Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells

The objective of this study was to determine if prenylchalcones (open C-ring flavonoids) and prenylflavanones from hops and beer are inducers of quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cell line. All the prenylchalcones and prenylflavanones tested were found to induce QR but not CYP1...

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Veröffentlicht in:	Cancer letters 2000-02, Vol.149 (1), p.21-29
Hauptverfasser:	Miranda, C.L, Aponso, G.L.M, Stevens, J.F, Deinzer, M.L, Buhler, D.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chalcone - pharmacology Chalcones CYP1A1 Enzyme Induction - drug effects Flavanones Flavonoids - pharmacology Foods and miscellaneous Hepa 1c1c7 Hops Liver Neoplasms, Experimental - enzymology Medical sciences Mice NAD(P)H Dehydrogenase (Quinone) - metabolism Prenylflavonoids Quinone reductase Tumor Cells, Cultured Tumors
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