Risk Factors for Anaerobic Bloodstream Infections in Bone Marrow Transplant Recipients
The incidence of anaerobic bloodstream infections (BSI) in patients who underwent bone marrow transplantation (BMT) recently increased at our institution. A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiologi...
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Veröffentlicht in: | Clinical infectious diseases 2001-08, Vol.33 (3), p.338-343 |
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creator | Lark, Rebecca L. McNeil, Shelly A. VanderHyde, Kristi Noorani, Zehra Uberti, Joseph Chenoweth, Carol |
description | The incidence of anaerobic bloodstream infections (BSI) in patients who underwent bone marrow transplantation (BMT) recently increased at our institution. A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiological characteristics, epidemiology, and outcome of anaerobic BSI and to identify independent risk factors for infection. Anaerobic BSI occurred in 23 patients, for a rate of 4 BSIs per 100 BMT procedures, and it accounted for 17% of all BSIs that occurred during the study period. Infection occurred at a mean (± standard deviation) of 7 ± 4 days after BMT and 7 ± 5 days after the onset of neutropenia. Fusobacterium nucleatum was the most frequently isolated pathogen (in 17 patients), followed by Leptotrichia buccalis (in 4), Clostridium septicum (in 1), and Clostridium tertium (in 1). Two case patients (9%) died. Severity of mucositis was an independent predictor of anaerobic BSI (odds ratio, 4.4; P = .01). Controlling mucositis is critical for the prevention of anaerobic BSI in this patient population. |
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A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiological characteristics, epidemiology, and outcome of anaerobic BSI and to identify independent risk factors for infection. Anaerobic BSI occurred in 23 patients, for a rate of 4 BSIs per 100 BMT procedures, and it accounted for 17% of all BSIs that occurred during the study period. Infection occurred at a mean (± standard deviation) of 7 ± 4 days after BMT and 7 ± 5 days after the onset of neutropenia. Fusobacterium nucleatum was the most frequently isolated pathogen (in 17 patients), followed by Leptotrichia buccalis (in 4), Clostridium septicum (in 1), and Clostridium tertium (in 1). Two case patients (9%) died. Severity of mucositis was an independent predictor of anaerobic BSI (odds ratio, 4.4; P = .01). Controlling mucositis is critical for the prevention of anaerobic BSI in this patient population.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/322595</identifier><identifier>PMID: 11438899</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Agranulocytosis - complications ; Anaerobic bacteria ; Antimicrobials ; Bacteremia ; Bacteremia - etiology ; Bacteria, Anaerobic ; Bacterial diseases ; Bacterial sepsis ; Biological and medical sciences ; Blood ; Bone marrow ; Bone Marrow Transplantation - adverse effects ; Case-Control Studies ; Diarrhea ; Female ; Human bacterial diseases ; Humans ; Immunocompromised Host ; Infections ; Infectious diseases ; Logistic Models ; Major Articles ; Male ; Medical sciences ; Mucositis ; Mucous Membrane - immunology ; Neutropenia ; Predisposing factors ; Retrospective Studies ; Risk Factors</subject><ispartof>Clinical infectious diseases, 2001-08, Vol.33 (3), p.338-343</ispartof><rights>Copyright 2001 The Infectious Diseases Society of America</rights><rights>2001 by the Infectious Diseases Society of America 2001</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-b46f48b09fcb9fdcec57e049f12c8bbe970c088106ec19ee397d6cac6196d9f63</citedby><cites>FETCH-LOGICAL-c518t-b46f48b09fcb9fdcec57e049f12c8bbe970c088106ec19ee397d6cac6196d9f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4482739$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4482739$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,27907,27908,58000,58233</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1098824$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11438899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lark, Rebecca L.</creatorcontrib><creatorcontrib>McNeil, Shelly A.</creatorcontrib><creatorcontrib>VanderHyde, Kristi</creatorcontrib><creatorcontrib>Noorani, Zehra</creatorcontrib><creatorcontrib>Uberti, Joseph</creatorcontrib><creatorcontrib>Chenoweth, Carol</creatorcontrib><title>Risk Factors for Anaerobic Bloodstream Infections in Bone Marrow Transplant Recipients</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>The incidence of anaerobic bloodstream infections (BSI) in patients who underwent bone marrow transplantation (BMT) recently increased at our institution. A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiological characteristics, epidemiology, and outcome of anaerobic BSI and to identify independent risk factors for infection. Anaerobic BSI occurred in 23 patients, for a rate of 4 BSIs per 100 BMT procedures, and it accounted for 17% of all BSIs that occurred during the study period. Infection occurred at a mean (± standard deviation) of 7 ± 4 days after BMT and 7 ± 5 days after the onset of neutropenia. Fusobacterium nucleatum was the most frequently isolated pathogen (in 17 patients), followed by Leptotrichia buccalis (in 4), Clostridium septicum (in 1), and Clostridium tertium (in 1). Two case patients (9%) died. Severity of mucositis was an independent predictor of anaerobic BSI (odds ratio, 4.4; P = .01). Controlling mucositis is critical for the prevention of anaerobic BSI in this patient population.