Correlation of tissue and blood plasminogen activation system in breast cancer
The plasminogen activation system plays a crucial role during cancer invasion and metastasis. In the solid tumor, urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor type-1 (PAI-1) and uPA receptor (uPAR) are considered as prognostic factors. In this study, we have investigat...
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| Veröffentlicht in: | Cancer letters 2000-03, Vol.150 (2), p.137-145 |
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| container_title | Cancer letters |
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| creator | Rha, Sun Young Yang, Woo Ick Gong, Soo Jung Kim, Jin Ju Yoo, Nae Choon Roh, Jae Kyung Min, Jin Sik Lee, Kyong Sik Kim, Byung Soo Chung, Hyun Cheol |
| description | The plasminogen activation system plays a crucial role during cancer invasion and metastasis. In the solid tumor, urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor type-1 (PAI-1) and uPA receptor (uPAR) are considered as prognostic factors. In this study, we have investigated whether secretion of the uPA, PAI-1 and uPAR from the primary breast cancer tissue can be detected in the blood of the patients using the ELISA assay. We have found that the plasminogen activation system (uPA, PAI-1, uPAR) of tumor tissue is activated from the early stage of breast cancer. However, only a number of metastatic lymph nodes was a prognostic factor in multivariate analysis for relapse. The blood level of the plasminogen activation system correlated with that of tissue in an order of uPAR (
r
2=0.61;
P=0.001), uPA (
r
2=0.35;
P=0.001) and PAI-1 (
r
2=0.11;
P=0.001). We conclude that the total uPAR level of cancer tissue can be substituted by that which is detected in the blood for further clinical applications. |
| doi_str_mv | 10.1016/S0304-3835(99)00376-6 |
| format | Article |
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r
2=0.61;
P=0.001), uPA (
r
2=0.35;
P=0.001) and PAI-1 (
r
2=0.11;
P=0.001). We conclude that the total uPAR level of cancer tissue can be substituted by that which is detected in the blood for further clinical applications.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(99)00376-6</identifier><identifier>PMID: 10704735</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood ; Breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Enzyme-Linked Immunosorbent Assay ; Female ; Gynecology. Andrology. Obstetrics ; Host-tumor relations. Immunology. Biological markers ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; PAI-1 ; Plasminogen Activator Inhibitor 1 - analysis ; Receptors, Cell Surface - analysis ; Receptors, Urokinase Plasminogen Activator ; Survival Rate ; Tissue ; Tumors ; uPA ; uPAR ; Urokinase-Type Plasminogen Activator - metabolism</subject><ispartof>Cancer letters, 2000-03, Vol.150 (2), p.137-145</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-c8e6545fadd2869e8c387615f1ddc839e249ba7137b327a438fdb0ea7af83c933</citedby><cites>FETCH-LOGICAL-c390t-c8e6545fadd2869e8c387615f1ddc839e249ba7137b327a438fdb0ea7af83c933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3835(99)00376-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1341665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10704735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rha, Sun Young</creatorcontrib><creatorcontrib>Yang, Woo Ick</creatorcontrib><creatorcontrib>Gong, Soo Jung</creatorcontrib><creatorcontrib>Kim, Jin Ju</creatorcontrib><creatorcontrib>Yoo, Nae Choon</creatorcontrib><creatorcontrib>Roh, Jae Kyung</creatorcontrib><creatorcontrib>Min, Jin Sik</creatorcontrib><creatorcontrib>Lee, Kyong Sik</creatorcontrib><creatorcontrib>Kim, Byung Soo</creatorcontrib><creatorcontrib>Chung, Hyun Cheol</creatorcontrib><title>Correlation of tissue and blood plasminogen activation system in breast cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The plasminogen activation system plays a crucial role during cancer invasion and metastasis. In the solid tumor, urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor type-1 (PAI-1) and uPA receptor (uPAR) are considered as prognostic factors. In this study, we have investigated whether secretion of the uPA, PAI-1 and uPAR from the primary breast cancer tissue can be detected in the blood of the patients using the ELISA assay. We have found that the plasminogen activation system (uPA, PAI-1, uPAR) of tumor tissue is activated from the early stage of breast cancer. However, only a number of metastatic lymph nodes was a prognostic factor in multivariate analysis for relapse. The blood level of the plasminogen activation system correlated with that of tissue in an order of uPAR (
r
2=0.61;
P=0.001), uPA (
r
2=0.35;
P=0.001) and PAI-1 (
r
2=0.11;
