Fragmentation of human ceruloplasmin induced by hydrogen peroxide

We investigated the fragmentation of human ceruloplasmin induced by H 2O 2 to study its oxidative damage. When ceruloplasmin was incubated with H 2O 2, the frequency of the protein fragmentation increased in a proportion to the concentration of H 2O 2. It also increased in a time-dependent manner an...

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Veröffentlicht in:	Biochimie 2000-02, Vol.82 (2), p.175-180
Hauptverfasser:	Choi, Soo Young, Kwon, Hyeok Yil, Kwon, Oh Bin, Eum, Won Sik, Kang, Jung Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	ceruloplasmin Ceruloplasmin - chemistry Ceruloplasmin - metabolism Copper - metabolism copper ion Cytochrome c Group - metabolism fragmentation Humans hydrogen peroxide Hydrogen Peroxide - metabolism Hydroxyl Radical Oxidation-Reduction
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