The role of cysteine and homocysteine in venous and arterial thrombotic disease
Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis, whereas few data are available on the total cysteine (tCy) levels in thrombophilic patients. We studied 82 patients with a previous myocardial infarction (MI; group 1), 68 patients with a previous deep venous thrombosis (group...
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| Veröffentlicht in: | American journal of clinical pathology 2001-07, Vol.116 (1), p.56-60 |
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| creator | MARCUCCI, Rossella BRUNELLI, Tamara GIUSTI, Betti FEDI, Sandra PEPE, Guglielmina POLI, Daniela PRISCO, Domenico ABBATE, Rosanna GENSINI, Gian Franco |
| description | Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis, whereas few data are available on the total cysteine (tCy) levels in thrombophilic patients. We studied 82 patients with a previous myocardial infarction (MI; group 1), 68 patients with a previous deep venous thrombosis (group 2), and 100 control subjects (group 3). We assayed total homocysteine (tHcy) and tCy levels by high-performance liquid chromatography with fluorimetric detection. The odds ratios (ORs) for high levels of tCy and tHcy in venous thrombosis and MI were markedly increased in group 1 (fasting tCy: OR, 3.6; 95% confidence interval [CI], 1.6-11.2; postmethionine tCy: OR, 0.97; CI, 0.3-4.0; fasting tHcy: OR, 8.3; CI, 3.9-18.6; postmethionine tHcy: OR, 12.5; CI, 6.8-27.2) and in group 2 (fasting tCy: OR, 2.9; CI, 1.1-7.8; postmethionine tCy: OR, 0.86; CI 0.2-2.6; fasting tHcy: OR, 8.0; CI 3.6-18.0; postmethionine tHcy: OR, 11.0; CI, 6.0-22.1). Our data suggest that plasma tCy levels are a risk factor for venous thrombosis and MI independently of tHcy levels and that it may be appropriate to study both variables simultaneously to thoroughly study the methionine metabolism. |
| doi_str_mv | 10.1309/7A33-8EQ4-QT98-3TPX |
| format | Article |
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We studied 82 patients with a previous myocardial infarction (MI; group 1), 68 patients with a previous deep venous thrombosis (group 2), and 100 control subjects (group 3). We assayed total homocysteine (tHcy) and tCy levels by high-performance liquid chromatography with fluorimetric detection. The odds ratios (ORs) for high levels of tCy and tHcy in venous thrombosis and MI were markedly increased in group 1 (fasting tCy: OR, 3.6; 95% confidence interval [CI], 1.6-11.2; postmethionine tCy: OR, 0.97; CI, 0.3-4.0; fasting tHcy: OR, 8.3; CI, 3.9-18.6; postmethionine tHcy: OR, 12.5; CI, 6.8-27.2) and in group 2 (fasting tCy: OR, 2.9; CI, 1.1-7.8; postmethionine tCy: OR, 0.86; CI 0.2-2.6; fasting tHcy: OR, 8.0; CI 3.6-18.0; postmethionine tHcy: OR, 11.0; CI, 6.0-22.1). Our data suggest that plasma tCy levels are a risk factor for venous thrombosis and MI independently of tHcy levels and that it may be appropriate to study both variables simultaneously to thoroughly study the methionine metabolism.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/7A33-8EQ4-QT98-3TPX</identifier><identifier>PMID: 11447752</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arteries ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Coronary heart disease ; Cysteine - blood ; Cysteine - physiology ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Fasting - blood ; Female ; Heart ; Homocysteine - blood ; Homocysteine - physiology ; Humans ; Male ; Medical sciences ; Methionine ; Middle Aged ; Myocardial Infarction - blood ; Reference Values ; Thrombosis - blood ; Thrombosis - etiology ; Venous Thrombosis - blood ; Venous Thrombosis - etiology</subject><ispartof>American journal of clinical pathology, 2001-07, Vol.116 (1), p.56-60</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-bfac28bffde8774054e170fdbe9a09bed5b06207c9c3ca5fec2b0f03eed91ca13</citedby><cites>FETCH-LOGICAL-c375t-bfac28bffde8774054e170fdbe9a09bed5b06207c9c3ca5fec2b0f03eed91ca13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1117382$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11447752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARCUCCI, Rossella</creatorcontrib><creatorcontrib>BRUNELLI, Tamara</creatorcontrib><creatorcontrib>GIUSTI, Betti</creatorcontrib><creatorcontrib>FEDI, Sandra</creatorcontrib><creatorcontrib>PEPE, Guglielmina</creatorcontrib><creatorcontrib>POLI, Daniela</creatorcontrib><creatorcontrib>PRISCO, Domenico</creatorcontrib><creatorcontrib>ABBATE, Rosanna</creatorcontrib><creatorcontrib>GENSINI, Gian Franco</creatorcontrib><title>The role of cysteine and homocysteine in venous and arterial thrombotic disease</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis, whereas few data are available on the total cysteine (tCy) levels in thrombophilic patients. We studied 82 patients with a previous myocardial infarction (MI; group 1), 68 patients with a previous deep venous thrombosis (group 2), and 100 control subjects (group 3). We assayed total homocysteine (tHcy) and tCy levels by high-performance liquid chromatography with fluorimetric detection. The odds ratios (ORs) for high levels of tCy and tHcy in venous thrombosis and MI were markedly increased in group 1 (fasting tCy: OR, 3.6; 95% confidence interval [CI], 1.6-11.2; postmethionine tCy: OR, 0.97; CI, 0.3-4.0; fasting tHcy: OR, 8.3; CI, 3.9-18.6; postmethionine tHcy: OR, 12.5; CI, 6.8-27.2) and in group 2 (fasting tCy: OR, 2.9; CI, 1.1-7.8; postmethionine tCy: OR, 0.86; CI 0.2-2.6; fasting tHcy: OR, 8.0; CI 3.6-18.0; postmethionine tHcy: OR, 11.0; CI, 6.0-22.1). Our data suggest that plasma tCy levels are a risk factor for venous thrombosis and MI independently of tHcy levels and that it may be appropriate to study both variables simultaneously to thoroughly study the methionine metabolism.