Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

Inhibition of neocortical β-amyloid (Aβ) accumulation may be essential in an effective therapeutic intervention for Alzheimer's disease (AD). Cu and Zn are enriched in Aβ deposits in AD, which are solubilized by Cu/Zn-selective chelators in vitro. Here we report a 49% decrease in brain Aβ depos...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2001-06, Vol.30 (3), p.665-676
Hauptverfasser:	Cherny, Robert A, Atwood, Craig S, Xilinas, Michel E, Gray, Danielle N, Jones, Walton D, McLean, Catriona A, Barnham, Kevin J, Volitakis, Irene, Fraser, Fiona W, Kim, Young-Seon, Huang, Xudong, Goldstein, Lee E, Moir, Robert D, Lim, James T, Beyreuther, Konrad, Zheng, Hui, Tanzi, Rudolph E, Masters, Colin L, Bush, Ashley I
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Animals Chelating Agents - pharmacology Clioquinol - pharmacology Copper - metabolism Female Glial Fibrillary Acidic Protein - metabolism Male Mice Mice, Inbred Strains Mice, Transgenic Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Synaptophysin - metabolism Zinc - metabolism
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