Online Detection of Myocardial Ischemia by Near Infrared Spectroscopy with a Fiberoptic Catheter
The interruption of myocardial O2-supply in acute myocardial ischemia causes differences in coronary venous O2-content. In this study, the oxygenation status of coronary sinus blood is detected in myocardial ischemia by near infrared (NIR) spectroscopy. For the intravascular application, a new fiber...
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| Veröffentlicht in: | The Thoracic and cardiovascular surgeon 2001-06, Vol.49 (3), p.162-166 |
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| container_title | The Thoracic and cardiovascular surgeon |
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| creator | Baykut, D. Gebhard, M. M. Bölükoglu, H. Kadipasaoglu, K. Hennes, S. Frazier, O. H. Krian, A. |
| description | The interruption of myocardial O2-supply in acute myocardial ischemia causes differences in coronary venous O2-content. In this study, the oxygenation status of coronary sinus blood is detected in myocardial ischemia by near infrared (NIR) spectroscopy.
For the intravascular application, a new fiberoptic catheter is developed. After calibration of the catheter by perfusion of blood with standardized gas mixtures in an in vitro experiment, the in vivo application was performed in 12 domestic pigs. The catheter was placed into coronary sinus and an anterior ischemia was induced by temporary occlusion of LAD. NIR graphs and hemodynamic data were obtained for 90 min ischemia and 90 min reperfusion time.
Main NIR-spectroscopic differences between oxygenated and de-oxygenated hemoglobin took place in O2-concentrations less than 30%. Coronary sinus NIR spectra of hemoglobin-oxygen binding showed significant, reproducible differences between pre-ischemia, LAD-occlusion and reperfusion. NIR graphs also show variations related to CO2-concentration, pH and temperature.
The intravascular application of NIR spectroscopy could be a reliable tool in detection and follow-up of acute myocardial ischemia and infarction. |
| doi_str_mv | 10.1055/s-2001-14294 |
| format | Article |
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For the intravascular application, a new fiberoptic catheter is developed. After calibration of the catheter by perfusion of blood with standardized gas mixtures in an in vitro experiment, the in vivo application was performed in 12 domestic pigs. The catheter was placed into coronary sinus and an anterior ischemia was induced by temporary occlusion of LAD. NIR graphs and hemodynamic data were obtained for 90 min ischemia and 90 min reperfusion time.
Main NIR-spectroscopic differences between oxygenated and de-oxygenated hemoglobin took place in O2-concentrations less than 30%. Coronary sinus NIR spectra of hemoglobin-oxygen binding showed significant, reproducible differences between pre-ischemia, LAD-occlusion and reperfusion. NIR graphs also show variations related to CO2-concentration, pH and temperature.
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For the intravascular application, a new fiberoptic catheter is developed. After calibration of the catheter by perfusion of blood with standardized gas mixtures in an in vitro experiment, the in vivo application was performed in 12 domestic pigs. The catheter was placed into coronary sinus and an anterior ischemia was induced by temporary occlusion of LAD. NIR graphs and hemodynamic data were obtained for 90 min ischemia and 90 min reperfusion time.
Main NIR-spectroscopic differences between oxygenated and de-oxygenated hemoglobin took place in O2-concentrations less than 30%. Coronary sinus NIR spectra of hemoglobin-oxygen binding showed significant, reproducible differences between pre-ischemia, LAD-occlusion and reperfusion. NIR graphs also show variations related to CO2-concentration, pH and temperature.
