Prestin topology: localization of protein epitopes in relation to the plasma membrane

Computer modeling of the outer hair cell (OHC) motor protein prestin produces ambiguous results regarding transmembrane regions and localization of its termini. To determine the location of prestin's N- and C-termini, we created prestin constructs with synthetic epitopes located immediately ups...

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Veröffentlicht in:	Neuroreport 2001-07, Vol.12 (9), p.1929-1935
Hauptverfasser:	Zheng, Jing, Long, Kevin B, Shen, Weixing, Madison, Laird D, Dallos, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Specificity - genetics Biological and medical sciences Cell Membrane - chemistry Cell Membrane - ultrastructure Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Cell membranes. Ionic channels. Membrane pores Cell structures and functions DNA, Complementary - genetics Epitopes - chemistry Epitopes - genetics Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gerbillinae Green Fluorescent Proteins Hair Cells, Auditory, Outer - chemistry Hair Cells, Auditory, Outer - ultrastructure Hearing - physiology Indicators and Reagents - analysis Luminescent Proteins - analysis Membrane Potentials - drug effects Membrane Potentials - physiology Models, Biological Molecular and cellular biology prestin Protein Structure, Tertiary - physiology Proteins - chemistry Rabbits Signal Transduction - physiology Transfection
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