia, and immunoprecipitate a complex of four or five proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa). 1,2 Combinations of immunosuppressive agents are usually required to obtain even partial control of the skin lesions.
3 Mucous membrane lesions are refractory to treatment. We describe a patient with PNP whose skin and oral lesions are quiescent following treatment with oral mycophenolate mofetil. |
| doi_str_mv | 10.1046/j.1365-2133.2000.03365.x |
| format | Article |
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3 Mucous membrane lesions are refractory to treatment. We describe a patient with PNP whose skin and oral lesions are quiescent following treatment with oral mycophenolate mofetil.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1046/j.1365-2133.2000.03365.x</identifier><identifier>PMID: 10735959</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Biological and medical sciences ; Bullous diseases of the skin ; Chemotherapy, Adjuvant ; Dermatology ; Female ; Humans ; Immunosuppressive Agents - therapeutic use ; Medical sciences ; Mouth Mucosa - pathology ; mycophenolate mofetil ; Mycophenolic Acid - analogs & derivatives ; Mycophenolic Acid - therapeutic use ; paraneoplastic pemphigus ; Paraneoplastic Syndromes - diagnosis ; Paraneoplastic Syndromes - drug therapy ; Paraneoplastic Syndromes - pathology ; Pemphigus - diagnosis ; Pemphigus - drug therapy ; Pemphigus - pathology ; Precipitin Tests ; Prodrugs - therapeutic use ; Treatment Outcome</subject><ispartof>British journal of dermatology (1951), 2000-03, Vol.142 (3), p.506-508</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Mar 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4875-2d698a24f60929ff43a7538bf8266c48dff4803fb9789479b219ad1b941032123</citedby><cites>FETCH-LOGICAL-c4875-2d698a24f60929ff43a7538bf8266c48dff4803fb9789479b219ad1b941032123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2133.2000.03365.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2133.2000.03365.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,778,782,787,788,1414,23913,23914,25123,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1303922$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10735959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, J.V.</creatorcontrib><creatorcontrib>Marks JR, J.G.</creatorcontrib><creatorcontrib>Billingsley, E.M.</creatorcontrib><title>Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with circulating antibodies that bind the cell surface of the epidermis and other non‐stratifying epithelia, and immunoprecipitate a complex of four or five proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa). 1,2 Combinations of immunosuppressive agents are usually required to obtain even partial control of the skin lesions.
3 Mucous membrane lesions are refractory to treatment. We describe a patient with PNP whose skin and oral lesions are quiescent following treatment with oral mycophenolate mofetil.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bullous diseases of the skin</subject><subject>Chemotherapy, Adjuvant</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Medical sciences</subject><subject>Mouth Mucosa - pathology</subject><subject>mycophenolate mofetil</subject><subject>Mycophenolic Acid - analogs & derivatives</subject><subject>Mycophenolic Acid - therapeutic use</subject><subject>paraneoplastic pemphigus</subject><subject>Paraneoplastic Syndromes - diagnosis</subject><subject>Paraneoplastic Syndromes - drug therapy</subject><subject>Paraneoplastic Syndromes - pathology</subject><subject>Pemphigus - diagnosis</subject><subject>Pemphigus - drug therapy</subject><subject>Pemphigus - pathology</subject><subject>Precipitin Tests</subject><subject>Prodrugs - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQhi0EoqXwCihCiFvC2M5iHzhA2VWJCz1bTmLTVNmIE9G-PTapAHHi5GW-Gf_-EPIwBBjC-HIdYBpHPsGUBgQAAqD2HGz20PS7sI-mtpL4wGM6QUfGrAEwhQgO0QRDQiMe8Sl6WhrlNdqrtlnTrlTdlLJXXtVo1RelV9Rev1Je3ynZV6ruHdnKTtaqaUtp-iLzWlW1q-JtMMfoQMvSqJPdOkPL-7vX-aO_eHl4ml8v_CxkiY2Wx5xJEuoYOOFah1QmEWWpZiSOLZLbKwZUpzxhPEx4SjCXOU55iIESTOgMXYxz2655H5TpRVWYTJWlSzUYkQDnMYmoBc_-gOtm6GqbTVhnmOCEYQuxEcq6xphOadF2RSW7rcAgnGuxFk6pcEpdH4gv12JjW09384e0UvmvxlGuBc53gDSZLLX1lhXmh6NAOXEfuhqxj6JU23-_L26eb92OfgIxeJfr</recordid><startdate>200003</startdate><enddate>200003</enddate><creator>Williams, J.V.</creator><creator>Marks JR, J.G.</creator><creator>Billingsley, E.M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200003</creationdate><title>Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus</title><author>Williams, J.V. ; Marks JR, J.G. ; Billingsley, E.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4875-2d698a24f60929ff43a7538bf8266c48dff4803fb9789479b219ad1b941032123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bullous diseases of the skin</topic><topic>Chemotherapy, Adjuvant</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Medical sciences</topic><topic>Mouth Mucosa - pathology</topic><topic>mycophenolate mofetil</topic><topic>Mycophenolic Acid - analogs & derivatives</topic><topic>Mycophenolic Acid - therapeutic use</topic><topic>paraneoplastic pemphigus</topic><topic>Paraneoplastic Syndromes - diagnosis</topic><topic>Paraneoplastic Syndromes - drug therapy</topic><topic>Paraneoplastic Syndromes - pathology</topic><topic>Pemphigus - diagnosis</topic><topic>Pemphigus - drug therapy</topic><topic>Pemphigus - pathology</topic><topic>Precipitin Tests</topic><topic>Prodrugs - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, J.V.</creatorcontrib><creatorcontrib>Marks JR, J.G.</creatorcontrib><creatorcontrib>Billingsley, E.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, J.V.</au><au>Marks JR, J.G.</au><au>Billingsley, E.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2000-03</date><risdate>2000</risdate><volume>142</volume><issue>3</issue><spage>506</spage><epage>508</epage><pages>506-508</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with circulating antibodies that bind the cell surface of the epidermis and other non‐stratifying epithelia, and immunoprecipitate a complex of four or five proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa). 1,2 Combinations of immunosuppressive agents are usually required to obtain even partial control of the skin lesions.
3 Mucous membrane lesions are refractory to treatment. We describe a patient with PNP whose skin and oral lesions are quiescent following treatment with oral mycophenolate mofetil.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>10735959</pmid><doi>10.1046/j.1365-2133.2000.03365.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2000-03, Vol.142 (3), p.506-508 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Biological and medical sciences Bullous diseases of the skin Chemotherapy, Adjuvant Dermatology Female Humans Immunosuppressive Agents - therapeutic use Medical sciences Mouth Mucosa - pathology mycophenolate mofetil Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - therapeutic use paraneoplastic pemphigus Paraneoplastic Syndromes - diagnosis Paraneoplastic Syndromes - drug therapy Paraneoplastic Syndromes - pathology Pemphigus - diagnosis Pemphigus - drug therapy Pemphigus - pathology Precipitin Tests Prodrugs - therapeutic use Treatment Outcome |
| title | Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus |
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