Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism
To measure oxidative stress, endothelial dysfunction and insulin resistance in Indian Mauritians at different stages of development of Type II (non-insulin-dependent) diabetes mellitus. Plasma total 8-epi-PGF2alpha, an indicator of oxidative stress, was determined in age-matched subjects with normal...
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| Veröffentlicht in: | Diabetologia 2001-06, Vol.44 (6), p.706-712 |
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| creator | GOPAUL, N. K MANRAJ, M. D HEBE, A LEE KWAI YAN, S JOHNSTON, A CARRIER, M. J ÄNGGARD, E. E |
| description | To measure oxidative stress, endothelial dysfunction and insulin resistance in Indian Mauritians at different stages of development of Type II (non-insulin-dependent) diabetes mellitus.
Plasma total 8-epi-PGF2alpha, an indicator of oxidative stress, was determined in age-matched subjects with normal glucose metabolism (n = 39), impaired glucose tolerance (n = 14), newly diagnosed diabetes (n = 8) and established diabetes (n = 14). Plasma glucose and insulin were measured at baseline and 2 h following an oral glucose tolerance test. Endothelial function was assessed by non-invasive digital pulse wave photoplethysmography.
Plasma 8-epi-PGF2alpha increased in subjects with impaired glucose tolerance (p < 0.05) compared with control subjects, and was even higher in newly diagnosed diabetic patients (p < 0.01) and established (p < 0.01) diabetic patients. A tendency towards reduced endothelial function in subjects with impaired glucose tolerance became significant in patients with newly diagnosed and established diabetes (p < 0.01), and was correlated with 8-epi-PGF2alpha (r = 0.36, p < 0.01). Insulin resistance (homeostasis model assessment) did not change in subjects with impaired glucose tolerance compared with control subjects, but increased in newly diagnosed (p < 0.01) and established (p < 0.001) diabetic subjects. The 8-epi-PGF2alpha was correlated with fasting glucose (r = 0.50, p < 0.001), triglycerides (r = 0.40, p < 0.001) and insulin resistance (r = 0.35, p < 0.001).
Oxidant stress is an early event in the evolution of Type II diabetes and could precede the development of endothelial dysfunction and insulin resistance. |
| doi_str_mv | 10.1007/s001250051679 |
| format | Article |
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Plasma total 8-epi-PGF2alpha, an indicator of oxidative stress, was determined in age-matched subjects with normal glucose metabolism (n = 39), impaired glucose tolerance (n = 14), newly diagnosed diabetes (n = 8) and established diabetes (n = 14). Plasma glucose and insulin were measured at baseline and 2 h following an oral glucose tolerance test. Endothelial function was assessed by non-invasive digital pulse wave photoplethysmography.
Plasma 8-epi-PGF2alpha increased in subjects with impaired glucose tolerance (p < 0.05) compared with control subjects, and was even higher in newly diagnosed diabetic patients (p < 0.01) and established (p < 0.01) diabetic patients. A tendency towards reduced endothelial function in subjects with impaired glucose tolerance became significant in patients with newly diagnosed and established diabetes (p < 0.01), and was correlated with 8-epi-PGF2alpha (r = 0.36, p < 0.01). Insulin resistance (homeostasis model assessment) did not change in subjects with impaired glucose tolerance compared with control subjects, but increased in newly diagnosed (p < 0.01) and established (p < 0.001) diabetic subjects. The 8-epi-PGF2alpha was correlated with fasting glucose (r = 0.50, p < 0.001), triglycerides (r = 0.40, p < 0.001) and insulin resistance (r = 0.35, p < 0.001).
Oxidant stress is an early event in the evolution of Type II diabetes and could precede the development of endothelial dysfunction and insulin resistance.]]></description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s001250051679</identifier><identifier>PMID: 11440363</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Anticoagulants ; Antioxidants ; Biological and medical sciences ; Blood Glucose - analysis ; Blood pressure ; Dentistry ; Diabetes ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Dinoprost - analogs & derivatives ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelium ; Endothelium, Vascular - physiopathology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; F2-Isoprostanes - blood ; Fasting - blood ; Female ; Free radicals ; Glucose ; Glucose - metabolism ; Glucose Intolerance ; Humans ; Hypertension ; India - ethnology ; Insulin Resistance ; Male ; Mauritius ; Medical research ; Medical sciences ; Metabolism ; Middle Aged ; Oxidative Stress ; Plasma ; Reference Values ; Triglycerides ; Triglycerides - blood</subject><ispartof>Diabetologia, 2001-06, Vol.44 (6), p.706-712</ispartof><rights>2001 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-dad0bd42e76328cf05bf67ae8a78d0cef4da30d810262e1293a15010610802543</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1079845$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11440363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOPAUL, N. K</creatorcontrib><creatorcontrib>MANRAJ, M. D</creatorcontrib><creatorcontrib>HEBE, A</creatorcontrib><creatorcontrib>LEE KWAI YAN, S</creatorcontrib><creatorcontrib>JOHNSTON, A</creatorcontrib><creatorcontrib>CARRIER, M. J</creatorcontrib><creatorcontrib>ÄNGGARD, E. E</creatorcontrib><title>Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description><![CDATA[To measure oxidative stress, endothelial dysfunction and insulin resistance in Indian Mauritians at different stages of development of Type II (non-insulin-dependent) diabetes mellitus.
Plasma total 8-epi-PGF2alpha, an indicator of oxidative stress, was determined in age-matched subjects with normal glucose metabolism (n = 39), impaired glucose tolerance (n = 14), newly diagnosed diabetes (n = 8) and established diabetes (n = 14). Plasma glucose and insulin were measured at baseline and 2 h following an oral glucose tolerance test. Endothelial function was assessed by non-invasive digital pulse wave photoplethysmography.
