An NMR and Molecular Modeling Study of the Site-Specific Binding of Histamine by Heparin, Chemically Modified Heparin, and Heparin-Derived Oligosaccharides

The diprotonated form of histamine binds site-specifically to heparin, a highly sulfated 1→4 linked repeating copolymer comprised predominantly of 2-O-sulfo-α-l-iduronic acid (the I ring) and 2-deoxy-2-sulfamido-6-O-sulfo-α-d-glucopyranosyl (the A ring). The binding is mediated by electrostatic inte...

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