Abnormal cardiovascular reflex tests are predictors of mortality in Type 2 diabetes mellitus
SUMMARY Aims To determine whether diabetic autonomic neuropathy is an important factor contributing to mortality in Type 2 diabetes mellitus. Methods Between 1989 and 1993, 431 men and 181 women with Type 2 diabetes were given diabetic autonomic neuropathy cardiovascular reflex (CVR) tests. These...
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| Veröffentlicht in: | Diabetic medicine 2001-04, Vol.18 (4), p.268-273 |
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| creator | Chen, H. S. Hwu, C. M. Kuo, B. I. Chiang, S. C. Kwok, C. F. Lee, S. H. Lee, Y. S. Weih, M. J. Hsiao, L. C. Lin, S. H. Ho, L. T. |
| description | SUMMARY
Aims To determine whether diabetic autonomic neuropathy is an important factor contributing to mortality in Type 2 diabetes mellitus.
Methods Between 1989 and 1993, 431 men and 181 women with Type 2 diabetes were given diabetic autonomic neuropathy cardiovascular reflex (CVR) tests. These subjects were followed for the subsequent 5–9 years to assess mortality rates.
Results The prevalence rate of abnormal CVR tests was 46.1% in patients with the history of diabetes less than 5 years and up to 69.4% when the history of diabetes exceeded 20 years. During the follow‐up period from 1 January 1989 to 31 December 1997 (mean 7.7 years), a total of 135 participants died. The 8‐year survival rate for patients with abnormal CVR tests was 63.6% in males and 76.4% in females, compared with 80.9 and 93.3% for patients with normal CVR tests. The results were grouped as: group 1, normal CVR tests without postural hypotension (PHT); group 2, normal CVR tests with PHT; group 3, abnormal CVR tests without PHT; and group 4, abnormal CVR tests with PHT. The 8‐year survival rate was 85.4% in group 1, 80.9% in group 2, 74.5% in group 3 and 61.1% in group 4.
Conclusion Type 2 diabetic patients with abnormal CVR tests may have increased mortality, and those combined with postural hypotension have higher mortality than those without. Abnormal CVR tests may be important predictors of mortality in Type 2 diabetes mellitus. |
| doi_str_mv | 10.1046/j.1464-5491.2001.00442.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70973403</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70973403</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4972-3dd6b508039a7c0499af24ba2e23c6c67c4fbf1585990b5435e8d610a8f179e3</originalsourceid><addsrcrecordid>eNqNkF1r2zAUhkXpaNOuf2HoovTOnmR9WdCbfqaDdB8QWC8G4liWQakdp5K9Jf--yhLaXe5KgvO8Oq8ehDAlOSVcfl7klEueCa5pXhBCc0I4L_L1AZq8DQ7RhCheZIwoeoxOYlwksNBMH6FjSjlTpZAT9OuqWvahgxZbCLXvf0O0YwsBB9e0bo0HF4eIITi8Cq72duhDxH2Duz4M0Pphg_0Szzcrhwtce6hcCuDOtWk0xo_oQwNtdGf78xTN7-_mNw_Z7Nv0y83VLLNcq9SwrmUlSEmYBmUJ1xqagldQuIJZaaWyvKkaKkqhNakEZ8KVtaQEyoYq7dgputg9uwr9y5gKm85HmzrA0vVjNIpoxThhCSx3oA19jOmHZhV8B2FjKDFbsWZhtv7M1p_ZijV_xZp1in7a7xirztXvwb3JBJzvgWQQ2ibA0vr4zwIphOYJu9xhf3zrNv-939w-3qVLime7uI-DW7_FITwbqZgS5ufXqfk-lT8er2dP5pq9AkZaovo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70973403</pqid></control><display><type>article</type><title>Abnormal cardiovascular reflex tests are predictors of mortality in Type 2 diabetes mellitus</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Chen, H. S. ; Hwu, C. M. ; Kuo, B. I. ; Chiang, S. C. ; Kwok, C. F. ; Lee, S. H. ; Lee, Y. S. ; Weih, M. J. ; Hsiao, L. C. ; Lin, S. H. ; Ho, L. T.</creator><creatorcontrib>Chen, H. S. ; Hwu, C. M. ; Kuo, B. I. ; Chiang, S. C. ; Kwok, C. F. ; Lee, S. H. ; Lee, Y. S. ; Weih, M. J. ; Hsiao, L. C. ; Lin, S. H. ; Ho, L. T.</creatorcontrib><description>SUMMARY
Aims To determine whether diabetic autonomic neuropathy is an important factor contributing to mortality in Type 2 diabetes mellitus.
