Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss
Approximately one in 300 women experience recurrent pregnancy loss (RPL), the aetiology of which is unknown in at least 40% of cases. Previously, some studies have shown increased production of pro-inflammatory cytokines (tumour necrosis factor-α and interferon-γ) and reduced production of anti-infl...
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| Veröffentlicht in: | Journal of reproductive immunology 2001-07, Vol.51 (1), p.21-27 |
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| container_title | Journal of reproductive immunology |
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| creator | Babbage, Sarah J. Arkwright, Peter D. Vince, Gill S. Perrey, Chris Pravica, Vera Quenby, Siobhan Bates, Michelle Hutchinson, Ian V. |
| description | Approximately one in 300 women experience recurrent pregnancy loss (RPL), the aetiology of which is unknown in at least 40% of cases. Previously, some studies have shown increased production of pro-inflammatory cytokines (tumour necrosis factor-α and interferon-γ) and reduced production of anti-inflammatory cytokines (interleukin-10) by circulating blood lymphocytes isolated from these patients when compared with controls. The reasons for this are unclear. The production of these cytokines are partly under genetic control. This study investigated whether polymorphisms in these three cytokine genes known to be associated with either high or low production, are associated with idiopathic RPL. No association was found. It may be that genetic factors are not a major determinant of cytokine production during pregnancy, or alternatively it may be that the observed differences in cytokine production by peripheral lymphocytes do not accurately indicate what is occurring at the local maternofoetal interface during successful and abortive pregnancies. |
| doi_str_mv | 10.1016/S0165-0378(01)00069-9 |
| format | Article |
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Previously, some studies have shown increased production of pro-inflammatory cytokines (tumour necrosis factor-α and interferon-γ) and reduced production of anti-inflammatory cytokines (interleukin-10) by circulating blood lymphocytes isolated from these patients when compared with controls. The reasons for this are unclear. The production of these cytokines are partly under genetic control. This study investigated whether polymorphisms in these three cytokine genes known to be associated with either high or low production, are associated with idiopathic RPL. No association was found. It may be that genetic factors are not a major determinant of cytokine production during pregnancy, or alternatively it may be that the observed differences in cytokine production by peripheral lymphocytes do not accurately indicate what is occurring at the local maternofoetal interface during successful and abortive pregnancies.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/S0165-0378(01)00069-9</identifier><identifier>PMID: 11438378</identifier><identifier>CODEN: JRIMDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Abortion, Habitual - genetics ; Adult ; Biological and medical sciences ; Cytokine gene polymorphisms ; Cytokines - genetics ; Diseases of mother, fetus and pregnancy ; Female ; g-Interferon ; Genetic Predisposition to Disease ; Gynecology. Andrology. Obstetrics ; Humans ; Interferon-gamma - genetics ; Interferon-γ ; Interleukin-10 ; Interleukin-10 - genetics ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Pregnancy ; Pregnancy. Fetus. Placenta ; Promoter Regions, Genetic - genetics ; Recurrent pregnancy loss ; Tumor Necrosis Factor-alpha - genetics ; Tumour necrosis factor-α</subject><ispartof>Journal of reproductive immunology, 2001-07, Vol.51 (1), p.21-27</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-801faabaf8fb63e2dd8e97ec456245f7088bb4b1124a22bb362fd91e07c018a43</citedby><cites>FETCH-LOGICAL-c421t-801faabaf8fb63e2dd8e97ec456245f7088bb4b1124a22bb362fd91e07c018a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-0378(01)00069-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1074385$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11438378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babbage, Sarah J.</creatorcontrib><creatorcontrib>Arkwright, Peter D.</creatorcontrib><creatorcontrib>Vince, Gill S.</creatorcontrib><creatorcontrib>Perrey, Chris</creatorcontrib><creatorcontrib>Pravica, Vera</creatorcontrib><creatorcontrib>Quenby, Siobhan</creatorcontrib><creatorcontrib>Bates, Michelle</creatorcontrib><creatorcontrib>Hutchinson, Ian V.</creatorcontrib><title>Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Approximately one in 300 women experience recurrent pregnancy loss (RPL), the aetiology of which is unknown in at least 40% of cases. Previously, some studies have shown increased production of pro-inflammatory cytokines (tumour necrosis factor-α and interferon-γ) and reduced production of anti-inflammatory cytokines (interleukin-10) by circulating blood lymphocytes isolated from these patients when compared with controls. The reasons for this are unclear. The production of these cytokines are partly under genetic control. This study investigated whether polymorphisms in these three cytokine genes known to be associated with either high or low production, are associated with idiopathic RPL. No association was found. It may be that genetic factors are not a major determinant of cytokine production during pregnancy, or alternatively it may be that the observed differences in cytokine production by peripheral lymphocytes do not accurately indicate what is occurring at the local maternofoetal interface during successful and abortive pregnancies.