Expression of constitutively active Rab5 uncouples maturation of the Salmonella‐containing vacuole from intracellular replication

The enteric bacterial pathogen Salmonella typhimurium enters and proliferates within both phagocytic and non‐phagocytic host cells. Upon entry, the bacteria reside in membrane‐bound vacuoles (SCVs) that mature with time, as evidenced by the sequential loss of early endosomal markers, followed by the...

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