Local Interferon‐γ Levels during Respiratory Syncytial Virus Lower Respiratory Tract Infection Are Associated with Disease Severity
To investigate the role of cell‐mediated immunity during respiratory syncytial virus (RSV) infection, interferon (IFN)–γ and interleukin (IL)–10 levels in nasopharyngeal secretions were measured in infants with lower respiratory tract infection (LRTI) caused by RSV. A novel technique was used to mea...
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| Veröffentlicht in: | The Journal of infectious diseases 2001-08, Vol.184 (3), p.355-358 |
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| container_title | The Journal of infectious diseases |
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| creator | Bont, Louis Heijnen, Cobi J. Kavelaars, Annemieke van Aalderen, Wim M. C. Brus, Frank Draaisma, Jos M. Th. Pekelharing‐Berghuis, Martha van Diemen‐Steenvoorde, Ronnie A. A. M. Kimpen, Jan L. L. |
| description | To investigate the role of cell‐mediated immunity during respiratory syncytial virus (RSV) infection, interferon (IFN)–γ and interleukin (IL)–10 levels in nasopharyngeal secretions were measured in infants with lower respiratory tract infection (LRTI) caused by RSV. A novel technique was used to measure in vivo cytokine levels in nasopharyngeal aspirates (NPAs). Cytokine levels in the NPAs of 17 mechanically ventilated infants and 43 nonventilated hospitalized infants were compared. As expected, mechanically ventilated infants were significantly younger than nonventilated infants (7 vs. 14 weeks). IFN‐γ levels were above the limit of detection in the NPAs of 3 (18%) mechanically ventilated infants and in the NPAs of 26 (60%) nonventilated infants. IL‐10 levels in the NPAs of mechanically ventilated and nonventilated infants were comparable. It is hypothesized that maturation‐related mechanisms have a key role in the development of RSV LRTI that results in mechanical ventilation. |
| doi_str_mv | 10.1086/322035 |
| format | Article |
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C. ; Brus, Frank ; Draaisma, Jos M. Th. ; Pekelharing‐Berghuis, Martha ; van Diemen‐Steenvoorde, Ronnie A. A. M. ; Kimpen, Jan L. L. </creator><creatorcontrib>Bont, Louis ; Heijnen, Cobi J. ; Kavelaars, Annemieke ; van Aalderen, Wim M. C. ; Brus, Frank ; Draaisma, Jos M. Th. ; Pekelharing‐Berghuis, Martha ; van Diemen‐Steenvoorde, Ronnie A. A. M. ; Kimpen, Jan L. L. </creatorcontrib><description>To investigate the role of cell‐mediated immunity during respiratory syncytial virus (RSV) infection, interferon (IFN)–γ and interleukin (IL)–10 levels in nasopharyngeal secretions were measured in infants with lower respiratory tract infection (LRTI) caused by RSV. A novel technique was used to measure in vivo cytokine levels in nasopharyngeal aspirates (NPAs). Cytokine levels in the NPAs of 17 mechanically ventilated infants and 43 nonventilated hospitalized infants were compared. As expected, mechanically ventilated infants were significantly younger than nonventilated infants (7 vs. 14 weeks). IFN‐γ levels were above the limit of detection in the NPAs of 3 (18%) mechanically ventilated infants and in the NPAs of 26 (60%) nonventilated infants. IL‐10 levels in the NPAs of mechanically ventilated and nonventilated infants were comparable. It is hypothesized that maturation‐related mechanisms have a key role in the development of RSV LRTI that results in mechanical ventilation.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/322035</identifier><identifier>PMID: 11443563</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>Age Factors ; Artificial respiration ; Biological and medical sciences ; Bronchiolitis ; Concise Communications ; Cytokines ; Enzyme-Linked Immunosorbent Assay ; Female ; g-Interferon ; Human respiratory syncytial virus ; Human viral diseases ; Humans ; Infant ; Infants ; Infectious diseases ; Interferon-gamma - analysis ; Interleukin-10 - analysis ; Interleukin-4 - analysis ; Interleukin-8 - analysis ; Male ; Medical sciences ; Nasopharynx - immunology ; Nasopharynx - secretion ; Netherlands ; Predictive Value of Tests ; Respiration, Artificial ; Respiratory diseases ; respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Virus Infections - physiopathology ; Respiratory