P=0.001). We conclude that the total uPAR level of cancer tissue can be substituted by that which is detected in the blood for further clinical applications.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>PAI-1</subject><subject>Plasminogen Activator Inhibitor 1 - analysis</subject><subject>Receptors, Cell Surface - analysis</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><subject>Survival Rate</subject><subject>Tissue</subject><subject>Tumors</subject><subject>uPA</subject><subject>uPAR</subject><subject>Urokinase-Type Plasminogen Activator - metabolism</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtO3DAUgGGrApXh8gitvEAVLAL2OL6tUDVqCxKCBbC2HPukcpXEg08Gibdvhoxadqy8-c6x_RPyhbMLzri6fGCC1ZUwQp5Ze86Y0KpSn8iCG72stDVsjyz-kQNyiPiHMSZrLT-TA840q7WQC3K3yqVA58eUB5pbOibEDVA_RNp0OUe67jz2aci_YaA-jOllpviKI_Q0DbQp4HGkwQ8ByjHZb32HcLI7j8jTzx-Pq-vq9v7Xzer7bRWEZWMVDChZy9bHuDTKggnCaMVly2MMRlhY1rbxmgvdiKX2tTBtbBh47VsjghXiiHyb965Lft4Ajq5PGKDr_AB5g04zO62RZoJyhqFkxAKtW5fU-_LqOHPbkO4tpNtWcta6t5BOTXNfdxdsmh7iu6m53AROd8Bj8F1bpv8n_O9EzZXasquZwVTjJUFxGBJMqWIqEEYXc_rgJX8BdRiP_g</recordid><startdate>20000331</startdate><enddate>20000331</enddate><creator>Rha, Sun Young</creator><creator>Yang, Woo Ick</creator><creator>Gong, Soo Jung</creator><creator>Kim, Jin Ju</creator><creator>Yoo, Nae Choon</creator><creator>Roh, Jae Kyung</creator><creator>Min, Jin Sik</creator><creator>Lee, Kyong Sik</creator><creator>Kim, Byung Soo</creator><creator>Chung, Hyun Cheol</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000331</creationdate><title>Correlation of tissue and blood plasminogen activation system in breast cancer</title><author>Rha, Sun Young ; Yang, Woo Ick ; Gong, Soo Jung ; Kim, Jin Ju ; Yoo, Nae Choon ; Roh, Jae Kyung ; Min, Jin Sik ; Lee, Kyong Sik ; Kim, Byung Soo ; Chung, Hyun Cheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-c8e6545fadd2869e8c387615f1ddc839e249ba7137b327a438fdb0ea7af83c933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>PAI-1</topic><topic>Plasminogen Activator Inhibitor 1 - analysis</topic><topic>Receptors, Cell Surface - analysis</topic><topic>Receptors, Urokinase Plasminogen Activator</topic><topic>Survival Rate</topic><topic>Tissue</topic><topic>Tumors</topic><topic>uPA</topic><topic>uPAR</topic><topic>Urokinase-Type Plasminogen Activator - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rha, Sun Young</creatorcontrib><creatorcontrib>Yang, Woo Ick</creatorcontrib><creatorcontrib>Gong, Soo Jung</creatorcontrib><creatorcontrib>Kim, Jin Ju</creatorcontrib><creatorcontrib>Yoo, Nae Choon</creatorcontrib><creatorcontrib>Roh, Jae Kyung</creatorcontrib><creatorcontrib>Min, Jin Sik</creatorcontrib><creatorcontrib>Lee, Kyong Sik</creatorcontrib><creatorcontrib>Kim, Byung Soo</creatorcontrib><creatorcontrib>Chung, Hyun Cheol</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rha, Sun Young</au><au>Yang, Woo Ick</au><au>Gong, Soo Jung</au><au>Kim, Jin Ju</au><au>Yoo, Nae Choon</au><au>Roh, Jae Kyung</au><au>Min, Jin Sik</au><au>Lee, Kyong Sik</au><au>Kim, Byung Soo</au><au>Chung, Hyun Cheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of tissue and blood plasminogen activation system in breast cancer</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2000-03-31</date><risdate>2000</risdate><volume>150</volume><issue>2</issue><spage>137</spage><epage>145</epage><pages>137-145</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The plasminogen activation system plays a crucial role during cancer invasion and metastasis. In the solid tumor, urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor type-1 (PAI-1) and uPA receptor (uPAR) are considered as prognostic factors. In this study, we have investigated whether secretion of the uPA, PAI-1 and uPAR from the primary breast cancer tissue can be detected in the blood of the patients using the ELISA assay. We have found that the plasminogen activation system (uPA, PAI-1, uPAR) of tumor tissue is activated from the early stage of breast cancer. However, only a number of metastatic lymph nodes was a prognostic factor in multivariate analysis for relapse. The blood level of the plasminogen activation system correlated with that of tissue in an order of uPAR (
r
2=0.61;
P=0.001), uPA (
r
2=0.35;
P=0.001) and PAI-1 (
r
2=0.11;
P=0.001). We conclude that the total uPAR level of cancer tissue can be substituted by that which is detected in the blood for further clinical applications.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10704735</pmid><doi>10.1016/S0304-3835(99)00376-6</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2000-03, Vol.150 (2), p.137-145 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70983958 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Biological and medical sciences Blood Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Enzyme-Linked Immunosorbent Assay Female Gynecology. Andrology. Obstetrics Host-tumor relations. Immunology. Biological markers Humans Mammary gland diseases Medical sciences Middle Aged PAI-1 Plasminogen Activator Inhibitor 1 - analysis Receptors, Cell Surface - analysis Receptors, Urokinase Plasminogen Activator Survival Rate Tissue Tumors uPA uPAR Urokinase-Type Plasminogen Activator - metabolism |
| title | Correlation of tissue and blood plasminogen activation system in breast cancer |
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