Targeted insertion of Cre recombinase into the TNAP gene: Excision in primordial germ cells

Cell type-specific genomic alterations afforded by the Cre/loxP system are a powerful approach to study the function of genes in particular cell lineages and for which generalized null mutations result in early lethal phenotypes (Lobe and Nagy, 1998). Here we report the creation of a primarily PGC (...

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Veröffentlicht in:	Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2000-02, Vol.26 (2), p.116-117
Hauptverfasser:	Lomelí, Hilda, Ramos-Mejía, Verónica, Gertsenstein, Marina, Lobe, Corrinne G., Nagy, Andras
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Animals Female Gene Targeting Genes, Reporter Germ Cells - metabolism Integrases - genetics Male Mice Mice, Transgenic TNAP gene Viral Proteins
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