Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30

We studied 31 nondiabetic, habitually ([ge ]5 years) morbidly obese subjects (mean [plusmn] SD body mass index [BMI] 43 [plusmn] 8.7, median 43). Our specific aim was to determine whether metformin (2.55 g/d for 28 weeks) would ameliorate morbid obesity and reduce centripetal obesity; lipid and lipo...

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