Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese
The polymorphism in the ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the ADH2 and ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (H...
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| Veröffentlicht in: | Cancer letters 2000-02, Vol.149 (1), p.69-76 |
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| creator | Takeshita, Tatsuya Yang, Xing Inoue, Yoshiki Sato, Shigeaki Morimoto, Kanehisa |
| description | The polymorphism in the
ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the
ADH2 and
ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in a case-control study in Japan. One hundred and two patients with HCC (85 males and 17 females) and 125 control subjects (101 males and 24 females) were enrolled in the study. Higher cumulative amounts of alcohol consumption (drink-years of ≥40 drinks/day×year) showed a significant association with HCC development (odds ratio, OR=2.7; 95% CI=1.3–5.5, adjusted for age and smoking). By contrast, we could find no association of the
ALDH2 genotypes with HCC development (adjusted OR for
ALDH2*1/*2=1.1; 95% CI=0.6–2.1). Likewise, the
ADH2 genotypes were not associated with HCC development (adjusted OR for
ADH2*2/*2=0.8; 95% CI=0.5–1.5). The present results do not support a contribution of acetaldehyde, an active metabolite of ethanol, to HCC development and rather indicate a direct involvement of ethanol in hepatocarcinogenesis. |
| doi_str_mv | 10.1016/S0304-3835(99)00343-2 |
| format | Article |
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ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the
ADH2 and
ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in a case-control study in Japan. One hundred and two patients with HCC (85 males and 17 females) and 125 control subjects (101 males and 24 females) were enrolled in the study. Higher cumulative amounts of alcohol consumption (drink-years of ≥40 drinks/day×year) showed a significant association with HCC development (odds ratio, OR=2.7; 95% CI=1.3–5.5, adjusted for age and smoking). By contrast, we could find no association of the
ALDH2 genotypes with HCC development (adjusted OR for
ALDH2*1/*2=1.1; 95% CI=0.6–2.1). Likewise, the
ADH2 genotypes were not associated with HCC development (adjusted OR for
ADH2*2/*2=0.8; 95% CI=0.5–1.5). The present results do not support a contribution of acetaldehyde, an active metabolite of ethanol, to HCC development and rather indicate a direct involvement of ethanol in hepatocarcinogenesis.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(99)00343-2</identifier><identifier>PMID: 10737710</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acetaldehyde ; Aged ; Alcohol dehydrogenase ; Alcohol Dehydrogenase - biosynthesis ; Alcohol Dehydrogenase - genetics ; Alcohol drinking ; Alcohol Drinking - adverse effects ; Aldehyde dehydrogenase ; Aldehyde Dehydrogenase - biosynthesis ; Aldehyde Dehydrogenase - genetics ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - genetics ; Case-Control Studies ; Female ; Foods and miscellaneous ; Genetic Predisposition to Disease ; Hepatitis C virus ; Hepatocellular carcinoma ; Humans ; Japan - epidemiology ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Liver Neoplasms - genetics ; Male ; Medical sciences ; Middle Aged ; Risk ; Risk Factors ; Tumors</subject><ispartof>Cancer letters, 2000-02, Vol.149 (1), p.69-76</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-15a13a6b662763706484cc03eb6eb9b2873b57c4c36ee24c3c464773c37136903</citedby><cites>FETCH-LOGICAL-c456t-15a13a6b662763706484cc03eb6eb9b2873b57c4c36ee24c3c464773c37136903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3835(99)00343-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1310774$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10737710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takeshita, Tatsuya</creatorcontrib><creatorcontrib>Yang, Xing</creatorcontrib><creatorcontrib>Inoue, Yoshiki</creatorcontrib><creatorcontrib>Sato, Shigeaki</creatorcontrib><creatorcontrib>Morimoto, Kanehisa</creatorcontrib><title>Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The polymorphism in the
ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the
ADH2 and
ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in a case-control study in Japan. One hundred and two patients with HCC (85 males and 17 females) and 125 control subjects (101 males and 24 females) were enrolled in the study. Higher cumulative amounts of alcohol consumption (drink-years of ≥40 drinks/day×year) showed a significant association with HCC development (odds ratio, OR=2.7; 95% CI=1.3–5.5, adjusted for age and smoking). By contrast, we could find no association of the
ALDH2 genotypes with HCC development (adjusted OR for
ALDH2*1/*2=1.1; 95% CI=0.6–2.1). Likewise, the
ADH2 genotypes were not associated with HCC development (adjusted OR for
