Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease
Epidemiological studies suggest that tea consumption decreases cardiovascular risk, but the mechanisms of benefit remain undefined. Endothelial dysfunction has been associated with coronary artery disease and increased oxidative stress. Some antioxidants have been shown to reverse endothelial dysfun...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2001-07, Vol.104 (2), p.151-156 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | DUFFY, Stephen J KEANEY, John F HOLBROOK, Monika GOKCE, Noyan SWERDLOFF, Peter L FREI, Balz VITA, Joseph A |
| description | Epidemiological studies suggest that tea consumption decreases cardiovascular risk, but the mechanisms of benefit remain undefined. Endothelial dysfunction has been associated with coronary artery disease and increased oxidative stress. Some antioxidants have been shown to reverse endothelial dysfunction, and tea contains antioxidant flavonoids. Methods and Results-- To test the hypothesis that tea consumption will reverse endothelial dysfunction, we randomized 66 patients with proven coronary artery disease to consume black tea and water in a crossover design. Short-term effects were examined 2 hours after consumption of 450 mL tea or water. Long-term effects were examined after consumption of 900 mL tea or water daily for 4 weeks. Vasomotor function of the brachial artery was examined at baseline and after each intervention with vascular ultrasound. Fifty patients completed the protocol and had technically suitable ultrasound measurements. Both short- and long-term tea consumption improved endothelium- dependent flow-mediated dilation of the brachial artery, whereas consumption of water had no effect (P |
| doi_str_mv | 10.1161/01.CIR.104.2.151 |
| format | Article |
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Short- and long-term black tea consumption reverses endothelial vasomotor dysfunction in patients with coronary artery disease. This finding may partly explain the association between tea intake and decreased cardiovascular disease events.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.104.2.151</identifier><identifier>PMID: 11447078</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Administration, Oral ; Antioxidants - metabolism ; Biological and medical sciences ; Blood Glucose - drug effects ; Brachial Artery - diagnostic imaging ; Brachial Artery - drug effects ; Brachial Artery - physiopathology ; Caffeine - administration & dosage ; Cardiology. Vascular system ; Coronary Disease - blood ; Coronary Disease - physiopathology ; Coronary heart disease ; Cross-Over Studies ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Female ; Flavonoids - blood ; Heart ; Hemodynamics - drug effects ; Humans ; Lipids - blood ; Male ; Medical sciences ; Middle Aged ; Plant Extracts - administration & dosage ; Tea - metabolism ; Ultrasonography ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology ; Vasomotor System - drug effects ; Vasomotor System - physiopathology</subject><ispartof>Circulation (New York, N.Y.), 2001-07, Vol.104 (2), p.151-156</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jul 10, 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-97b81f807bb53fabdb98152b54887519136bdf3dade54aebfa6cfef79833f0b03</citedby><cites>FETCH-LOGICAL-c434t-97b81f807bb53fabdb98152b54887519136bdf3dade54aebfa6cfef79833f0b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1050871$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11447078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DUFFY, Stephen J</creatorcontrib><creatorcontrib>KEANEY, John F</creatorcontrib><creatorcontrib>HOLBROOK, Monika</creatorcontrib><creatorcontrib>GOKCE, Noyan</creatorcontrib><creatorcontrib>SWERDLOFF, Peter L</creatorcontrib><creatorcontrib>FREI, Balz</creatorcontrib><creatorcontrib>VITA, Joseph A</creatorcontrib><title>Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Epidemiological studies suggest that tea consumption decreases cardiovascular risk, but the mechanisms of benefit remain undefined. Endothelial dysfunction has been associated with coronary artery disease and increased oxidative stress. Some antioxidants have been shown to reverse endothelial dysfunction, and tea contains antioxidant flavonoids. Methods and Results-- To test the hypothesis that tea consumption will reverse endothelial dysfunction, we randomized 66 patients with proven coronary artery disease to consume black tea and water in a crossover design. Short-term effects were examined 2 hours after consumption of 450 mL tea or water. Long-term effects were examined after consumption of 900 mL tea or water daily for 4 weeks. Vasomotor function of the brachial artery was examined at baseline and after each intervention with vascular ultrasound. Fifty patients completed the protocol and had technically suitable ultrasound measurements. Both short- and long-term tea consumption improved endothelium- dependent flow-mediated dilation of the brachial artery, whereas consumption of water had no effect (P<0.001 by repeated-measures ANOVA). Tea consumption had no effect on endothelium-independent nitroglycerin-induced dilation. An equivalent oral dose of caffeine (200 mg) had no short-term effect on flow-mediated dilation. Plasma flavonoids increased after short- and long-term tea consumption.
