The mRNA level of the potassium-chloride cotransporter KCC2 covaries with seizure susceptibility in inferior colliculus of the post-ischemic audiogenic seizure-prone rat

Cardiac arrest and resuscitation were used to induce brain damage and susceptibility to sound-triggered seizures in Sprague–Dawley rats. Glucose preloading was used to vary seizure susceptibility. Because loop diuretics can block these seizures, we investigated changes in KCC2, a potassium-chloride...

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Veröffentlicht in:	Neuroscience letters 2001-07, Vol.308 (1), p.29-32
Hauptverfasser:	Reid, K.H., Li, G.-Y., Payne, R.S., Schurr, A., Cooper, N.G.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - genetics Brain Ischemia - complications Brain Ischemia - metabolism Brain Ischemia - physiopathology Carrier Proteins - genetics Chloride Channels - genetics Chloride Channels - metabolism Disease Models, Animal Disease Susceptibility - metabolism Diuretics - pharmacology Epilepsy - genetics Epilepsy - metabolism Epilepsy - physiopathology Epilepsy, Reflex - genetics Epilepsy, Reflex - metabolism Epilepsy, Reflex - physiopathology Genetic Predisposition to Disease Glucose - pharmacology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Heart Arrest, Induced Inferior Colliculi - metabolism Inferior Colliculi - physiopathology Inferior colliculus K Cl- Cotransporters Medical sciences Nervous system (semeiology, syndromes) Neurology Neurons - metabolism Polymerase Chain Reaction Post-ischemic audiogenic seizure Potassium-chloride cotransporter KCC2 Rat Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Seizure susceptibility Symporters Up-Regulation - genetics
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