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arteries</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Cysteine - blood</subject><subject>Cysteine - physiology</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Heart</subject><subject>Homocysteine - blood</subject><subject>Homocysteine - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methionine</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Reference Values</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - etiology</subject><subject>Venous Thrombosis - blood</subject><subject>Venous Thrombosis - etiology</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1LwzAUhoMobk5_gSC9EO-qJ0m7NJdjzA8YzEEF70KanrBK28ykE_bvbd1Qrw6c87wvh4eQawr3lIN8EDPO42yxTuJ1LrOY56_vJ2RMZcJjIRg7JWMAYLGkgo_IRQgfAJRlkJyTEaVJIkTKxmSVbzDyrsbI2cjsQ4dVi5Fuy2jjGve7qNroC1u3Cz8n7Tv0la6jbuNdU7iuMlFZBdQBL8mZ1XXAq-OckLfHRT5_jperp5f5bBkbLtIuLqw2LCusLTETIoE0QSrAlgVKDbLAMi1gykAYabjRqUXDCrDAEUtJjaZ8Qu4OvVvvPncYOtVUwWBd6xb7N5UAKVOaTXuQH0DjXQgerdr6qtF-ryiowaMaPKrBoxo8qsFjn7o51u-KBsu_zFFcD9weAR2Mrq3XranCP663njH-Dddbfe4</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>MARCUCCI, Rossella</creator><creator>BRUNELLI, Tamara</creator><creator>GIUSTI, Betti</creator><creator>FEDI, Sandra</creator><creator>PEPE, Guglielmina</creator><creator>POLI, Daniela</creator><creator>PRISCO, Domenico</creator><creator>ABBATE, Rosanna</creator><creator>GENSINI, Gian Franco</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>The role of cysteine and homocysteine in venous and arterial thrombotic disease</title><author>MARCUCCI, Rossella ; BRUNELLI, Tamara ; GIUSTI, Betti ; FEDI, Sandra ; PEPE, Guglielmina ; POLI, Daniela ; PRISCO, Domenico ; ABBATE, Rosanna ; GENSINI, Gian Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-bfac28bffde8774054e170fdbe9a09bed5b06207c9c3ca5fec2b0f03eed91ca13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arteries</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Cysteine - blood</topic><topic>Cysteine - physiology</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Heart</topic><topic>Homocysteine - blood</topic><topic>Homocysteine - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methionine</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Reference Values</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - etiology</topic><topic>Venous Thrombosis - blood</topic><topic>Venous Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARCUCCI, Rossella</creatorcontrib><creatorcontrib>BRUNELLI, Tamara</creatorcontrib><creatorcontrib>GIUSTI, Betti</creatorcontrib><creatorcontrib>FEDI, Sandra</creatorcontrib><creatorcontrib>PEPE, Guglielmina</creatorcontrib><creatorcontrib>POLI, Daniela</creatorcontrib><creatorcontrib>PRISCO, Domenico</creatorcontrib><creatorcontrib>ABBATE, Rosanna</creatorcontrib><creatorcontrib>GENSINI, Gian Franco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARCUCCI, Rossella</au><au>BRUNELLI, Tamara</au><au>GIUSTI, Betti</au><au>FEDI, Sandra</au><au>PEPE, Guglielmina</au><au>POLI, Daniela</au><au>PRISCO, Domenico</au><au>ABBATE, Rosanna</au><au>GENSINI, Gian Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of cysteine and homocysteine in venous and arterial thrombotic disease</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>116</volume><issue>1</issue><spage>56</spage><epage>60</epage><pages>56-60</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis, whereas few data are available on the total cysteine (tCy) levels in thrombophilic patients. We studied 82 patients with a previous myocardial infarction (MI; group 1), 68 patients with a previous deep venous thrombosis (group 2), and 100 control subjects (group 3). We assayed total homocysteine (tHcy) and tCy levels by high-performance liquid chromatography with fluorimetric detection. The odds ratios (ORs) for high levels of tCy and tHcy in venous thrombosis and MI were markedly increased in group 1 (fasting tCy: OR, 3.6; 95% confidence interval [CI], 1.6-11.2; postmethionine tCy: OR, 0.97; CI, 0.3-4.0; fasting tHcy: OR, 8.3; CI, 3.9-18.6; postmethionine tHcy: OR, 12.5; CI, 6.8-27.2) and in group 2 (fasting tCy: OR, 2.9; CI, 1.1-7.8; postmethionine tCy: OR, 0.86; CI 0.2-2.6; fasting tHcy: OR, 8.0; CI 3.6-18.0; postmethionine tHcy: OR, 11.0; CI, 6.0-22.1). Our data suggest that plasma tCy levels are a risk factor for venous thrombosis and MI independently of tHcy levels and that it may be appropriate to study both variables simultaneously to thoroughly study the methionine metabolism.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>11447752</pmid><doi>10.1309/7A33-8EQ4-QT98-3TPX</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Arteries Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary heart disease Cysteine - blood Cysteine - physiology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fasting - blood Female Heart Homocysteine - blood Homocysteine - physiology Humans Male Medical sciences Methionine Middle Aged Myocardial Infarction - blood Reference Values Thrombosis - blood Thrombosis - etiology Venous Thrombosis - blood Venous Thrombosis - etiology |
| title | The role of cysteine and homocysteine in venous and arterial thrombotic disease |
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