Adjuvant Effect of Antibodies against von Willebrand Factor, Fibrinogen, and Fibronectin on Staphylokinase-Induced Thrombolysis as Measured Using Mural Thrombi Formed in Rat Mesenteric Venules
The change in thrombus mass during thrombolytic therapy is thought to be the difference between its growth and its degradation induced by thrombolytic agents. Platelets play a pivotal role in arterial thrombosis and bind to each other and to exposed subendothelial matrices via adhesive proteins such...
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| Veröffentlicht in: | Thrombosis research 2000-03, Vol.97 (5), p.327-333 |
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| creator | Yamamoto, Junichiro Kawano, Makiko Hashimoto, Masaru Sasaki, Yasuto Yamashita, Tsutomu Taka, Tomomi Watanabe, Sadahiro Giddings, John C |
| description | The change in thrombus mass during thrombolytic therapy is thought to be the difference between its growth and its degradation induced by thrombolytic agents. Platelets play a pivotal role in arterial thrombosis and bind to each other and to exposed subendothelial matrices via adhesive proteins such as von Willebrand Factor, fibrinogen, and fibronectin. The aim of the present study was to assess whether administration of antibodies against these adhesive proteins, in conjunction with plasminogen activator, could enhance the degradation of platelet-rich thrombus. Mural platelet-rich thrombi were formed in rat mesenteric venules using He–Ne laser irradiation. Recombinant staphylokinase was infused continuously and polyclonal antibodies against adhesive proteins were given by bolus injection. The thrombolytic process was analysed using computer-enhanced image analysis software. Administration of each of the antibodies enhanced staphylokinase-induced thrombolysis. |
| doi_str_mv | 10.1016/S0049-3848(99)00184-X |
| format | Article |
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Platelets play a pivotal role in arterial thrombosis and bind to each other and to exposed subendothelial matrices via adhesive proteins such as von Willebrand Factor, fibrinogen, and fibronectin. The aim of the present study was to assess whether administration of antibodies against these adhesive proteins, in conjunction with plasminogen activator, could enhance the degradation of platelet-rich thrombus. Mural platelet-rich thrombi were formed in rat mesenteric venules using He–Ne laser irradiation. Recombinant staphylokinase was infused continuously and polyclonal antibodies against adhesive proteins were given by bolus injection. The thrombolytic process was analysed using computer-enhanced image analysis software. Administration of each of the antibodies enhanced staphylokinase-induced thrombolysis.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/S0049-3848(99)00184-X</identifier><identifier>PMID: 10709908</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Adhesive proteins ; Adjuvants, Immunologic - pharmacology ; Animals ; Arterial thrombosis ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood. Blood coagulation. Reticuloendothelial system ; Fibrinogen - drug effects ; Fibrinogen - immunology ; Fibrinolytic Agents - pharmacology ; Fibronectins - drug effects ; Fibronectins - immunology ; Heart Diseases - drug therapy ; Immune Sera - pharmacology ; Immunoglobulin G - pharmacology ; Male ; Medical sciences ; Mesenteric Veins ; Metalloendopeptidases - pharmacology ; Pharmacology. Drug treatments ; Plasminogen Activators - pharmacology ; Platelet-rich thrombi ; Rats ; Rats, Wistar ; Staphylokinase ; Thrombolysis ; Thrombolytic Therapy ; Thrombosis - drug therapy ; von Willebrand Factor - drug effects ; von Willebrand Factor - immunology</subject><ispartof>Thrombosis research, 2000-03, Vol.97 (5), p.327-333</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-c52f534f9713f3fc0fb5a6a757968679d2d79486be0093be5010e069ec9055773</citedby><cites>FETCH-LOGICAL-c456t-c52f534f9713f3fc0fb5a6a757968679d2d79486be0093be5010e069ec9055773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0049-3848(99)00184-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1333477$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10709908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Junichiro</creatorcontrib><creatorcontrib>Kawano, Makiko</creatorcontrib><creatorcontrib>Hashimoto, Masaru</creatorcontrib><creatorcontrib>Sasaki, Yasuto</creatorcontrib><creatorcontrib>Yamashita, Tsutomu</creatorcontrib><creatorcontrib>Taka, Tomomi</creatorcontrib><creatorcontrib>Watanabe, Sadahiro</creatorcontrib><creatorcontrib>Giddings, John