The intravascular application of NIR spectroscopy could be a reliable tool in detection and follow-up of acute myocardial ischemia and infarction.</description><subject>Animals</subject><subject>Arterial Occlusive Diseases - complications</subject><subject>Arterial Occlusive Diseases - diagnosis</subject><subject>Arterial Occlusive Diseases - surgery</subject><subject>Arteries - surgery</subject><subject>Carbon Dioxide - blood</subject><subject>Cardiac Surgical Procedures - instrumentation</subject><subject>Catheters, Indwelling</subject><subject>Coronary Vessels - surgery</subject><subject>Electrocardiography</subject><subject>Models, Animal</subject><subject>Myocardial Ischemia - complications</subject><subject>Myocardial Ischemia - diagnosis</subject><subject>Myocardial Ischemia - surgery</subject><subject>Original Cardiovascular</subject><subject>Oxygen - blood</subject><subject>Spectroscopy, Near-Infrared - instrumentation</subject><subject>Swine</subject><subject>Time Factors</subject><issn>0171-6425</issn><issn>1439-1902</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1PwzAURS0EoqWwMSNPLBDwR5zEIyoUKhU6ALNxnBfVKImDnQr13-PSSixMbznv6N6L0DklN5QIcRsSRghNaMpkeoDGNOUyoZKwQzQmNKdJljIxQichfEYsLQp5jEY0UizNxRh9LLvGdoDvYQAzWNdhV-PnjTPaV1Y3eB7MClqrcbnBL6A9nne11x4q_NrHB--Ccf0Gf9thhTWe2RK86wdr8FQPq-j0p-io1k2As_2doPfZw9v0KVksH-fTu0ViOONDkjITg2ecQ8aMzAtGDIUiq4TkmZQ89qlEqWkl8yojnPKCl1zwSnJRFqY2GZ-gy5239-5rDWFQrQ0GmkZ34NZB5UTmORM8gtc70MTwwUOtem9b7TeKErVdVAW1XVT9Lhrxi713XbZQ_cH7CSNwtQOGlYUW1Kdb-y42_V_3A_CofVs</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Baykut, D.</creator><creator>Gebhard, M. 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M.</creatorcontrib><creatorcontrib>Bölükoglu, H.</creatorcontrib><creatorcontrib>Kadipasaoglu, K.</creatorcontrib><creatorcontrib>Hennes, S.</creatorcontrib><creatorcontrib>Frazier, O. H.</creatorcontrib><creatorcontrib>Krian, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Thoracic and cardiovascular surgeon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baykut, D.</au><au>Gebhard, M. M.</au><au>Bölükoglu, H.</au><au>Kadipasaoglu, K.</au><au>Hennes, S.</au><au>Frazier, O. H.</au><au>Krian, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Online Detection of Myocardial Ischemia by Near Infrared Spectroscopy with a Fiberoptic Catheter</atitle><jtitle>The Thoracic and cardiovascular surgeon</jtitle><addtitle>Thorac cardiovasc Surg</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>49</volume><issue>3</issue><spage>162</spage><epage>166</epage><pages>162-166</pages><issn>0171-6425</issn><eissn>1439-1902</eissn><abstract>The interruption of myocardial O2-supply in acute myocardial ischemia causes differences in coronary venous O2-content. In this study, the oxygenation status of coronary sinus blood is detected in myocardial ischemia by near infrared (NIR) spectroscopy.
For the intravascular application, a new fiberoptic catheter is developed. After calibration of the catheter by perfusion of blood with standardized gas mixtures in an in vitro experiment, the in vivo application was performed in 12 domestic pigs. The catheter was placed into coronary sinus and an anterior ischemia was induced by temporary occlusion of LAD. NIR graphs and hemodynamic data were obtained for 90 min ischemia and 90 min reperfusion time.
Main NIR-spectroscopic differences between oxygenated and de-oxygenated hemoglobin took place in O2-concentrations less than 30%. Coronary sinus NIR spectra of hemoglobin-oxygen binding showed significant, reproducible differences between pre-ischemia, LAD-occlusion and reperfusion. NIR graphs also show variations related to CO2-concentration, pH and temperature.
The intravascular application of NIR spectroscopy could be a reliable tool in detection and follow-up of acute myocardial ischemia and infarction.</abstract><cop>Germany</cop><pmid>11432475</pmid><doi>10.1055/s-2001-14294</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals Arterial Occlusive Diseases - complications Arterial Occlusive Diseases - diagnosis Arterial Occlusive Diseases - surgery Arteries - surgery Carbon Dioxide - blood Cardiac Surgical Procedures - instrumentation Catheters, Indwelling Coronary Vessels - surgery Electrocardiography Models, Animal Myocardial Ischemia - complications Myocardial Ischemia - diagnosis Myocardial Ischemia - surgery Original Cardiovascular Oxygen - blood Spectroscopy, Near-Infrared - instrumentation Swine Time Factors |
| title | Online Detection of Myocardial Ischemia by Near Infrared Spectroscopy with a Fiberoptic Catheter |
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