Methods Between 1989 and 1993, 431 men and 181 women with Type 2 diabetes were given diabetic autonomic neuropathy cardiovascular reflex (CVR) tests. These subjects were followed for the subsequent 5–9 years to assess mortality rates.
Results The prevalence rate of abnormal CVR tests was 46.1% in patients with the history of diabetes less than 5 years and up to 69.4% when the history of diabetes exceeded 20 years. During the follow‐up period from 1 January 1989 to 31 December 1997 (mean 7.7 years), a total of 135 participants died. The 8‐year survival rate for patients with abnormal CVR tests was 63.6% in males and 76.4% in females, compared with 80.9 and 93.3% for patients with normal CVR tests. The results were grouped as: group 1, normal CVR tests without postural hypotension (PHT); group 2, normal CVR tests with PHT; group 3, abnormal CVR tests without PHT; and group 4, abnormal CVR tests with PHT. The 8‐year survival rate was 85.4% in group 1, 80.9% in group 2, 74.5% in group 3 and 61.1% in group 4.
Conclusion Type 2 diabetic patients with abnormal CVR tests may have increased mortality, and those combined with postural hypotension have higher mortality than those without. Abnormal CVR tests may be important predictors of mortality in Type 2 diabetes mellitus.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1046/j.1464-5491.2001.00442.x</identifier><identifier>PMID: 11437856</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; autonomic neuropathy ; Biological and medical sciences ; Blood Pressure - physiology ; cardiovascular reflex tests ; Cause of Death ; Diabetes Mellitus, Type 2 - mortality ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Neuropathies - mortality ; Diabetic Neuropathies - physiopathology ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Follow-Up Studies ; Heart Rate - physiology ; Humans ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; mortality ; postural hypotension ; Posture ; Predictive Value of Tests ; Proportional Hazards Models ; Reflex ; Respiratory Mechanics ; Survival Rate ; Taiwan ; Type 2 diabetes</subject><ispartof>Diabetic medicine, 2001-04, Vol.18 (4), p.268-273</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4972-3dd6b508039a7c0499af24ba2e23c6c67c4fbf1585990b5435e8d610a8f179e3</citedby><cites>FETCH-LOGICAL-c4972-3dd6b508039a7c0499af24ba2e23c6c67c4fbf1585990b5435e8d610a8f179e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1464-5491.2001.00442.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1464-5491.2001.00442.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1065594$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11437856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, H. S.</creatorcontrib><creatorcontrib>Hwu, C. M.</creatorcontrib><creatorcontrib>Kuo, B. I.</creatorcontrib><creatorcontrib>Chiang, S. C.</creatorcontrib><creatorcontrib>Kwok, C. F.</creatorcontrib><creatorcontrib>Lee, S. H.</creatorcontrib><creatorcontrib>Lee, Y. S.</creatorcontrib><creatorcontrib>Weih, M. J.</creatorcontrib><creatorcontrib>Hsiao, L. C.</creatorcontrib><creatorcontrib>Lin, S. H.</creatorcontrib><creatorcontrib>Ho, L. T.</creatorcontrib><title>Abnormal cardiovascular reflex tests are predictors of mortality in Type 2 diabetes mellitus</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>SUMMARY
Aims To determine whether diabetic autonomic neuropathy is an important factor contributing to mortality in Type 2 diabetes mellitus.
