Leptin concentrations in Prader-Willi syndrome before and after growth hormone replacement
OBJECTIVE This study explored leptin concentrations in Prader‐Willi syndrome (PWS), a genetic disorder characterized by significant obesity and presumed hypothalamic dysfunction. The potential interaction of leptin metabolism with the growth hormone (GH) axis was also studied. STUDY DESIGN Plasma le...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2000-01, Vol.52 (1), p.101-105 |
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| container_title | Clinical endocrinology (Oxford) |
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| creator | Myers, Susan E. Davis, Ajuah Whitman, Barbara Y. Santiago, Julio V. Landt, Michael |
| description | OBJECTIVE
This study explored leptin concentrations in Prader‐Willi syndrome (PWS), a genetic disorder characterized by significant obesity and presumed hypothalamic dysfunction. The potential interaction of leptin metabolism with the growth hormone (GH) axis was also studied.
STUDY DESIGN
Plasma leptin concentrations and percent body fat were determined by radioimmunoassay and dual energy x‐ray absorptionmetry, respectively, in 23 children with Prader‐Willi syndrome and 23 children with exogenous obesity.
RESULTS
Log plasma leptin concentrations were positively correlated with percentage body fat in PWS (r = 0.844) and exogenous obesity (r = 0.869). When the regression lines for the two groups were compared, there were no differences in their slopes (P = 0.737) or intercepts (P = 0.701). Administration of recombinant human growth hormone to PWS children for 12 months significantly reduced both percentage body fat and plasma leptin concentrations, but the relationship of log plasma leptin to percentage body fat was unchanged.
CONCLUSION
Prader‐Willi syndrome is not accompanied by deranged leptin concentrations and there was no evidence of an interaction of the GH axis with leptin metabolism in these GH‐deficient children. |
| doi_str_mv | 10.1046/j.1365-2265.2000.00868.x |
| format | Article |
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This study explored leptin concentrations in Prader‐Willi syndrome (PWS), a genetic disorder characterized by significant obesity and presumed hypothalamic dysfunction. The potential interaction of leptin metabolism with the growth hormone (GH) axis was also studied.
STUDY DESIGN
Plasma leptin concentrations and percent body fat were determined by radioimmunoassay and dual energy x‐ray absorptionmetry, respectively, in 23 children with Prader‐Willi syndrome and 23 children with exogenous obesity.
RESULTS
Log plasma leptin concentrations were positively correlated with percentage body fat in PWS (r = 0.844) and exogenous obesity (r = 0.869). When the regression lines for the two groups were compared, there were no differences in their slopes (P = 0.737) or intercepts (P = 0.701). Administration of recombinant human growth hormone to PWS children for 12 months significantly reduced both percentage body fat and plasma leptin concentrations, but the relationship of log plasma leptin to percentage body fat was unchanged.
CONCLUSION
Prader‐Willi syndrome is not accompanied by deranged leptin concentrations and there was no evidence of an interaction of the GH axis with leptin metabolism in these GH‐deficient children.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1046/j.1365-2265.2000.00868.x</identifier><identifier>PMID: 10651760</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Body Composition ; Child ; Complex syndromes ; Female ; Growth Hormone - therapeutic use ; Humans ; Leptin - blood ; Male ; Medical genetics ; Medical sciences ; Obesity - blood ; Obesity - physiopathology ; Prader-Willi Syndrome - blood ; Prader-Willi Syndrome - drug therapy ; Prader-Willi Syndrome - physiopathology ; Regression Analysis</subject><ispartof>Clinical endocrinology (Oxford), 2000-01, Vol.52 (1), p.101-105</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jan 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4588-fa0a5ddd51cb4dbaa333d8cf3e9568444a5202989a2f7db11e2ade5f8708bd0f3</citedby><cites>FETCH-LOGICAL-c4588-fa0a5ddd51cb4dbaa333d8cf3e9568444a5202989a2f7db11e2ade5f8708bd0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2265.2000.00868.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2265.2000.00868.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,4025,27924,27925,27926,45575,45576</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1266519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10651760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Myers, Susan E.</creatorcontrib><creatorcontrib>Davis, Ajuah</creatorcontrib><creatorcontrib>Whitman, Barbara Y.</creatorcontrib><creatorcontrib>Santiago, Julio V.</creatorcontrib><creatorcontrib>Landt, Michael</creatorcontrib><title>Leptin concentrations in Prader-Willi syndrome before and after growth hormone replacement</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clinical Endocrinology</addtitle><description>OBJECTIVE
This study explored leptin concentrations in Prader‐Willi syndrome (PWS), a genetic disorder characterized by significant obesity and presumed hypothalamic dysfunction. The potential interaction of leptin metabolism with the growth hormone (GH) axis was also studied.
STUDY DESIGN
Plasma leptin concentrations and percent body fat were determined by radioimmunoassay and dual energy x‐ray absorptionmetry, respectively, in 23 children with Prader‐Willi syndrome and 23 children with exogenous obesity.
RESULTS
Log plasma leptin concentrations were positively correlated with percentage body fat in PWS (r = 0.844) and exogenous obesity (r = 0.869). When the regression lines for the two groups were compared, there were no differences in their slopes (P = 0.737) or intercepts (P = 0.701). Administration of recombinant human growth hormone to PWS children for 12 months significantly reduced both percentage body fat and plasma leptin concentrations, but the relationship of log plasma leptin to percentage body fat was unchanged.
