Nitric oxide inhibition increases matrix metalloproteinase–9 expression by rat aortic smooth muscle cells in vitro

Objective: The hypothesis to be tested was that diminished bioavailable nitric oxide (NO) affects matrix metalloproteinase (MMP) expression and activation in vascular smooth muscle cells (SMCs). Methods: Cultivated rat aortic SMCs (RA-SMCs) were exposed to increasing concentrations of L-N-monomethyl...

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Veröffentlicht in:	Journal of vascular surgery 2001-07, Vol.34 (1), p.76-83
Hauptverfasser:	Upchurch, Gilbert R., Ford, John W., Weiss, Steven J., Knipp, Brian S., Peterson, David A., Thompson, Robert W., Eagleton, Matthew J., Broady, Autumn J., Proctor, Mary C., Stanley, James C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Blotting, Western Cells, Cultured Electrophoresis, Polyacrylamide Gel Enzyme Inhibitors - pharmacology Male Matrix Metalloproteinase 9 - metabolism Muscle, Smooth, Vascular - cytology Nitric Oxide - physiology omega-N-Methylarginine - pharmacology Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism
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