Protein Transduction Domain of HIV-1 Tat Protein Promotes Efficient Delivery of DNA into Mammalian Cells

The plasma membrane of mammalian cells is one of the tight barriers against gene transfer by synthetic delivery systems. Various agents have been used to facilitate gene transfer by destabilizing the endosomal membrane under acidic conditions, but their utility is limited, especially for gene transf...

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Veröffentlicht in:	The Journal of biological chemistry 2001-07, Vol.276 (28), p.26204-26210
Hauptverfasser:	Eguchi, Akiko, Akuta, Teruo, Okuyama, Hajime, Senda, Takao, Yokoi, Haruhiko, Inokuchi, Hachiro, Fujita, Shigeo, Hayakawa, Takao, Takeda, Katsuo, Hasegawa, Mamoru, Nakanishi, Mahito
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals DNA - genetics Gene Products, tat - genetics Gene Transfer, Horizontal Genetic Vectors HIV-1 - genetics Human immunodeficiency virus 1 Humans Molecular Sequence Data tat Gene Products, Human Immunodeficiency Virus
Online-Zugang:	Volltext
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