In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles

The primary objective of this study was to investigate the feasibility of using PEO-PPO-PEO non-ionic copolymeric micelles as a carrier for eye-drop gene delivery of plasmid DNA with lacZ gene in vivo. Using pyrene fluorescence probe methods, zeta potential, and dynamic light scattering test (DLS),...

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Veröffentlicht in:	Gene therapy 2001-07, Vol.8 (13), p.999-1004
Hauptverfasser:	LIAW, J, CHANG, S-F, HSIAO, F-C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Chlorophenol Conjunctiva Copolymers Cytochalasin B - pharmacology Deoxyribonucleic acid DNA Edetic Acid - pharmacology Endocytosis Ethylene Eye Eye - metabolism Feasibility Studies Fluorescent Dyes Fundamental and applied biological sciences. Psychology Gene expression Gene therapy Gene transfer Gene Transfer Techniques Health. Pharmaceutical industry Industrial applications and implications. Economical aspects LacZ gene Light Light scattering Male Medical sciences Mice Mice, Inbred BALB C Mice, Nude Micelles Ophthalmic Solutions Plasmids Polyethylene Glycols Polyethylene oxide polypropylene oxide Propylene Glycols Propylene oxide Rabbits Rectus muscle Scattering, Radiation Topical application Transfection Transfusions. Complications. Transfusion reactions. Cell and gene therapy Zeta potential
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