CONCLUSION
Prader‐Willi syndrome is not accompanied by deranged leptin concentrations and there was no evidence of an interaction of the GH axis with leptin metabolism in these GH‐deficient children.</description><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Child</subject><subject>Complex syndromes</subject><subject>Female</subject><subject>Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Obesity - blood</subject><subject>Obesity - physiopathology</subject><subject>Prader-Willi Syndrome - blood</subject><subject>Prader-Willi Syndrome - drug therapy</subject><subject>Prader-Willi Syndrome - physiopathology</subject><subject>Regression Analysis</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFuL1DAYhoMo7rj6FySIeNeaNM2h4I077kEYR8HDgjchzcHt2CZj0mFn_v2mdljFK68Skud9v48HAIhRiVHNXm9KTBgtqorRskIIlQgJJsr9A7C4_3gIFoggVCDG6hPwJKVNBqlA_DE4wYhRzBlagO8rux07D3Xw2voxqrELPsH88ikqY2Nx3fV9B9PBmxgGC1vrQrRQeQOVG22EP2K4HW_gTYhD8BZGu-2VtkPuegoeOdUn--x4noKvF-dfllfF6uPl--XbVaFrKkThFFLUGEOxbmvTKkUIMUI7YhvKRF3XilaoakSjKsdNi7Gt8mLUCY5Ea5Ajp-DV3LuN4dfOplEOXdK275W3YZckRw3nXPAMvvgH3IRd9Hk3iRvBG0KaCRIzpGNIKVont7EbVDxIjOQkX27k5FhOjuUkX_6WL_c5-vzYv2sHa_4KzrYz8PIIqKRV76Lyukt_uIplsMnYmxm77Xp7-O_5cnm-zpccL-Z4l0a7v4-r-FMyTjiV1-tLebU-W337_GEp35E7IoOvmw</recordid><startdate>200001</startdate><enddate>200001</enddate><creator>Myers, Susan E.</creator><creator>Davis, Ajuah</creator><creator>Whitman, Barbara Y.</creator><creator>Santiago, Julio V.</creator><creator>Landt, Michael</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200001</creationdate><title>Leptin concentrations in Prader-Willi syndrome before and after growth hormone replacement</title><author>Myers, Susan E. ; Davis, Ajuah ; Whitman, Barbara Y. ; Santiago, Julio V. ; Landt, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4588-fa0a5ddd51cb4dbaa333d8cf3e9568444a5202989a2f7db11e2ade5f8708bd0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Child</topic><topic>Complex syndromes</topic><topic>Female</topic><topic>Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Obesity - blood</topic><topic>Obesity - physiopathology</topic><topic>Prader-Willi Syndrome - blood</topic><topic>Prader-Willi Syndrome - drug therapy</topic><topic>Prader-Willi Syndrome - physiopathology</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Myers, Susan E.</creatorcontrib><creatorcontrib>Davis, Ajuah</creatorcontrib><creatorcontrib>Whitman, Barbara Y.</creatorcontrib><creatorcontrib>Santiago, Julio V.</creatorcontrib><creatorcontrib>Landt, Michael</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Myers, Susan E.</au><au>Davis, Ajuah</au><au>Whitman, Barbara Y.</au><au>Santiago, Julio V.</au><au>Landt, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin concentrations in Prader-Willi syndrome before and after growth hormone replacement</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clinical Endocrinology</addtitle><date>2000-01</date><risdate>2000</risdate><volume>52</volume><issue>1</issue><spage>101</spage><epage>105</epage><pages>101-105</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>OBJECTIVE
This study explored leptin concentrations in Prader‐Willi syndrome (PWS), a genetic disorder characterized by significant obesity and presumed hypothalamic dysfunction. The potential interaction of leptin metabolism with the growth hormone (GH) axis was also studied.
STUDY DESIGN
Plasma leptin concentrations and percent body fat were determined by radioimmunoassay and dual energy x‐ray absorptionmetry, respectively, in 23 children with Prader‐Willi syndrome and 23 children with exogenous obesity.
RESULTS
Log plasma leptin concentrations were positively correlated with percentage body fat in PWS (r = 0.844) and exogenous obesity (r = 0.869). When the regression lines for the two groups were compared, there were no differences in their slopes (P = 0.737) or intercepts (P = 0.701). Administration of recombinant human growth hormone to PWS children for 12 months significantly reduced both percentage body fat and plasma leptin concentrations, but the relationship of log plasma leptin to percentage body fat was unchanged.
CONCLUSION
Prader‐Willi syndrome is not accompanied by deranged leptin concentrations and there was no evidence of an interaction of the GH axis with leptin metabolism in these GH‐deficient children.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>10651760</pmid><doi>10.1046/j.1365-2265.2000.00868.x</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Biological and medical sciences Body Composition Child Complex syndromes Female Growth Hormone - therapeutic use Humans Leptin - blood Male Medical genetics Medical sciences Obesity - blood Obesity - physiopathology Prader-Willi Syndrome - blood Prader-Willi Syndrome - drug therapy Prader-Willi Syndrome - physiopathology Regression Analysis |
| title | Leptin concentrations in Prader-Willi syndrome before and after growth hormone replacement |
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