Choline plus cytidine stimulate phospholipid production, and the expression and secretion of amyloid precursor protein in rat PC12 cells

The amyloid precursor protein (APP) is a transmembrane protein anchored in the membrane lipid bilayer. Choline and cytidine are major precursors of cell membranes, and are regulatory elements in membrane biosynthesis. We examined the levels of cellular APP holoprotein and secreted APPs when rat PC12...

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Veröffentlicht in:	Neuroscience letters 2000-03, Vol.283 (1), p.25-28
Hauptverfasser:	Wang, Chuan-Song, Lee, Robert K.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Protein Precursor - drug effects Amyloid beta-Protein Precursor - metabolism Animals Biological and medical sciences Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - pathology Choline - metabolism Choline - pharmacology Citicoline cytidine Cytidine - metabolism Cytidine - pharmacology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Lipids Lipotropic Agents - metabolism Lipotropic Agents - pharmacology Medical sciences Membrane structure Neurite outgrowth Neurology Neurotrophic PC12 Cells - drug effects PC12 Cells - metabolism Phospholipids - biosynthesis Pregnancy Rats
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