ADH2*2/*2=0.8; 95% CI=0.5–1.5). The present results do not support a contribution of acetaldehyde, an active metabolite of ethanol, to HCC development and rather indicate a direct involvement of ethanol in hepatocarcinogenesis.</description><subject>Acetaldehyde</subject><subject>Aged</subject><subject>Alcohol dehydrogenase</subject><subject>Alcohol Dehydrogenase - biosynthesis</subject><subject>Alcohol Dehydrogenase - genetics</subject><subject>Alcohol drinking</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Aldehyde dehydrogenase</subject><subject>Aldehyde Dehydrogenase - biosynthesis</subject><subject>Aldehyde Dehydrogenase - genetics</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Foods and miscellaneous</subject><subject>Genetic Predisposition to Disease</subject><subject>Hepatitis C virus</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFuLFDEQRoMo7rj6E5Q8iChsa6WTTrqfZFgvqwwIXp5DurpmJ25P0iY9yv57MxfUN5-qKE5VfRzGHgt4KUDoV19AgqpkK5vnXfcCQCpZ1XfYQrSmrkzXwl22-IOcsQc5fweARpnmPjsTYKQxAhYsfabRzT6GvPET72n-RRS4GzFu4siH5MOND9cXfPnmquYuDHy52nfXFOJ8O1G-OAyTzzd8HRPf0OTmiDSOu9Elji6hD3HruA_8o5tcoEwP2b21GzM9OtVz9u3d26-XV9Xq0_sPl8tVharRcyUaJ6TTvda10dKAVq1CBEm9pr7r69bIvjGoUGqiuhRUWhkjURohdQfynD073p1S_LGjPNutz_toJUXcZWugK7iQBWyOIKaYc6K1nZLfunRrBdi9bHuQbfcmbdfZg2xbl70npwe7fkvDP1tHuwV4egJcRjeukwvo819OFtKogr0-YlRs_PSUbEZPAWnwiXC2Q_T_SfIbEc-aFA</recordid><startdate>20000228</startdate><enddate>20000228</enddate><creator>Takeshita, Tatsuya</creator><creator>Yang, Xing</creator><creator>Inoue, Yoshiki</creator><creator>Sato, Shigeaki</creator><creator>Morimoto, Kanehisa</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000228</creationdate><title>Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese</title><author>Takeshita, Tatsuya ; Yang, Xing ; Inoue, Yoshiki ; Sato, Shigeaki ; Morimoto, Kanehisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-15a13a6b662763706484cc03eb6eb9b2873b57c4c36ee24c3c464773c37136903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acetaldehyde</topic><topic>Aged</topic><topic>Alcohol dehydrogenase</topic><topic>Alcohol Dehydrogenase - biosynthesis</topic><topic>Alcohol Dehydrogenase - genetics</topic><topic>Alcohol drinking</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Aldehyde dehydrogenase</topic><topic>Aldehyde Dehydrogenase - biosynthesis</topic><topic>Aldehyde Dehydrogenase - genetics</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Foods and miscellaneous</topic><topic>Genetic Predisposition to Disease</topic><topic>Hepatitis C virus</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takeshita, Tatsuya</creatorcontrib><creatorcontrib>Yang, Xing</creatorcontrib><creatorcontrib>Inoue, Yoshiki</creatorcontrib><creatorcontrib>Sato, Shigeaki</creatorcontrib><creatorcontrib>Morimoto, Kanehisa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeshita, Tatsuya</au><au>Yang, Xing</au><au>Inoue, Yoshiki</au><au>Sato, Shigeaki</au><au>Morimoto, Kanehisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2000-02-28</date><risdate>2000</risdate><volume>149</volume><issue>1</issue><spage>69</spage><epage>76</epage><pages>69-76</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The polymorphism in the
ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the
ADH2 and
ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in a case-control study in Japan. One hundred and two patients with HCC (85 males and 17 females) and 125 control subjects (101 males and 24 females) were enrolled in the study. Higher cumulative amounts of alcohol consumption (drink-years of ≥40 drinks/day×year) showed a significant association with HCC development (odds ratio, OR=2.7; 95% CI=1.3–5.5, adjusted for age and smoking). By contrast, we could find no association of the
ALDH2 genotypes with HCC development (adjusted OR for
ALDH2*1/*2=1.1; 95% CI=0.6–2.1). Likewise, the
ADH2 genotypes were not associated with HCC development (adjusted OR for
ADH2*2/*2=0.8; 95% CI=0.5–1.5). The present results do not support a contribution of acetaldehyde, an active metabolite of ethanol, to HCC development and rather indicate a direct involvement of ethanol in hepatocarcinogenesis.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10737710</pmid><doi>10.1016/S0304-3835(99)00343-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Acetaldehyde Aged Alcohol dehydrogenase Alcohol Dehydrogenase - biosynthesis Alcohol Dehydrogenase - genetics Alcohol drinking Alcohol Drinking - adverse effects Aldehyde dehydrogenase Aldehyde Dehydrogenase - biosynthesis Aldehyde Dehydrogenase - genetics Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - genetics Case-Control Studies Female Foods and miscellaneous Genetic Predisposition to Disease Hepatitis C virus Hepatocellular carcinoma Humans Japan - epidemiology Liver Neoplasms - epidemiology Liver Neoplasms - etiology Liver Neoplasms - genetics Male Medical sciences Middle Aged Risk Risk Factors Tumors |
| title | Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese |
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