Monoclonal antibodies to the myeloid stem cells : therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate

There are several competing models of stem cell involvement in acute myeloid leukemia (AML). At issue is whether the disease origin is in the pluripotent stem cell or whether it arises later in a more mature progenitor cell. The observation that the CD33 antigen is present on AML cells, and on norma...

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Veröffentlicht in:	Leukemia 2000-03, Vol.14 (3), p.474-475
1. Verfasser:	BERNSTEIN, I. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute myeloid leukemia Aminoglycosides Animals Anti-Bacterial Agents - immunology Anti-Bacterial Agents - therapeutic use Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antibody Specificity Antigens Antigens, CD - immunology Antigens, Differentiation, Myelomonocytic - immunology Antineoplastic agents Biological and medical sciences Calicheamicin CD33 antigen Cell culture Cell Lineage Chemotherapy Conjugates Hematopoiesis Hematopoietic Stem Cells - immunology Hemopoiesis HL-60 Cells - drug effects HL-60 Cells - immunology HL-60 Cells - transplantation Humans Immunoconjugates - therapeutic use Immunotherapy Leukemia Leukemia, Myeloid - immunology Leukemia, Myeloid - pathology Leukemia, Myeloid - therapy Medical sciences Mice Monoclonal antibodies Neoplasm Transplantation Neoplastic Stem Cells - immunology Pharmacology. Drug treatments Pluripotency Progenitor cells Sialic Acid Binding Ig-like Lectin 3 Stem cells Transplantation, Heterologous Treatment Outcome
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