Monocyclic l-Nucleosides with Type 1 Cytokine-Inducing Activity

A series of 1,2,4-triazole l-nucleosides were synthesized and evaluated for their ability to stimulate type 1 cytokine production by activated human T cells in direct comparison to the known active agent ribavirin. Among the compounds prepared, 1-β-l-ribofuranosyl-1,2,4-triazole-3-carboxamide (5, IC...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-03, Vol.43 (5), p.1019-1028
Hauptverfasser:	Ramasamy, Kanda S, Tam, Robert C, Bard, Josie, Averett, Devron R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemical synthesis Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Humans Immunomodulators In Vitro Techniques Interferon-gamma - metabolism Interleukin-2 - metabolism Medical sciences Nucleosides - chemical synthesis Nucleosides - chemistry Nucleosides - pharmacology Pharmacology. Drug treatments Ribavirin - chemical synthesis Ribavirin - chemistry Ribavirin - pharmacology Stereoisomerism Structure-Activity Relationship T-Lymphocytes - drug effects T-Lymphocytes - metabolism Tumor Necrosis Factor-alpha - metabolism
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