Breast Cancer after Prophylactic Bilateral Mastectomy in Women with a BRCA1 or BRCA2 Mutation

This investigation strengthens the case for mastectomy in women with a mutation of the BRCA1 or BRCA2 gene. The identification of the breast-cancer–susceptibility genes BRCA1 1 and BRCA2 2 evoked widespread interest in genetic testing among women at risk for a mutation in these genes. 3 , 4 We found...

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