Risk Factors for Anaerobic Bloodstream Infections in Bone Marrow Transplant Recipients

The incidence of anaerobic bloodstream infections (BSI) in patients who underwent bone marrow transplantation (BMT) recently increased at our institution. A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiologi...

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Veröffentlicht in:Clinical infectious diseases 2001-08, Vol.33 (3), p.338-343
Hauptverfasser: Lark, Rebecca L., McNeil, Shelly A., VanderHyde, Kristi, Noorani, Zehra, Uberti, Joseph, Chenoweth, Carol
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container_end_page 343
container_issue 3
container_start_page 338
container_title Clinical infectious diseases
container_volume 33
creator Lark, Rebecca L.
McNeil, Shelly A.
VanderHyde, Kristi
Noorani, Zehra
Uberti, Joseph
Chenoweth, Carol
description The incidence of anaerobic bloodstream infections (BSI) in patients who underwent bone marrow transplantation (BMT) recently increased at our institution. A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiological characteristics, epidemiology, and outcome of anaerobic BSI and to identify independent risk factors for infection. Anaerobic BSI occurred in 23 patients, for a rate of 4 BSIs per 100 BMT procedures, and it accounted for 17% of all BSIs that occurred during the study period. Infection occurred at a mean (± standard deviation) of 7 ± 4 days after BMT and 7 ± 5 days after the onset of neutropenia. Fusobacterium nucleatum was the most frequently isolated pathogen (in 17 patients), followed by Leptotrichia buccalis (in 4), Clostridium septicum (in 1), and Clostridium tertium (in 1). Two case patients (9%) died. Severity of mucositis was an independent predictor of anaerobic BSI (odds ratio, 4.4; P = .01). Controlling mucositis is critical for the prevention of anaerobic BSI in this patient population.
doi_str_mv 10.1086/322595
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A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiological characteristics, epidemiology, and outcome of anaerobic BSI and to identify independent risk factors for infection. Anaerobic BSI occurred in 23 patients, for a rate of 4 BSIs per 100 BMT procedures, and it accounted for 17% of all BSIs that occurred during the study period. Infection occurred at a mean (± standard deviation) of 7 ± 4 days after BMT and 7 ± 5 days after the onset of neutropenia. Fusobacterium nucleatum was the most frequently isolated pathogen (in 17 patients), followed by Leptotrichia buccalis (in 4), Clostridium septicum (in 1), and Clostridium tertium (in 1). Two case patients (9%) died. Severity of mucositis was an independent predictor of anaerobic BSI (odds ratio, 4.4; P = .01). 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A retrospective case-control study of patients undergoing BMT from January 1995 through December 1998 was performed to determine the microbiological characteristics, epidemiology, and outcome of anaerobic BSI and to identify independent risk factors for infection. Anaerobic BSI occurred in 23 patients, for a rate of 4 BSIs per 100 BMT procedures, and it accounted for 17% of all BSIs that occurred during the study period. Infection occurred at a mean (± standard deviation) of 7 ± 4 days after BMT and 7 ± 5 days after the onset of neutropenia. Fusobacterium nucleatum was the most frequently isolated pathogen (in 17 patients), followed by Leptotrichia buccalis (in 4), Clostridium septicum (in 1), and Clostridium tertium (in 1). Two case patients (9%) died. Severity of mucositis was an independent predictor of anaerobic BSI (odds ratio, 4.4; P = .01). 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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current)
subjects Adult
Agranulocytosis - complications
Anaerobic bacteria
Antimicrobials
Bacteremia
Bacteremia - etiology
Bacteria, Anaerobic
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Blood
Bone marrow
Bone Marrow Transplantation - adverse effects
Case-Control Studies
Diarrhea
Female
Human bacterial diseases
Humans
Immunocompromised Host
Infections
Infectious diseases
Logistic Models
Major Articles
Male
Medical sciences
Mucositis
Mucous Membrane - immunology
Neutropenia
Predisposing factors
Retrospective Studies
Risk Factors
title Risk Factors for Anaerobic Bloodstream Infections in Bone Marrow Transplant Recipients
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