Methods Between 1989 and 1993, 431 men and 181 women with Type 2 diabetes were given diabetic autonomic neuropathy cardiovascular reflex (CVR) tests. These subjects were followed for the subsequent 5–9 years to assess mortality rates.
Results The prevalence rate of abnormal CVR tests was 46.1% in patients with the history of diabetes less than 5 years and up to 69.4% when the history of diabetes exceeded 20 years. During the follow‐up period from 1 January 1989 to 31 December 1997 (mean 7.7 years), a total of 135 participants died. The 8‐year survival rate for patients with abnormal CVR tests was 63.6% in males and 76.4% in females, compared with 80.9 and 93.3% for patients with normal CVR tests. The results were grouped as: group 1, normal CVR tests without postural hypotension (PHT); group 2, normal CVR tests with PHT; group 3, abnormal CVR tests without PHT; and group 4, abnormal CVR tests with PHT. The 8‐year survival rate was 85.4% in group 1, 80.9% in group 2, 74.5% in group 3 and 61.1% in group 4.
Conclusion Type 2 diabetic patients with abnormal CVR tests may have increased mortality, and those combined with postural hypotension have higher mortality than those without. Abnormal CVR tests may be important predictors of mortality in Type 2 diabetes mellitus.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>autonomic neuropathy</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - physiology</subject><subject>cardiovascular reflex tests</subject><subject>Cause of Death</subject><subject>Diabetes Mellitus, Type 2 - mortality</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Neuropathies - mortality</subject><subject>Diabetic Neuropathies - physiopathology</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>postural hypotension</subject><subject>Posture</subject><subject>Predictive Value of Tests</subject><subject>Proportional Hazards Models</subject><subject>Reflex</subject><subject>Respiratory Mechanics</subject><subject>Survival Rate</subject><subject>Taiwan</subject><subject>Type 2 diabetes</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1r2zAUhkXpaNOuf2HoovTOnmR9WdCbfqaDdB8QWC8G4liWQakdp5K9Jf--yhLaXe5KgvO8Oq8ehDAlOSVcfl7klEueCa5pXhBCc0I4L_L1AZq8DQ7RhCheZIwoeoxOYlwksNBMH6FjSjlTpZAT9OuqWvahgxZbCLXvf0O0YwsBB9e0bo0HF4eIITi8Cq72duhDxH2Duz4M0Pphg_0Szzcrhwtce6hcCuDOtWk0xo_oQwNtdGf78xTN7-_mNw_Z7Nv0y83VLLNcq9SwrmUlSEmYBmUJ1xqagldQuIJZaaWyvKkaKkqhNakEZ8KVtaQEyoYq7dgputg9uwr9y5gKm85HmzrA0vVjNIpoxThhCSx3oA19jOmHZhV8B2FjKDFbsWZhtv7M1p_ZijV_xZp1in7a7xirztXvwb3JBJzvgWQQ2ibA0vr4zwIphOYJu9xhf3zrNv-939w-3qVLime7uI-DW7_FITwbqZgS5ufXqfk-lT8er2dP5pq9AkZaovo</recordid><startdate>200104</startdate><enddate>200104</enddate><creator>Chen, H. S.</creator><creator>Hwu, C. M.</creator><creator>Kuo, B. I.</creator><creator>Chiang, S. C.</creator><creator>Kwok, C. F.</creator><creator>Lee, S. H.</creator><creator>Lee, Y. S.</creator><creator>Weih, M. J.</creator><creator>Hsiao, L. C.</creator><creator>Lin, S. H.</creator><creator>Ho, L. T.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200104</creationdate><title>Abnormal cardiovascular reflex tests are predictors of mortality in Type 2 diabetes mellitus</title><author>Chen, H. S. ; Hwu, C. M. ; Kuo, B. I. ; Chiang, S. C. ; Kwok, C. F. ; Lee, S. H. ; Lee, Y. S. ; Weih, M. J. ; Hsiao, L. C. ; Lin, S. H. ; Ho, L. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4972-3dd6b508039a7c0499af24ba2e23c6c67c4fbf1585990b5435e8d610a8f179e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>autonomic neuropathy</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - physiology</topic><topic>cardiovascular reflex tests</topic><topic>Cause of Death</topic><topic>Diabetes Mellitus, Type 2 - mortality</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Neuropathies - mortality</topic><topic>Diabetic Neuropathies - physiopathology</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>postural hypotension</topic><topic>Posture</topic><topic>Predictive Value of Tests</topic><topic>Proportional Hazards Models</topic><topic>Reflex</topic><topic>Respiratory Mechanics</topic><topic>Survival Rate</topic><topic>Taiwan</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, H. S.