</description><subject>Adult</subject><subject>Agranulocytosis - complications</subject><subject>Anaerobic bacteria</subject><subject>Antimicrobials</subject><subject>Bacteremia</subject><subject>Bacteremia - etiology</subject><subject>Bacteria, Anaerobic</subject><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>Case-Control Studies</subject><subject>Diarrhea</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Logistic Models</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mucositis</subject><subject>Mucous Membrane - immunology</subject><subject>Neutropenia</subject><subject>Predisposing factors</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9r1EAUxYMotlb9BCIjFN-iM5nMv8fu0m0LrUqtsvgyTCZ3YNpsJs7Non77ZsnS-iI-3QvnxzmXc4viNaMfGNXyI68qYcST4pAJrkopDHs67VTostZcHxQvEG8pZUxT8bw4YKzmWhtzWHy_jnhHVs6PKSMJKZOT3kFOTfRk0aXU4pjBbchFH8CPMfVIYk8WqQdy5XJOv8hNdj0OnetHcg0-DhH6EV8Wz4LrEF7t51HxbXV6szwvLz-fXSxPLksvmB7Lppah1g01wTcmtB68UEBrE1jlddOAUdRTrRmV4JkB4Ea10jsvmZGtCZIfFe9n3yGnn1vA0W4ieuimcyBt0SpqNJOi-i_ItKwUVfUj6HNCzBDskOPG5T-WUbur2s5VT-DbveO22UD7iO27nYDjPeDQuy5MPfmIf9kZratd4LsZS9vh31lvZuYWpz89UHWtK8V3SeUsRxzh94Ps8p2Viithz9c_7Jer9erT4uvaLvk9T3-oYg</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Lark, Rebecca L.</creator><creator>McNeil, Shelly A.</creator><creator>VanderHyde, Kristi</creator><creator>Noorani, Zehra</creator><creator>Uberti, Joseph</creator><creator>Chenoweth, Carol</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Risk Factors for Anaerobic Bloodstream Infections in Bone Marrow Transplant Recipients</title><author>Lark, Rebecca L. ; McNeil, Shelly A. ; VanderHyde, Kristi ; Noorani, Zehra ; Uberti, Joseph ; Chenoweth, Carol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-b46f48b09fcb9fdcec57e049f12c8bbe970c088106ec19ee397d6cac6196d9f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Agranulocytosis - complications</topic><topic>Anaerobic bacteria</topic><topic>Antimicrobials</topic><topic>Bacteremia</topic><topic>Bacteremia - etiology</topic><topic>Bacteria, Anaerobic</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Bone marrow</topic><topic>Bone Marrow Transplantation - adverse effects</topic><topic>Case-Control Studies</topic><topic>Diarrhea</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Logistic Models</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mucositis</topic><topic>Mucous Membrane - immunology</topic><topic>Neutropenia</topic><topic>Predisposing factors</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lark, Rebecca L.</creatorcontrib><creatorcontrib>McNeil, Shelly A.</creatorcontrib><creatorcontrib>VanderHyde, Kristi</creatorcontrib><creatorcontrib>Noorani, Zehra</creatorcontrib><creatorcontrib>Uberti, Joseph</creatorcontrib><creatorcontrib>Chenoweth, Carol</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lark, Rebecca L.</au><au>McNeil, Shelly A.</au><au>VanderHyde, Kristi</au><au>Noorani, Zehra</au><au>Uberti, Joseph</au><au>Chenoweth, Carol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Anaerobic Bloodstream Infections in Bone Marrow Transplant Recipients</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>33</volume><issue>3</issue><spage>338</spage><epage>343</epage><pages>338-343</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>The incidence of anaerobic bloodstream infections (BSI) in patients who underwent bone marrow transplantation (BMT) recently increased at our institution. A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiological characteristics, epidemiology, and outcome of anaerobic BSI and to identify independent risk factors for infection. Anaerobic BSI occurred in 23 patients, for a rate of 4 BSIs per 100 BMT procedures, and it accounted for 17% of all BSIs that occurred during the study period. Infection occurred at a mean (± standard deviation) of 7 ± 4 days after BMT and 7 ± 5 days after the onset of neutropenia. Fusobacterium nucleatum was the most frequently isolated pathogen (in 17 patients), followed by Leptotrichia buccalis (in 4), Clostridium septicum (in 1), and Clostridium tertium (in 1). Two case patients (9%) died. Severity of mucositis was an independent predictor of anaerobic BSI (odds ratio, 4.4; P = .01). Controlling mucositis is critical for the prevention of anaerobic BSI in this patient population.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11438899</pmid><doi>10.1086/322595</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Agranulocytosis - complications Anaerobic bacteria Antimicrobials Bacteremia Bacteremia - etiology Bacteria, Anaerobic Bacterial diseases Bacterial sepsis Biological and medical sciences Blood Bone marrow Bone Marrow Transplantation - adverse effects Case-Control Studies Diarrhea Female Human bacterial diseases Humans Immunocompromised Host Infections Infectious diseases Logistic Models Major Articles Male Medical sciences Mucositis Mucous Membrane - immunology Neutropenia Predisposing factors Retrospective Studies Risk Factors |
title | Risk Factors for Anaerobic Bloodstream Infections in Bone Marrow Transplant Recipients |
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