</description><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cytokine gene polymorphisms</subject><subject>Cytokines - genetics</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>g-Interferon</subject><subject>Genetic Predisposition to Disease</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Interferon-gamma - genetics</subject><subject>Interferon-γ</subject><subject>Interleukin-10</subject><subject>Interleukin-10 - genetics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Recurrent pregnancy loss</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumour necrosis factor-α</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAURi1ExQxTfgIoC1TBInBv4sTOqqpGQCuN1AV0bTnODbgk8WBnkObf1_NQYTcbW7bOdx-HsXOEGwQsbx_jUaSQC3kFeA0AZZVWR2yKUmSpKCE_ZtP_yISdhvAXAAVUeMImiDyX8X_KFvP16F7tQMnSu96N5JNn2rxct-6dX77Y0IdED01iG-uWenyxJvFkVt7TMMYQPQ96MOukcyF8ZV9a3QU6298z9uf-7mn-M138fvg1_7FIDc9wTCVgq3WtW9nWZU5Z00iqBBlelBkvWgFS1jWvETOus6yu8zJrmwoJhAGUmucz9m1XN878tqIwqt4GQ12nB3KroOKWgvMKD4IoQQgoiggWO9D4uIenVi297bVfKwS18a22vtVGpgJUW9-qirmLfYNV3VPzkdoLjsDlHtDB6K71UZYNn6qLCG76f99hFLW9W_IqGEuDocZG2aNqnD0wyT8S_Z01</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Babbage, Sarah J.</creator><creator>Arkwright, Peter D.</creator><creator>Vince, Gill S.</creator><creator>Perrey, Chris</creator><creator>Pravica, Vera</creator><creator>Quenby, Siobhan</creator><creator>Bates, Michelle</creator><creator>Hutchinson, Ian V.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss</title><author>Babbage, Sarah J. ; Arkwright, Peter D. ; Vince, Gill S. ; Perrey, Chris ; Pravica, Vera ; Quenby, Siobhan ; Bates, Michelle ; Hutchinson, Ian V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-801faabaf8fb63e2dd8e97ec456245f7088bb4b1124a22bb362fd91e07c018a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Abortion, Habitual - genetics</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cytokine gene polymorphisms</topic><topic>Cytokines - genetics</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>g-Interferon</topic><topic>Genetic Predisposition to Disease</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Interferon-gamma - genetics</topic><topic>Interferon-γ</topic><topic>Interleukin-10</topic><topic>Interleukin-10 - genetics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Recurrent pregnancy loss</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumour necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babbage, Sarah J.</creatorcontrib><creatorcontrib>Arkwright, Peter D.</creatorcontrib><creatorcontrib>Vince, Gill S.</creatorcontrib><creatorcontrib>Perrey, Chris</creatorcontrib><creatorcontrib>Pravica, Vera</creatorcontrib><creatorcontrib>Quenby, Siobhan</creatorcontrib><creatorcontrib>Bates, Michelle</creatorcontrib><creatorcontrib>Hutchinson, Ian V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babbage, Sarah J.</au><au>Arkwright, Peter D.</au><au>Vince, Gill S.</au><au>Perrey, Chris</au><au>Pravica, Vera</au><au>Quenby, Siobhan</au><au>Bates, Michelle</au><au>Hutchinson, Ian V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>51</volume><issue>1</issue><spage>21</spage><epage>27</epage><pages>21-27</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><coden>JRIMDR</coden><abstract>Approximately one in 300 women experience recurrent pregnancy loss (RPL), the aetiology of which is unknown in at least 40% of cases. Previously, some studies have shown increased production of pro-inflammatory cytokines (tumour necrosis factor-α and interferon-γ) and reduced production of anti-inflammatory cytokines (interleukin-10) by circulating blood lymphocytes isolated from these patients when compared with controls. The reasons for this are unclear. The production of these cytokines are partly under genetic control. This study investigated whether polymorphisms in these three cytokine genes known to be associated with either high or low production, are associated with idiopathic RPL. No association was found. It may be that genetic factors are not a major determinant of cytokine production during pregnancy, or alternatively it may be that the observed differences in cytokine production by peripheral lymphocytes do not accurately indicate what is occurring at the local maternofoetal interface during successful and abortive pregnancies.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11438378</pmid><doi>10.1016/S0165-0378(01)00069-9</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Abortion, Habitual - genetics Adult Biological and medical sciences Cytokine gene polymorphisms Cytokines - genetics Diseases of mother, fetus and pregnancy Female g-Interferon Genetic Predisposition to Disease Gynecology. Andrology. Obstetrics Humans Interferon-gamma - genetics Interferon-γ Interleukin-10 Interleukin-10 - genetics Medical sciences Middle Aged Polymorphism, Genetic Pregnancy Pregnancy. Fetus. Placenta Promoter Regions, Genetic - genetics Recurrent pregnancy loss Tumor Necrosis Factor-alpha - genetics Tumour necrosis factor-α |
| title | Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss |
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