IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection
Toxoplasma gondii is an opportunistic intracellular parasite which induces a highly strong type 1 cytokine response. The present study focuses on defining the factors influencing the outcome of infection with tachyzoites of the type I, highly lethal RH strain, relative to the type II, low virulence...
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| Veröffentlicht in: | The Journal of immunology (1950) 2001-07, Vol.167 (2), p.902-909 |
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| container_title | The Journal of immunology (1950) |
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| creator | Gavrilescu, L C Denkers, E Y |
| description | Toxoplasma gondii is an opportunistic intracellular parasite which induces a highly strong type 1 cytokine response. The present study focuses on defining the factors influencing the outcome of infection with tachyzoites of the type I, highly lethal RH strain, relative to the type II, low virulence strain ME49. Infection with the RH strain led to widespread parasite dissemination and rapid death of mice; in contrast, mice survived low virulence strain ME49 infection, and tachyzoite dissemination was much less extensive. Furthermore, massive apoptosis and disintegration of the splenic architecture was characteristic of RH, but not ME49, infection. In addition, hyperinduction of IFN-gamma and lack of NO production were found during RH, in contrast to ME49 infection. These data demonstrate that Toxoplasma strain characteristics exert a profound effect on the host immune response and that the latter itself is a crucial determinant in parasite virulence. |
| doi_str_mv | 10.4049/jimmunol.167.2.902 |
| format | Article |
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The present study focuses on defining the factors influencing the outcome of infection with tachyzoites of the type I, highly lethal RH strain, relative to the type II, low virulence strain ME49. Infection with the RH strain led to widespread parasite dissemination and rapid death of mice; in contrast, mice survived low virulence strain ME49 infection, and tachyzoite dissemination was much less extensive. Furthermore, massive apoptosis and disintegration of the splenic architecture was characteristic of RH, but not ME49, infection. In addition, hyperinduction of IFN-gamma and lack of NO production were found during RH, in contrast to ME49 infection. 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| ispartof | The Journal of immunology (1950), 2001-07, Vol.167 (2), p.902-909 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acute Disease Animals Apoptosis - immunology Cells, Cultured Cytokines - biosynthesis Female Interferon-gamma - biosynthesis Lymphocyte Count Mice Mice, Inbred C57BL Spleen - immunology Spleen - metabolism Spleen - pathology Survival Analysis T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology Toxoplasma - growth & development Toxoplasma - immunology Toxoplasma - pathogenicity Toxoplasma gondii Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - mortality Toxoplasmosis, Animal - parasitology Toxoplasmosis, Animal - pathology Virulence |
| title | IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection |
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