Structural analysis of TCRalpha and beta chains from human T-Cell clones specific for small nuclear ribonucleoprotein polypeptides Sm-D, Sm-B and U1-70 kDa: TCR complementarity determining region 3 usage appears highly conserved

Systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) are systemic autoimmune diseases that are characterized by the presence of autoantibodies reactive with U small nuclear RNP (snRNP) autoantigens. Both B and T cells are important in the pathogenesis of the disease, and T-...

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Veröffentlicht in:	Scandinavian journal of immunology 2001-07, Vol.54 (1-2), p.204-210
Hauptverfasser:	Talken, B L, Bailey, C W, Reardon, S L, Caldwell, C W, Hoffman, R W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Autoantigens - genetics Autoantigens - immunology Base Sequence Clone Cells Complementarity Determining Regions - genetics Complementarity Determining Regions - immunology DNA, Complementary Humans Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Ribonucleoprotein, U1 Small Nuclear - genetics Ribonucleoprotein, U1 Small Nuclear - immunology Ribonucleoproteins, Small Nuclear - genetics Ribonucleoproteins, Small Nuclear - immunology snRNP Core Proteins T-Lymphocytes - immunology
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