Plasma 8-epi-PGF2alpha increased in subjects with impaired glucose tolerance (p < 0.05) compared with control subjects, and was even higher in newly diagnosed diabetic patients (p < 0.01) and established (p < 0.01) diabetic patients. A tendency towards reduced endothelial function in subjects with impaired glucose tolerance became significant in patients with newly diagnosed and established diabetes (p < 0.01), and was correlated with 8-epi-PGF2alpha (r = 0.36, p < 0.01). Insulin resistance (homeostasis model assessment) did not change in subjects with impaired glucose tolerance compared with control subjects, but increased in newly diagnosed (p < 0.01) and established (p < 0.001) diabetic subjects. The 8-epi-PGF2alpha was correlated with fasting glucose (r = 0.50, p < 0.001), triglycerides (r = 0.40, p < 0.001) and insulin resistance (r = 0.35, p < 0.001).
Oxidant stress is an early event in the evolution of Type II diabetes and could precede the development of endothelial dysfunction and insulin resistance.]]></description><subject>Anticoagulants</subject><subject>Antioxidants</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood pressure</subject><subject>Dentistry</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>F2-Isoprostanes - blood</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Free radicals</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Glucose Intolerance</subject><subject>Humans</subject><subject>Hypertension</subject><subject>India - ethnology</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Mauritius</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Plasma</subject><subject>Reference Values</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkctrVTEQxoMo9lpdupUg4u7UyeM87lKKj0JLNwruDrnJHJuSk1wzidp1_3FTekHtaoaZ33x8zMfYSwEnAmB8RwBC9gC9GMbtI7YRWskOtJwes83dqhPT8O2IPSO6BgDV6-EpOxJCa1CD2rDby9_emeJ_IqeSkYjbVIPj-4wWHXKMLpUrDN4E7m5oqdEWnyI30XEfqQYfeTvzVEy02Eb8LDpvIr8wNfvSOuK_fLnift0bn9Hx76HaRMhXLGaXgqf1OXuymED44lCP2dePH76cfu7OLz-dnb4_76yadOmccbBzWuI4KDnZBfrdMowGJzNODiwu2hkFbhIgB4lCbpURPQgYBEwge62O2dt73X1OPypSmVdPFkMwEVOleYTtpKGXDXz9ALxONcfmbZaieZFKjA3q7iGbE1HGZd5nv5p8MwuY76KZ_4um8a8OonW3ovtLH7JowJsDYMiasOT2UU__qI7NXq_-APbMl4w</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>GOPAUL, N. 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Target tissue resistance</topic><topic>F2-Isoprostanes - blood</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Free radicals</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>Glucose Intolerance</topic><topic>Humans</topic><topic>Hypertension</topic><topic>India - ethnology</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Mauritius</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Plasma</topic><topic>Reference Values</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOPAUL, N. K</creatorcontrib><creatorcontrib>MANRAJ, M. D</creatorcontrib><creatorcontrib>HEBE, A</creatorcontrib><creatorcontrib>LEE KWAI YAN, S</creatorcontrib><creatorcontrib>JOHNSTON, A</creatorcontrib><creatorcontrib>CARRIER, M. 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K</au><au>MANRAJ, M. D</au><au>HEBE, A</au><au>LEE KWAI YAN, S</au><au>JOHNSTON, A</au><au>CARRIER, M. J</au><au>ÄNGGARD, E. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>44</volume><issue>6</issue><spage>706</spage><epage>712</epage><pages>706-712</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract><![CDATA[To measure oxidative stress, endothelial dysfunction and insulin resistance in Indian Mauritians at different stages of development of Type II (non-insulin-dependent) diabetes mellitus.
Plasma total 8-epi-PGF2alpha, an indicator of oxidative stress, was determined in age-matched subjects with normal glucose metabolism (n = 39), impaired glucose tolerance (n = 14), newly diagnosed diabetes (n = 8) and established diabetes (n = 14). Plasma glucose and insulin were measured at baseline and 2 h following an oral glucose tolerance test. Endothelial function was assessed by non-invasive digital pulse wave photoplethysmography.
Plasma 8-epi-PGF2alpha increased in subjects with impaired glucose tolerance (p < 0.05) compared with control subjects, and was even higher in newly diagnosed diabetic patients (p < 0.01) and established (p < 0.01) diabetic patients. A tendency towards reduced endothelial function in subjects with impaired glucose tolerance became significant in patients with newly diagnosed and established diabetes (p < 0.01), and was correlated with 8-epi-PGF2alpha (r = 0.36, p < 0.01). Insulin resistance (homeostasis model assessment) did not change in subjects with impaired glucose tolerance compared with control subjects, but increased in newly diagnosed (p < 0.01) and established (p < 0.001) diabetic subjects. The 8-epi-PGF2alpha was correlated with fasting glucose (r = 0.50, p < 0.001), triglycerides (r = 0.40, p < 0.001) and insulin resistance (r = 0.35, p < 0.001).
Oxidant stress is an early event in the evolution of Type II diabetes and could precede the development of endothelial dysfunction and insulin resistance.]]></abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11440363</pmid><doi>10.1007/s001250051679</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anticoagulants Antioxidants Biological and medical sciences Blood Glucose - analysis Blood pressure Dentistry Diabetes Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Dinoprost - analogs & derivatives Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium Endothelium, Vascular - physiopathology Etiopathogenesis. Screening. Investigations. Target tissue resistance F2-Isoprostanes - blood Fasting - blood Female Free radicals Glucose Glucose - metabolism Glucose Intolerance Humans Hypertension India - ethnology Insulin Resistance Male Mauritius Medical research Medical sciences Metabolism Middle Aged Oxidative Stress Plasma Reference Values Triglycerides Triglycerides - blood |
| title | Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism |
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