The Window of Opportunity for Neuronal Rescue With Insulin-Like Growth Factor-1 After Hypoxia-Ischemia in Rats Is Critically Modulated by Cerebral Temperature During Recovery

Insulin-like growth factor (IGF-1) is induced in damaged brain tissue after hypoxia—ischemia, and exogenous administration of IGF-1 shortly after injury has been shown to be neuroprotective. However, it is unknown whether treatment with IGF-1 delayed by more than a few hours after injury may be prot...

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