Short- and long-term black tea consumption reverses endothelial vasomotor dysfunction in patients with coronary artery disease. This finding may partly explain the association between tea intake and decreased cardiovascular disease events.</description><subject>Administration, Oral</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Brachial Artery - drug effects</subject><subject>Brachial Artery - physiopathology</subject><subject>Caffeine - administration & dosage</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Cross-Over Studies</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Flavonoids - blood</subject><subject>Heart</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Plant Extracts - administration & dosage</subject><subject>Tea - metabolism</subject><subject>Ultrasonography</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasomotor System - drug effects</subject><subject>Vasomotor System - physiopathology</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU2LFDEQhoMo7rh69yRBxFu3qU7S6RxlWHVhQfDjHJLuitNrdzImaWX-vVl3QPEUCp73IVUvIc-BtQA9vGHQ7q8_tcBE27Ug4QHZgexEIyTXD8mOMaYbxbvugjzJ-baOPVfyMbkAEEIxNexI-XyIqTTUhokuMXxrCqaVusWO32lBS8cY8rYeyxwDTfgTU8ZMMUyxHHCZ7UKnU_ZbGP8Ac6BHW2YMJdNfcznUdIrBphO1qXpPdJoz2oxPySNvl4zPzu8l-fru6sv-Q3Pz8f31_u1NMwouSqOVG8APTDknubducnqo6zkphkFJ0MB7N3k-2QmlsOi87UePXumBc88c45fk9b33mOKPDXMx65xHXBYbMG7ZKKa1UB1U8OV_4G3cUqh_Mx10fS91f2dj99CYYs4JvTmmea3bGWDmrg7DwNQ66ihMZ2odNfLi7N3citPfwPn-FXh1Bmwe7eKTDeOc_xFLNijgvwHdUZSk</recordid><startdate>20010710</startdate><enddate>20010710</enddate><creator>DUFFY, Stephen J</creator><creator>KEANEY, John F</creator><creator>HOLBROOK, Monika</creator><creator>GOKCE, Noyan</creator><creator>SWERDLOFF, Peter L</creator><creator>FREI, Balz</creator><creator>VITA, Joseph A</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20010710</creationdate><title>Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease</title><author>DUFFY, Stephen J ; KEANEY, John F ; HOLBROOK, Monika ; GOKCE, Noyan ; SWERDLOFF, Peter L ; FREI, Balz ; VITA, Joseph A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-97b81f807bb53fabdb98152b54887519136bdf3dade54aebfa6cfef79833f0b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Antioxidants - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Brachial Artery - diagnostic imaging</topic><topic>Brachial Artery - drug effects</topic><topic>Brachial Artery - physiopathology</topic><topic>Caffeine - administration & dosage</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Cross-Over Studies</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Flavonoids - blood</topic><topic>Heart</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Plant Extracts - administration & dosage</topic><topic>Tea - metabolism</topic><topic>Ultrasonography</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasomotor System - drug effects</topic><topic>Vasomotor System - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DUFFY, Stephen J</creatorcontrib><creatorcontrib>KEANEY, John F</creatorcontrib><creatorcontrib>HOLBROOK, Monika</creatorcontrib><creatorcontrib>GOKCE, Noyan</creatorcontrib><creatorcontrib>SWERDLOFF, Peter L</creatorcontrib><creatorcontrib>FREI, Balz</creatorcontrib><creatorcontrib>VITA, Joseph A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUFFY, Stephen J</au><au>KEANEY, John F</au><au>HOLBROOK, Monika</au><au>GOKCE, Noyan</au><au>SWERDLOFF, Peter L</au><au>FREI, Balz</au><au>VITA, Joseph A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2001-07-10</date><risdate>2001</risdate><volume>104</volume><issue>2</issue><spage>151</spage><epage>156</epage><pages>151-156</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Epidemiological studies suggest that tea consumption decreases cardiovascular risk, but the mechanisms of benefit remain undefined. Endothelial dysfunction has been associated with coronary artery disease and increased oxidative stress. Some antioxidants have been shown to reverse endothelial dysfunction, and tea contains antioxidant flavonoids. Methods and Results-- To test the hypothesis that tea consumption will reverse endothelial dysfunction, we randomized 66 patients with proven coronary artery disease to consume black tea and water in a crossover design. Short-term effects were examined 2 hours after consumption of 450 mL tea or water. Long-term effects were examined after consumption of 900 mL tea or water daily for 4 weeks. Vasomotor function of the brachial artery was examined at baseline and after each intervention with vascular ultrasound. Fifty patients completed the protocol and had technically suitable ultrasound measurements. Both short- and long-term tea consumption improved endothelium- dependent flow-mediated dilation of the brachial artery, whereas consumption of water had no effect (P<0.001 by repeated-measures ANOVA). Tea consumption had no effect on endothelium-independent nitroglycerin-induced dilation. An equivalent oral dose of caffeine (200 mg) had no short-term effect on flow-mediated dilation. Plasma flavonoids increased after short- and long-term tea consumption.
Short- and long-term black tea consumption reverses endothelial vasomotor dysfunction in patients with coronary artery disease. This finding may partly explain the association between tea intake and decreased cardiovascular disease events.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11447078</pmid><doi>10.1161/01.CIR.104.2.151</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 2001-07, Vol.104 (2), p.151-156 |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; American Heart Association; Journals@Ovid Complete |
| subjects | Administration, Oral Antioxidants - metabolism Biological and medical sciences Blood Glucose - drug effects Brachial Artery - diagnostic imaging Brachial Artery - drug effects Brachial Artery - physiopathology Caffeine - administration & dosage Cardiology. Vascular system Coronary Disease - blood Coronary Disease - physiopathology Coronary heart disease Cross-Over Studies Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female Flavonoids - blood Heart Hemodynamics - drug effects Humans Lipids - blood Male Medical sciences Middle Aged Plant Extracts - administration & dosage Tea - metabolism Ultrasonography Vasodilation - drug effects Vasodilator Agents - pharmacology Vasomotor System - drug effects Vasomotor System - physiopathology |
| title | Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease |
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