Diclofenac Treatment Prolongs Renal Transit Time in Acute Ureteral Obstruction: A Renographic Study
Objective: Prostaglandin inhibitors, mostly diclofenac, are currently first–choice therapy for ureteral colic, their main action being reduction of intrapelvic pressure and diuresis. We hypothesized that diclofenac, by increasing tubular reabsorption, can delay excretion of contrast medium and give...
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| Veröffentlicht in: | European urology 2000-03, Vol.37 (3), p.334-338 |
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| creator | Kinn, Anne-Charlotte Larsson, Stig A. Nelson, Elisabeth Jacobsson, Hans |
| description | Objective: Prostaglandin inhibitors, mostly diclofenac, are currently first–choice therapy for ureteral colic, their main action being reduction of intrapelvic pressure and diuresis. We hypothesized that diclofenac, by increasing tubular reabsorption, can delay excretion of contrast medium and give a false impression of severe obstruction. Methods: Gamma camera renography was performed with 50 MBq 99 Tc m –MAG3 before and with 150 MBq 30 min after intramuscular injection of 75 mg diclofenac in 10 patients with acute ureteral colic. The time to maximum isotope activity in each kidney, T max , was compared with T max in 10 control patients, who did not receive diclofenac but underwent two identical renographies. Results: T max was significantly delayed after diclofenac, from 353 s at baseline to >1,200 s on the stone side, and from 225 to 465 s on the healthy side. Without diclofenac there was no T max retardation between the two renographies. Conclusion: Diclofenac treatment can lead to overestimation in ureteral stone disease, by delaying renal excretion bilaterally, but predominantly on the side of calculus. |
| doi_str_mv | 10.1159/000052366 |
| format | Article |
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We hypothesized that diclofenac, by increasing tubular reabsorption, can delay excretion of contrast medium and give a false impression of severe obstruction. Methods: Gamma camera renography was performed with 50 MBq 99 Tc m –MAG3 before and with 150 MBq 30 min after intramuscular injection of 75 mg diclofenac in 10 patients with acute ureteral colic. The time to maximum isotope activity in each kidney, T max , was compared with T max in 10 control patients, who did not receive diclofenac but underwent two identical renographies. Results: T max was significantly delayed after diclofenac, from 353 s at baseline to >1,200 s on the stone side, and from 225 to 465 s on the healthy side. Without diclofenac there was no T max retardation between the two renographies. Conclusion: Diclofenac treatment can lead to overestimation in ureteral stone disease, by delaying renal excretion bilaterally, but predominantly on the side of calculus.</description><identifier>ISSN: 0302-2838</identifier><identifier>EISSN: 1873-7560</identifier><identifier>EISSN: 1421-993X</identifier><identifier>DOI: 10.1159/000052366</identifier><identifier>PMID: 10720862</identifier><identifier>CODEN: EUURAV</identifier><language>eng</language><publisher>Basel, Switzerland: Elsevier</publisher><subject>Acute Disease ; Biological and medical sciences ; Colic - diagnostic imaging ; Colic - drug therapy ; Cyclooxygenase Inhibitors - therapeutic use ; Diclofenac - therapeutic use ; Humans ; Kidney - drug effects ; Kidney - physiopathology ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Nephrology. Urinary tract diseases ; Radioisotope Renography ; Radiopharmaceuticals ; Stones ; Technetium Tc 99m Mertiatide ; Time Factors ; Ureteral Calculi - diagnostic imaging ; Ureteral Calculi - drug therapy ; Ureteral Obstruction - diagnostic imaging ; Ureteral Obstruction - drug therapy ; Urinary lithiasis</subject><ispartof>European urology, 2000-03, Vol.37 (3), p.334-338</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-970b16be388f108795247c3969bf2ce506397bb1984084648bf380f78c952fc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2427,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1315084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10720862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1941714$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinn, Anne-Charlotte</creatorcontrib><creatorcontrib>Larsson, Stig A.</creatorcontrib><creatorcontrib>Nelson, Elisabeth</creatorcontrib><creatorcontrib>Jacobsson, Hans</creatorcontrib><title>Diclofenac Treatment Prolongs Renal Transit Time in Acute Ureteral Obstruction: A Renographic Study</title><title>European urology</title><addtitle>Eur Urol</addtitle><description>Objective: Prostaglandin inhibitors, mostly diclofenac, are currently first–choice therapy for ureteral colic, their main action being reduction of intrapelvic pressure and diuresis. We hypothesized that diclofenac, by increasing tubular reabsorption, can delay excretion of contrast medium and give a false impression of severe obstruction. Methods: Gamma camera renography was performed with 50 MBq 99 Tc m –MAG3 before and with 150 MBq 30 min after intramuscular injection of 75 mg diclofenac in 10 patients with acute ureteral colic. The time to maximum isotope activity in each kidney, T max , was compared with T max in 10 control patients, who did not receive diclofenac but underwent two identical renographies. Results: T max was significantly delayed after diclofenac, from 353 s at baseline to >1,200 s on the stone side, and from 225 to 465 s on the healthy side. Without diclofenac there was no T max retardation between the two renographies. Conclusion: Diclofenac treatment can lead to overestimation in ureteral stone disease, by delaying renal excretion bilaterally, but predominantly on the side of calculus.