Synthesis of 2‘-Modified Oligodeoxynucleotides via On-Column Conjugation

Oligodeoxynucleotides modified at the 2‘-position of 2‘-amino-2‘-deoxyuridine or uridine were prepared in high yield and purity using phosphoramidites 2 and 3, respectively. Oligodeoxynucleotide conjugates were prepared on the solid-phase synthesis support following selective unmasking of the nucleo...

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Veröffentlicht in:	Journal of organic chemistry 2001-01, Vol.66 (2), p.363-369
Hauptverfasser:	Hwang, Jae-Taeg, Greenberg, Marc M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Base Sequence Deoxyuridine - analogs & derivatives Indicators and Reagents Molecular Conformation Nucleic Acid Conformation Oligodeoxyribonucleotides - chemical synthesis Oligodeoxyribonucleotides - chemistry Phosphoric Acids Resins, Plant Uridine
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