Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder
Background: N-acetyl aspartate (NAA) is an amino acid present in high concentrations in neurons and is thus a putative neuronal marker. In vivo proton magnetic resonance spectroscopy ( 1H MRS) studies have shown lower NAA concentrations in patients with various neurodegenerative disorders, suggestin...
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| Veröffentlicht in: | Biological psychiatry (1969) 2000-03, Vol.47 (6), p.475-481 |
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| container_title | Biological psychiatry (1969) |
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| creator | Winsberg, Mirène E Sachs, Nadia Tate, Debbie L Adalsteinsson, Elfar Spielman, Daniel Ketter, Terence A |
| description | Background:
N-acetyl aspartate (NAA) is an amino acid present in high concentrations in neurons and is thus a putative neuronal marker. In vivo proton magnetic resonance spectroscopy (
1H MRS) studies have shown lower NAA concentrations in patients with various neurodegenerative disorders, suggesting decreased neuronal number, size, or function. Dorsolateral prefrontal (DLPF) NAA has not been extensively assessed in bipolar disorder patients, but it could be decreased in view of consistent reports of decreased DLPF cerebral blood flow and metabolism in mood disorders. We measured DLPF NAA in patients with bipolar disorder and healthy control subjects using in vivo
1H MRS.
Methods: We obtained ratios of NAA, choline, and myoinositol (mI) to creatine-phosphocreatine (Cr-PCr) in bilateral DLPF 8-mL voxels of 20 bipolar patients (10 Bipolar I, 10 Bipolar II) and 20 age- and gender-matched healthy control subjects using
1H MRS.
Results: DLPF NAA/Cr-PCr ratios were lower on the right hemisphere(
p < .03) and the left hemisphere (
p < .003) in bipolar disorder patients compared with healthy control subjects.
Conclusions: These preliminary data suggest that bipolar disorder patients have decreased DLPF NAA/Cr-PCr. This finding could represent decreased neuronal density or neuronal dysfunction in the DLPF region. |
| doi_str_mv | 10.1016/S0006-3223(99)00183-3 |
| format | Article |
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N-acetyl aspartate (NAA) is an amino acid present in high concentrations in neurons and is thus a putative neuronal marker. In vivo proton magnetic resonance spectroscopy (
1H MRS) studies have shown lower NAA concentrations in patients with various neurodegenerative disorders, suggesting decreased neuronal number, size, or function. Dorsolateral prefrontal (DLPF) NAA has not been extensively assessed in bipolar disorder patients, but it could be decreased in view of consistent reports of decreased DLPF cerebral blood flow and metabolism in mood disorders. We measured DLPF NAA in patients with bipolar disorder and healthy control subjects using in vivo
1H MRS.
Methods: We obtained ratios of NAA, choline, and myoinositol (mI) to creatine-phosphocreatine (Cr-PCr) in bilateral DLPF 8-mL voxels of 20 bipolar patients (10 Bipolar I, 10 Bipolar II) and 20 age- and gender-matched healthy control subjects using
1H MRS.
Results: DLPF NAA/Cr-PCr ratios were lower on the right hemisphere(
p < .03) and the left hemisphere (
p < .003) in bipolar disorder patients compared with healthy control subjects.
Conclusions: These preliminary data suggest that bipolar disorder patients have decreased DLPF NAA/Cr-PCr. This finding could represent decreased neuronal density or neuronal dysfunction in the DLPF region.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(99)00183-3</identifier><identifier>PMID: 10715353</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>1H MRS ; Adult ; Adult and adolescent clinical studies ; Aspartic Acid - metabolism ; Biological and medical sciences ; bipolar disorder ; Bipolar Disorder - metabolism ; Bipolar disorders ; dorsolateral prefrontal region ; Female ; Functional Laterality - physiology ; Humans ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Mood disorders ; N-acetyl aspartate ; Prefrontal Cortex - anatomy & histology ; Prefrontal Cortex - metabolism ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Biological psychiatry (1969), 2000-03, Vol.47 (6), p.475-481</ispartof><rights>2000 Society of Biological Psychiatry</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-fa29b4d25e5f0dfeee1a3f0f3abceb356e01fb69ae1ec12700cc553a015e2c2d3</citedby><cites>FETCH-LOGICAL-c456t-fa29b4d25e5f0dfeee1a3f0f3abceb356e01fb69ae1ec12700cc553a015e2c2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322399001833$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1316554$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10715353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winsberg, Mirène E</creatorcontrib><creatorcontrib>Sachs, Nadia</creatorcontrib><creatorcontrib>Tate, Debbie L</creatorcontrib><creatorcontrib>Adalsteinsson, Elfar</creatorcontrib><creatorcontrib>Spielman, Daniel</creatorcontrib><creatorcontrib>Ketter, Terence A</creatorcontrib><title>Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background:
N-acetyl aspartate (NAA) is an amino acid present in high concentrations in neurons and is thus a putative neuronal marker. In vivo proton magnetic resonance spectroscopy (
1H MRS) studies have shown lower NAA concentrations in patients with various neurodegenerative disorders, suggesting decreased neuronal number, size, or function. Dorsolateral prefrontal (DLPF) NAA has not been extensively assessed in bipolar disorder patients, but it could be decreased in view of consistent reports of decreased DLPF cerebral blood flow and metabolism in mood disorders. We measured DLPF NAA in patients with bipolar disorder and healthy control subjects using in vivo
1H MRS.