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>Colic - diagnostic imaging</subject><subject>Colic - drug therapy</subject><subject>Cyclooxygenase Inhibitors - therapeutic use</subject><subject>Diclofenac - therapeutic use</subject><subject>Humans</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Radioisotope Renography</subject><subject>Radiopharmaceuticals</subject><subject>Stones</subject><subject>Technetium Tc 99m Mertiatide</subject><subject>Time Factors</subject><subject>Ureteral Calculi - diagnostic imaging</subject><subject>Ureteral Calculi - drug therapy</subject><subject>Ureteral Obstruction - diagnostic imaging</subject><subject>Ureteral Obstruction - drug therapy</subject><subject>Urinary lithiasis</subject><issn>0302-2838</issn><issn>1873-7560</issn><issn>1421-993X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1vFCEYB2BiNHatHjybGGKMiYdRvoYPb5u2fiRNaur2TBgWVuzMMAIT0_--1Fm3HpQLhPf5AeEF4DlG7zBu1XtUR0so5w_ACktBG9Fy9BCsEEWkIZLKI_Ak5x9V0VbRx-AII0GQ5GQF7GmwffRuNBZukjNlcGOBX1Ps47jL8LIW-lowYw4FbsLgYBjh2s7Fwavkiku1fNHlkmZbQhw_wPVdJu6Smb4HC7-VeXvzFDzyps_u2X4-BpuPZ5uTz835xacvJ-vzxjJGS6ME6jDvHJXSYySFagkTliquOk-saxGnSnQdVpIhyTiTnacSeSFtld7SY9Asx-Zfbpo7PaUwmHSjowl6v3VdV05zRBhpqxf_9VOK2_vQnyBWDAvMavLNkqzs5-xy0UPI1vW9GV2csxZIifp2XuHbBdoUc07OHy7BSN-1Th9aV-3L_aFzN7jtX3LpVQWv98Bka3pfm2JDvncUt_VfKnu1sGuTdi4d6mdXl78v0tPWV_Tin2h5yi0V4bUy</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Kinn, Anne-Charlotte</creator><creator>Larsson, Stig A.</creator><creator>Nelson, Elisabeth</creator><creator>Jacobsson, Hans</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20000301</creationdate><title>Diclofenac Treatment Prolongs Renal Transit Time in Acute Ureteral Obstruction: A Renographic Study</title><author>Kinn, Anne-Charlotte ; Larsson, Stig A. ; Nelson, Elisabeth ; Jacobsson, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-970b16be388f108795247c3969bf2ce506397bb1984084648bf380f78c952fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>Colic - diagnostic imaging</topic><topic>Colic - drug therapy</topic><topic>Cyclooxygenase Inhibitors - therapeutic use</topic><topic>Diclofenac - therapeutic use</topic><topic>Humans</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Radioisotope Renography</topic><topic>Radiopharmaceuticals</topic><topic>Stones</topic><topic>Technetium Tc 99m Mertiatide</topic><topic>Time Factors</topic><topic>Ureteral Calculi - diagnostic imaging</topic><topic>Ureteral Calculi - drug therapy</topic><topic>Ureteral Obstruction - diagnostic imaging</topic><topic>Ureteral Obstruction - drug therapy</topic><topic>Urinary lithiasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinn, Anne-Charlotte</creatorcontrib><creatorcontrib>Larsson, Stig A.</creatorcontrib><creatorcontrib>Nelson, Elisabeth</creatorcontrib><creatorcontrib>Jacobsson, Hans</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>European urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinn, Anne-Charlotte</au><au>Larsson, Stig A.</au><au>Nelson, Elisabeth</au><au>Jacobsson, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diclofenac Treatment Prolongs Renal Transit Time in Acute Ureteral Obstruction: A Renographic Study</atitle><jtitle>European urology</jtitle><addtitle>Eur Urol</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>37</volume><issue>3</issue><spage>334</spage><epage>338</epage><pages>334-338</pages><issn>0302-2838</issn><eissn>1873-7560</eissn><eissn>1421-993X</eissn><coden>EUURAV</coden><abstract>Objective: Prostaglandin inhibitors, mostly diclofenac, are currently first–choice therapy for ureteral colic, their main action being reduction of intrapelvic pressure and diuresis. We hypothesized that diclofenac, by increasing tubular reabsorption, can delay excretion of contrast medium and give a false impression of severe obstruction. Methods: Gamma camera renography was performed with 50 MBq 99 Tc m –MAG3 before and with 150 MBq 30 min after intramuscular injection of 75 mg diclofenac in 10 patients with acute ureteral colic. The time to maximum isotope activity in each kidney, T max , was compared with T max in 10 control patients, who did not receive diclofenac but underwent two identical renographies. Results: T max was significantly delayed after diclofenac, from 353 s at baseline to >1,200 s on the stone side, and from 225 to 465 s on the healthy side. Without diclofenac there was no T max retardation between the two renographies. Conclusion: Diclofenac treatment can lead to overestimation in ureteral stone disease, by delaying renal excretion bilaterally, but predominantly on the side of calculus.</abstract><cop>Basel, Switzerland</cop><pub>Elsevier</pub><pmid>10720862</pmid><doi>10.1159/000052366</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute Disease Biological and medical sciences Colic - diagnostic imaging Colic - drug therapy Cyclooxygenase Inhibitors - therapeutic use Diclofenac - therapeutic use Humans Kidney - drug effects Kidney - physiopathology Male Medical sciences Medicin och hälsovetenskap Middle Aged Nephrology. Urinary tract diseases Radioisotope Renography Radiopharmaceuticals Stones Technetium Tc 99m Mertiatide Time Factors Ureteral Calculi - diagnostic imaging Ureteral Calculi - drug therapy Ureteral Obstruction - diagnostic imaging Ureteral Obstruction - drug therapy Urinary lithiasis |
| title | Diclofenac Treatment Prolongs Renal Transit Time in Acute Ureteral Obstruction: A Renographic Study |
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