C</creatorcontrib><title>Adjuvant Effect of Antibodies against von Willebrand Factor, Fibrinogen, and Fibronectin on Staphylokinase-Induced Thrombolysis as Measured Using Mural Thrombi Formed in Rat Mesenteric Venules</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>The change in thrombus mass during thrombolytic therapy is thought to be the difference between its growth and its degradation induced by thrombolytic agents. Platelets play a pivotal role in arterial thrombosis and bind to each other and to exposed subendothelial matrices via adhesive proteins such as von Willebrand Factor, fibrinogen, and fibronectin. The aim of the present study was to assess whether administration of antibodies against these adhesive proteins, in conjunction with plasminogen activator, could enhance the degradation of platelet-rich thrombus. Mural platelet-rich thrombi were formed in rat mesenteric venules using He–Ne laser irradiation. Recombinant staphylokinase was infused continuously and polyclonal antibodies against adhesive proteins were given by bolus injection. The thrombolytic process was analysed using computer-enhanced image analysis software. Administration of each of the antibodies enhanced staphylokinase-induced thrombolysis.</description><subject>Adhesive proteins</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Arterial thrombosis</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Fibrinogen - drug effects</subject><subject>Fibrinogen - immunology</subject><subject>Fibrinolytic Agents - pharmacology</subject><subject>Fibronectins - drug effects</subject><subject>Fibronectins - immunology</subject><subject>Heart Diseases - drug therapy</subject><subject>Immune Sera - pharmacology</subject><subject>Immunoglobulin G - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenteric Veins</subject><subject>Metalloendopeptidases - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasminogen Activators - pharmacology</subject><subject>Platelet-rich thrombi</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Staphylokinase</subject><subject>Thrombolysis</subject><subject>Thrombolytic Therapy</subject><subject>Thrombosis - drug therapy</subject><subject>von Willebrand Factor - drug effects</subject><subject>von Willebrand Factor - immunology</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1uFCEUgCdGY9fqI2i4MKYmHYVlGIYrs2m62qSNiW21d4RhDlsqC1tgNtm389GkuxvrXa8InO_8cL6qekvwJ4JJ-_kS40bUtGu6IyE-Yky6pr55Vk1Ix0U9bfj0eTX5hxxUr1K6KxAngr2sDgjmWAjcTao_s-FuXCuf0akxoDMKBs18tn0YLCSkFsr6lNE6ePTLOgd9VH5Ac6VziMdobvtofViAP0bb93IPvpSxHpWMy6xWtxsXfluvEtRnfhg1DOjqNoZlH9wm2dIhoQtQaYwlcJ2sX6CLMSq3hyyah7gsoVLwh8oFTeAzRKvRT_Cjg_S6emGUS_Bmfx5W1_PTq5Nv9fn3r2cns_NaN6zNtWZTw2hjBCfUUKOx6ZlqFWdctF3LxTAduGi6tgeMBe2BYYIBtwK0wIxxTg-rD7u6qxjuR0hZLm3S4JzyEMYky0I7SjAtINuBOoaUIhi5inap4kYSLB_Uya06-eBFCiG36uRNyXu3bzD25cf_Ze1cFeD9HlBJK2eKCW3TI0cpbbaDftlhULaxthBl0hZ8WbyNxYwcgn1ikr-ehbjh</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Yamamoto, Junichiro</creator><creator>Kawano, Makiko</creator><creator>Hashimoto, Masaru</creator><creator>Sasaki, Yasuto</creator><creator>Yamashita, Tsutomu</creator><creator>Taka, Tomomi</creator><creator>Watanabe, Sadahiro</creator><creator>Giddings, John C</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000301</creationdate><title>Adjuvant Effect of Antibodies against von Willebrand Factor, Fibrinogen, and Fibronectin on Staphylokinase-Induced Thrombolysis as Measured Using Mural Thrombi Formed in Rat Mesenteric Venules</title><author>Yamamoto, Junichiro ; Kawano, Makiko ; Hashimoto, Masaru ; Sasaki, Yasuto ; Yamashita, Tsutomu ; Taka, Tomomi ; Watanabe, Sadahiro ; Giddings, John C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-c52f534f9713f3fc0fb5a6a757968679d2d79486be0093be5010e069ec9055773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adhesive