syncytial viruses ; Respiratory tract infections ; Respiratory Tract Infections - immunology ; Respiratory Tract Infections - physiopathology ; Respiratory Tract Infections - therapy ; Secretion ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral diseases of the respiratory system and ent viral diseases</subject><ispartof>The Journal of infectious diseases, 2001-08, Vol.184 (3), p.355-358</ispartof><rights>Copyright 2001 Infectious Diseases Society of America</rights><rights>2001 by the Infectious Diseases Society of America 2001</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-b9e73f90118e7f871df34eadd2aa51ee3b539237eff5d486c36095b0f294b7853</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30137301$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30137301$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14157319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11443563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bont, Louis </creatorcontrib><creatorcontrib>Heijnen, Cobi J. </creatorcontrib><creatorcontrib>Kavelaars, Annemieke </creatorcontrib><creatorcontrib>van Aalderen, Wim M. C. </creatorcontrib><creatorcontrib>Brus, Frank </creatorcontrib><creatorcontrib>Draaisma, Jos M. Th. </creatorcontrib><creatorcontrib>Pekelharing‐Berghuis, Martha </creatorcontrib><creatorcontrib>van Diemen‐Steenvoorde, Ronnie A. A. M. </creatorcontrib><creatorcontrib>Kimpen, Jan L. L. </creatorcontrib><title>Local Interferon‐γ Levels during Respiratory Syncytial Virus Lower Respiratory Tract Infection Are Associated with Disease Severity</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>To investigate the role of cell‐mediated immunity during respiratory syncytial virus (RSV) infection, interferon (IFN)–γ and interleukin (IL)–10 levels in nasopharyngeal secretions were measured in infants with lower respiratory tract infection (LRTI) caused by RSV. A novel technique was used to measure in vivo cytokine levels in nasopharyngeal aspirates (NPAs). Cytokine levels in the NPAs of 17 mechanically ventilated infants and 43 nonventilated hospitalized infants were compared. As expected, mechanically ventilated infants were significantly younger than nonventilated infants (7 vs. 14 weeks). IFN‐γ levels were above the limit of detection in the NPAs of 3 (18%) mechanically ventilated infants and in the NPAs of 26 (60%) nonventilated infants. IL‐10 levels in the NPAs of mechanically ventilated and nonventilated infants were comparable. It is hypothesized that maturation‐related mechanisms have a key role in the development of RSV LRTI that results in mechanical ventilation.</description><subject>Age Factors</subject><subject>Artificial respiration</subject><subject>Biological and medical sciences</subject><subject>Bronchiolitis</subject><subject>Concise Communications</subject><subject>Cytokines</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>g-Interferon</subject><subject>Human respiratory syncytial virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - analysis</subject><subject>Interleukin-10 - analysis</subject><subject>Interleukin-4 - analysis</subject><subject>Interleukin-8 - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasopharynx - immunology</subject><subject>Nasopharynx - secretion</subject><subject>Netherlands</subject><subject>Predictive Value of Tests</subject><subject>Respiration, Artificial</subject><subject>Respiratory diseases</subject><subject>respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Virus Infections - physiopathology</subject><subject>Respiratory syncytial viruses</subject><subject>Respiratory tract infections</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Respiratory Tract Infections - physiopathology</subject><subject>Respiratory Tract Infections - therapy</subject><subject>Secretion</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cFu1DAQBmALUdFlgTcAuQe4Bew4juPjqgVaFAlBC6q4WI4zBpdsvNgOJTdOnHmXvgcPwZOQKquuOCB8sA_zeUaaH6EHlDylpCqfsTwnjN9CC8qZyMqSsttoQUieZ7SSch_djfGCEFKwUtxB-5QWBeMlW6AftTe6wyd9gmAh-P7395-_rnANX6GLuB2C6z_itxA3Lujkw4hPx96MyU1_3rswRFz7Swh_ibOgTZo6WjDJ-R6vAuBVjN44naDFly59wkcugo6AT6c5waXxHtqzuotwf_su0bsXz88Oj7P69cuTw1WdmYIXKWskCGYlobQCYStBW8sK0G2ba80pAGs4kzkTYC1vi6o0rCSSN8TmsmhExdkSPZn7boL_MkBMau2iga7TPfghKkFklU_nv5AKOS2XkB00wccYwKpNcGsdRkWJuo5GzdFM8NG249Csod2xbRYTeLwFOk6Z2KB74-LOFZQLRuXkDmbnh82_hz2czUWcMrlRjFAmrq8lyua6iwm-3dR1-KxKwQRXx-cfVFWJV2-oPFLn7A-bx7s4</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Bont, Louis </creator><creator>Heijnen, Cobi J. </creator><creator>Kavelaars, Annemieke </creator><creator>van Aalderen, Wim M. C. </creator><creator>Brus, Frank </creator><creator>Draaisma, Jos M. Th. </creator><creator>Pekelharing‐Berghuis, Martha </creator><creator>van Diemen‐Steenvoorde, Ronnie A. A. M. </creator><creator>Kimpen, Jan L. L. </creator><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Local Interferon‐γ Levels during Respiratory Syncytial Virus Lower Respiratory Tract Infection Are Associated with Disease Severity</title><author>Bont, Louis ; Heijnen, Cobi J. ; Kavelaars, Annemieke ; van Aalderen, Wim M. C. ; Brus, Frank ; Draaisma, Jos M. Th. ; Pekelharing‐Berghuis, Martha ; van Diemen‐Steenvoorde, Ronnie A. A. M. ; Kimpen, Jan L. 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Aids</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bont, Louis </creatorcontrib><creatorcontrib>Heijnen, Cobi J. </creatorcontrib><creatorcontrib>Kavelaars, Annemieke </creatorcontrib><creatorcontrib>van Aalderen, Wim M. C. </creatorcontrib><creatorcontrib>Brus, Frank </creatorcontrib><creatorcontrib>Draaisma, Jos M. Th. </creatorcontrib><creatorcontrib>Pekelharing‐Berghuis, Martha </creatorcontrib><creatorcontrib>van Diemen‐Steenvoorde, Ronnie A. A. M. </creatorcontrib><creatorcontrib>Kimpen, Jan L. 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L. </au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local Interferon‐γ Levels during Respiratory Syncytial Virus Lower Respiratory Tract Infection Are Associated with Disease Severity</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>184</volume><issue>3</issue><spage>355</spage><epage>358</epage><pages>355-358</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To investigate the role of cell‐mediated immunity during respiratory syncytial virus (RSV) infection, interferon (IFN)–γ and interleukin (IL)–10 levels in nasopharyngeal secretions were measured in infants with lower respiratory tract infection (LRTI) caused by RSV. A novel technique was used to measure in vivo cytokine levels in nasopharyngeal aspirates (NPAs). Cytokine levels in the NPAs of 17 mechanically ventilated infants and 43 nonventilated hospitalized infants were compared. As expected, mechanically ventilated infants were significantly younger than nonventilated infants (7 vs. 14 weeks). IFN‐γ levels were above the limit of detection in the NPAs of 3 (18%) mechanically ventilated infants and in the NPAs of 26 (60%) nonventilated infants. IL‐10 levels in the NPAs of mechanically ventilated and nonventilated infants were comparable. It is hypothesized that maturation‐related mechanisms have a key role in the development of RSV LRTI that results in mechanical ventilation.</abstract><cop>Chicago, IL</cop><pub>University of Chicago Press</pub><pmid>11443563</pmid><doi>10.1086/322035</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2001-08, Vol.184 (3), p.355-358 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Age Factors Artificial respiration Biological and medical sciences Bronchiolitis Concise Communications Cytokines Enzyme-Linked Immunosorbent Assay Female g-Interferon Human respiratory syncytial virus Human viral diseases Humans Infant Infants Infectious diseases Interferon-gamma - analysis Interleukin-10 - analysis Interleukin-4 - analysis Interleukin-8 - analysis Male Medical sciences Nasopharynx - immunology Nasopharynx - secretion Netherlands Predictive Value of Tests Respiration, Artificial Respiratory diseases respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - physiopathology Respiratory syncytial viruses Respiratory tract infections Respiratory Tract Infections - immunology Respiratory Tract Infections - physiopathology Respiratory Tract Infections - therapy Secretion Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral diseases of the respiratory system and ent viral diseases |
| title | Local Interferon‐γ Levels during Respiratory Syncytial Virus Lower Respiratory Tract Infection Are Associated with Disease Severity |
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