New Advances in the Transport of Doxorubicin through the Blood-Brain Barrier by a Peptide Vector-Mediated Strategy

Many therapeutic drugs are excluded from entering the brain, due to their lack of transport through the blood-brain barrier (BBB). To overcome this problem, we have developed a novel method in which short, naturally derived peptides (16–18 amino acids) cross the cellular membranes of the BBB with...

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Veröffentlicht in:	Molecular pharmacology 2000-04, Vol.57 (4), p.679-686
Hauptverfasser:	Rousselle, C, Clair, P, Lefauconnier, J M, Kaczorek, M, Scherrmann, J M, Temsamani, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacokinetics Biological Transport Blood-Brain Barrier Doxorubicin - analogs & derivatives Doxorubicin - metabolism Doxorubicin - pharmacokinetics Drug Carriers Female Male Mice Mice, Nude Peptides - metabolism Rats Rats, Sprague-Dawley
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