proteins</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Arterial thrombosis</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Fibrinogen - drug effects</topic><topic>Fibrinogen - immunology</topic><topic>Fibrinolytic Agents - pharmacology</topic><topic>Fibronectins - drug effects</topic><topic>Fibronectins - immunology</topic><topic>Heart Diseases - drug therapy</topic><topic>Immune Sera - pharmacology</topic><topic>Immunoglobulin G - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesenteric Veins</topic><topic>Metalloendopeptidases - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasminogen Activators - pharmacology</topic><topic>Platelet-rich thrombi</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Staphylokinase</topic><topic>Thrombolysis</topic><topic>Thrombolytic Therapy</topic><topic>Thrombosis - drug therapy</topic><topic>von Willebrand Factor - drug effects</topic><topic>von Willebrand Factor - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Junichiro</creatorcontrib><creatorcontrib>Kawano, Makiko</creatorcontrib><creatorcontrib>Hashimoto, Masaru</creatorcontrib><creatorcontrib>Sasaki, Yasuto</creatorcontrib><creatorcontrib>Yamashita, Tsutomu</creatorcontrib><creatorcontrib>Taka, Tomomi</creatorcontrib><creatorcontrib>Watanabe, Sadahiro</creatorcontrib><creatorcontrib>Giddings, John C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Junichiro</au><au>Kawano, Makiko</au><au>Hashimoto, Masaru</au><au>Sasaki, Yasuto</au><au>Yamashita, Tsutomu</au><au>Taka, Tomomi</au><au>Watanabe, Sadahiro</au><au>Giddings, John C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adjuvant Effect of Antibodies against von Willebrand Factor, Fibrinogen, and Fibronectin on Staphylokinase-Induced Thrombolysis as Measured Using Mural Thrombi Formed in Rat Mesenteric Venules</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>97</volume><issue>5</issue><spage>327</spage><epage>333</epage><pages>327-333</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>The change in thrombus mass during thrombolytic therapy is thought to be the difference between its growth and its degradation induced by thrombolytic agents. Platelets play a pivotal role in arterial thrombosis and bind to each other and to exposed subendothelial matrices via adhesive proteins such as von Willebrand Factor, fibrinogen, and fibronectin. The aim of the present study was to assess whether administration of antibodies against these adhesive proteins, in conjunction with plasminogen activator, could enhance the degradation of platelet-rich thrombus. Mural platelet-rich thrombi were formed in rat mesenteric venules using He–Ne laser irradiation. Recombinant staphylokinase was infused continuously and polyclonal antibodies against adhesive proteins were given by bolus injection. The thrombolytic process was analysed using computer-enhanced image analysis software. Administration of each of the antibodies enhanced staphylokinase-induced thrombolysis.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>10709908</pmid><doi>10.1016/S0049-3848(99)00184-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | Thrombosis research, 2000-03, Vol.97 (5), p.327-333 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adhesive proteins Adjuvants, Immunologic - pharmacology Animals Arterial thrombosis Biological and medical sciences Blood Pressure - drug effects Blood. Blood coagulation. Reticuloendothelial system Fibrinogen - drug effects Fibrinogen - immunology Fibrinolytic Agents - pharmacology Fibronectins - drug effects Fibronectins - immunology Heart Diseases - drug therapy Immune Sera - pharmacology Immunoglobulin G - pharmacology Male Medical sciences Mesenteric Veins Metalloendopeptidases - pharmacology Pharmacology. Drug treatments Plasminogen Activators - pharmacology Platelet-rich thrombi Rats Rats, Wistar Staphylokinase Thrombolysis Thrombolytic Therapy Thrombosis - drug therapy von Willebrand Factor - drug effects von Willebrand Factor - immunology |
| title | Adjuvant Effect of Antibodies against von Willebrand Factor, Fibrinogen, and Fibronectin on Staphylokinase-Induced Thrombolysis as Measured Using Mural Thrombi Formed in Rat Mesenteric Venules |
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