</creatorcontrib><creatorcontrib>Hwu, C. M.</creatorcontrib><creatorcontrib>Kuo, B. I.</creatorcontrib><creatorcontrib>Chiang, S. C.</creatorcontrib><creatorcontrib>Kwok, C. F.</creatorcontrib><creatorcontrib>Lee, S. H.</creatorcontrib><creatorcontrib>Lee, Y. S.</creatorcontrib><creatorcontrib>Weih, M. J.</creatorcontrib><creatorcontrib>Hsiao, L. C.</creatorcontrib><creatorcontrib>Lin, S. H.</creatorcontrib><creatorcontrib>Ho, L. T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, H. S.</au><au>Hwu, C. M.</au><au>Kuo, B. I.</au><au>Chiang, S. C.</au><au>Kwok, C. F.</au><au>Lee, S. H.</au><au>Lee, Y. S.</au><au>Weih, M. J.</au><au>Hsiao, L. C.</au><au>Lin, S. H.</au><au>Ho, L. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal cardiovascular reflex tests are predictors of mortality in Type 2 diabetes mellitus</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2001-04</date><risdate>2001</risdate><volume>18</volume><issue>4</issue><spage>268</spage><epage>273</epage><pages>268-273</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>SUMMARY
Aims To determine whether diabetic autonomic neuropathy is an important factor contributing to mortality in Type 2 diabetes mellitus.
Methods Between 1989 and 1993, 431 men and 181 women with Type 2 diabetes were given diabetic autonomic neuropathy cardiovascular reflex (CVR) tests. These subjects were followed for the subsequent 5–9 years to assess mortality rates.
Results The prevalence rate of abnormal CVR tests was 46.1% in patients with the history of diabetes less than 5 years and up to 69.4% when the history of diabetes exceeded 20 years. During the follow‐up period from 1 January 1989 to 31 December 1997 (mean 7.7 years), a total of 135 participants died. The 8‐year survival rate for patients with abnormal CVR tests was 63.6% in males and 76.4% in females, compared with 80.9 and 93.3% for patients with normal CVR tests. The results were grouped as: group 1, normal CVR tests without postural hypotension (PHT); group 2, normal CVR tests with PHT; group 3, abnormal CVR tests without PHT; and group 4, abnormal CVR tests with PHT. The 8‐year survival rate was 85.4% in group 1, 80.9% in group 2, 74.5% in group 3 and 61.1% in group 4.
Conclusion Type 2 diabetic patients with abnormal CVR tests may have increased mortality, and those combined with postural hypotension have higher mortality than those without. Abnormal CVR tests may be important predictors of mortality in Type 2 diabetes mellitus.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11437856</pmid><doi>10.1046/j.1464-5491.2001.00442.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy autonomic neuropathy Biological and medical sciences Blood Pressure - physiology cardiovascular reflex tests Cause of Death Diabetes Mellitus, Type 2 - mortality Diabetes Mellitus, Type 2 - physiopathology Diabetic Neuropathies - mortality Diabetic Neuropathies - physiopathology Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Follow-Up Studies Heart Rate - physiology Humans Intensive care medicine Male Medical sciences Middle Aged mortality postural hypotension Posture Predictive Value of Tests Proportional Hazards Models Reflex Respiratory Mechanics Survival Rate Taiwan Type 2 diabetes |
| title | Abnormal cardiovascular reflex tests are predictors of mortality in Type 2 diabetes mellitus |
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