Interleukin-1 Stimulates Human Uterine Prostaglandin Production Through Induction of Cyclooxygenase-2 Expression

PROBLEM: Uterine infection occurs in as much as 20% of preterm labor and results in increased decidual cytokines. The objective of this study was to examine the effect of interleukin‐1 (IL‐1) and the cyclooxygenase‐2 (COX‐2) inhibitor, NS‐398, on myometrial prostaglandin (PG) production and COX‐2 ex...

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Veröffentlicht in:	American journal of reproductive immunology (1989) 2000-03, Vol.43 (3), p.152-159
Hauptverfasser:	RAUK, PHILLIP N., CHIAO, JYE-PING
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells, Cultured Cyclooxygenase 2 Dinoprost - biosynthesis Dinoprostone - biosynthesis Enzyme Induction - immunology Epoprostenol - biosynthesis Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans interleukin-1 Interleukin-1 - physiology Isoenzymes - biosynthesis Isoenzymes - genetics Mammalian female genital system Membrane Proteins myometrium Myometrium - cytology Myometrium - enzymology Myometrium - immunology Pregnancy Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics prostaglandins Prostaglandins - biosynthesis RNA, Messenger - biosynthesis Vertebrates: reproduction
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