Methods: We obtained ratios of NAA, choline, and myoinositol (mI) to creatine-phosphocreatine (Cr-PCr) in bilateral DLPF 8-mL voxels of 20 bipolar patients (10 Bipolar I, 10 Bipolar II) and 20 age- and gender-matched healthy control subjects using
1H MRS.
Results: DLPF NAA/Cr-PCr ratios were lower on the right hemisphere(
p < .03) and the left hemisphere (
p < .003) in bipolar disorder patients compared with healthy control subjects.
Conclusions: These preliminary data suggest that bipolar disorder patients have decreased DLPF NAA/Cr-PCr. This finding could represent decreased neuronal density or neuronal dysfunction in the DLPF region.</description><subject>1H MRS</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>bipolar disorder</subject><subject>Bipolar Disorder - metabolism</subject><subject>Bipolar disorders</subject><subject>dorsolateral prefrontal region</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>N-acetyl aspartate</subject><subject>Prefrontal Cortex - anatomy & histology</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7rr6E5QeRPRQnSSb1p5E1ieIHtRzmCYTiHTbmnSF_fdGd1FvnmYGvnl9jO1zOOXAi7NnAChyKYQ8rqoTAH4uc7nBxvy8lLmYgthk4x9kxHZifEtlKQTfZiMOJVdSyTG7uyITCCPZzHYhdg0OFLDJ-kAudO2Q0sccDQ3LJsPYYxgSkPk2q32f4JBZH7tgKeyyLYdNpL11nLDXm-uX2V3-8HR7P7t8yM1UFUPuUFT11ApFyoF1RMRROnASa0O1VAUBd3VRIXEyXJQAxiglEbgiYYSVE3a0mtuH7n1BcdBzHw01DbbULaIuoUpPlmUC1Qo0oYsxvaP74OcYlpqD_lKovxXqLz-6qvS3Qi1T38F6waKek_3TtXKWgMM1gNFg4wK2xsdfTvJCqWnCLlYYJRsfnoKOxlNryPpAZtC28_9c8glRQo57</recordid><startdate>20000315</startdate><enddate>20000315</enddate><creator>Winsberg, Mirène E</creator><creator>Sachs, Nadia</creator><creator>Tate, Debbie L</creator><creator>Adalsteinsson, Elfar</creator><creator>Spielman, Daniel</creator><creator>Ketter, Terence A</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000315</creationdate><title>Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder</title><author>Winsberg, Mirène E ; Sachs, Nadia ; Tate, Debbie L ; Adalsteinsson, Elfar ; Spielman, Daniel ; Ketter, Terence A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-fa29b4d25e5f0dfeee1a3f0f3abceb356e01fb69ae1ec12700cc553a015e2c2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>1H MRS</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>bipolar disorder</topic><topic>Bipolar Disorder - metabolism</topic><topic>Bipolar disorders</topic><topic>dorsolateral prefrontal region</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>N-acetyl aspartate</topic><topic>Prefrontal Cortex - anatomy & histology</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winsberg, Mirène E</creatorcontrib><creatorcontrib>Sachs, Nadia</creatorcontrib><creatorcontrib>Tate, Debbie L</creatorcontrib><creatorcontrib>Adalsteinsson, Elfar</creatorcontrib><creatorcontrib>Spielman, Daniel</creatorcontrib><creatorcontrib>Ketter, Terence A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winsberg, Mirène E</au><au>Sachs, Nadia</au><au>Tate, Debbie L</au><au>Adalsteinsson, Elfar</au><au>Spielman, Daniel</au><au>Ketter, Terence A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2000-03-15</date><risdate>2000</risdate><volume>47</volume><issue>6</issue><spage>475</spage><epage>481</epage><pages>475-481</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background:
N-acetyl aspartate (NAA) is an amino acid present in high concentrations in neurons and is thus a putative neuronal marker. In vivo proton magnetic resonance spectroscopy (
1H MRS) studies have shown lower NAA concentrations in patients with various neurodegenerative disorders, suggesting decreased neuronal number, size, or function. Dorsolateral prefrontal (DLPF) NAA has not been extensively assessed in bipolar disorder patients, but it could be decreased in view of consistent reports of decreased DLPF cerebral blood flow and metabolism in mood disorders. We measured DLPF NAA in patients with bipolar disorder and healthy control subjects using in vivo
1H MRS.
Methods: We obtained ratios of NAA, choline, and myoinositol (mI) to creatine-phosphocreatine (Cr-PCr) in bilateral DLPF 8-mL voxels of 20 bipolar patients (10 Bipolar I, 10 Bipolar II) and 20 age- and gender-matched healthy control subjects using
1H MRS.
Results: DLPF NAA/Cr-PCr ratios were lower on the right hemisphere(
p < .03) and the left hemisphere (
p < .003) in bipolar disorder patients compared with healthy control subjects.
Conclusions: These preliminary data suggest that bipolar disorder patients have decreased DLPF NAA/Cr-PCr. This finding could represent decreased neuronal density or neuronal dysfunction in the DLPF region.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10715353</pmid><doi>10.1016/S0006-3223(99)00183-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biological psychiatry (1969), 2000-03, Vol.47 (6), p.475-481 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 1H MRS Adult Adult and adolescent clinical studies Aspartic Acid - metabolism Biological and medical sciences bipolar disorder Bipolar Disorder - metabolism Bipolar disorders dorsolateral prefrontal region Female Functional Laterality - physiology Humans Magnetic Resonance Spectroscopy - methods Male Medical sciences Mood disorders N-acetyl aspartate Prefrontal Cortex - anatomy & histology Prefrontal Cortex - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder |
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