Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion
The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control bra...
Gespeichert in:
| Veröffentlicht in: | Brain research 2001-07, Vol.907 (1), p.130-133 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 133 |
|---|---|
| container_issue | 1 |
| container_start_page | 130 |
| container_title | Brain research |
| container_volume | 907 |
| creator | Hayashi, Takeshi Seki, Tatsunori Sato, Keiko Iwai, Masanori Ri Zhang, Wen Manabe, Yasuhiro Abe, Koji |
| description | The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury. |
| doi_str_mv | 10.1016/S0006-8993(01)02543-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70972155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899301025434</els_id><sourcerecordid>70972155</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-c656e3bca88d1f443ad46a22e6a573b43f4eeb82f987dfc8ea4d11ce7027f2f63</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EokvhJ4B8AcEh4K8kzqlCVfmQKnEAztbEHgsjJ17sBHX_Pc7uih578lh-5vXM-xLykrP3nPHuw3fGWNfoYZBvGX_HRKtkox6RHde9aDqh2GOy-49ckGel_K5XKQf2lFxwriTTg9qRu5u7fcZSQppp8nSf4qEEiIcICzo645ohUosxUnC_8IhNKaJdI9Iw0wwLHTPUCvyCmS4Z5hJwXugUnKuMxYzjpgG5vh9osjaum8xz8sRDLPjifF6Sn59uflx_aW6_ff56_fG2sUqIpbFd26EcLWjtuFdKglMdCIEdtL0clfQKcdTCD7p33moE5Ti32DPRe-E7eUnenHT3Of1ZsSxmCmVbCGZMazE9G3rB2_ZBkGvW96rdFNsTaHMqJaM3-xwmyAfDmdmyMcdszGa8YdwcszGq9r06f7COE7r7rnMYFXh9BqBYiL56aUO55xTTLZfbpFcnDqtvfwNmU2z13KILGe1iXAoPjPIPKoGuDQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18077456</pqid></control><display><type>article</type><title>Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hayashi, Takeshi ; Seki, Tatsunori ; Sato, Keiko ; Iwai, Masanori ; Ri Zhang, Wen ; Manabe, Yasuhiro ; Abe, Koji</creator><creatorcontrib>Hayashi, Takeshi ; Seki, Tatsunori ; Sato, Keiko ; Iwai, Masanori ; Ri Zhang, Wen ; Manabe, Yasuhiro ; Abe, Koji</creatorcontrib><description>The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(01)02543-4</identifier><identifier>PMID: 11430894</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adhesion molecule ; Animals ; Biological and medical sciences ; Brain - metabolism ; Cell Division ; Cerebral Cortex - metabolism ; Corpus Striatum - metabolism ; Gene Expression Regulation ; Immunoenzyme Techniques ; Infarction, Middle Cerebral Artery - genetics ; Infarction, Middle Cerebral Artery - metabolism ; Ischemia ; Ischemic Attack, Transient - genetics ; Ischemic Attack, Transient - metabolism ; Male ; Medical sciences ; Neural Cell Adhesion Molecule L1 ; Neural Cell Adhesion Molecules - biosynthesis ; Neural Cell Adhesion Molecules - genetics ; Neurology ; Neuronal Plasticity - genetics ; Neurons - metabolism ; Plasticity ; Rats ; Rats, Wistar ; Reperfusion Injury - genetics ; Reperfusion Injury - metabolism ; Sialic Acids - biosynthesis ; Sialic Acids - genetics ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Brain research, 2001-07, Vol.907 (1), p.130-133</ispartof><rights>2001</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-c656e3bca88d1f443ad46a22e6a573b43f4eeb82f987dfc8ea4d11ce7027f2f63</citedby><cites>FETCH-LOGICAL-c422t-c656e3bca88d1f443ad46a22e6a573b43f4eeb82f987dfc8ea4d11ce7027f2f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899301025434$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14085135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11430894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Takeshi</creatorcontrib><creatorcontrib>Seki, Tatsunori</creatorcontrib><creatorcontrib>Sato, Keiko</creatorcontrib><creatorcontrib>Iwai, Masanori</creatorcontrib><creatorcontrib>Ri Zhang, Wen</creatorcontrib><creatorcontrib>Manabe, Yasuhiro</creatorcontrib><creatorcontrib>Abe, Koji</creatorcontrib><title>Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury.</description><subject>Adhesion molecule</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Cell Division</subject><subject>Cerebral Cortex - metabolism</subject><subject>Corpus Striatum - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Immunoenzyme Techniques</subject><subject>Infarction, Middle Cerebral Artery - genetics</subject><subject>Infarction, Middle Cerebral Artery - metabolism</subject><subject>Ischemia</subject><subject>Ischemic Attack, Transient - genetics</subject><subject>Ischemic Attack, Transient - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neural Cell Adhesion Molecule L1</subject><subject>Neural Cell Adhesion Molecules - biosynthesis</subject><subject>Neural Cell Adhesion Molecules - genetics</subject><subject>Neurology</subject><subject>Neuronal Plasticity - genetics</subject><subject>Neurons - metabolism</subject><subject>Plasticity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reperfusion Injury - genetics</subject><subject>Reperfusion Injury - metabolism</subject><subject>Sialic Acids - biosynthesis</subject><subject>Sialic Acids - genetics</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhJ4B8AcEh4K8kzqlCVfmQKnEAztbEHgsjJ17sBHX_Pc7uih578lh-5vXM-xLykrP3nPHuw3fGWNfoYZBvGX_HRKtkox6RHde9aDqh2GOy-49ckGel_K5XKQf2lFxwriTTg9qRu5u7fcZSQppp8nSf4qEEiIcICzo645ohUosxUnC_8IhNKaJdI9Iw0wwLHTPUCvyCmS4Z5hJwXugUnKuMxYzjpgG5vh9osjaum8xz8sRDLPjifF6Sn59uflx_aW6_ff56_fG2sUqIpbFd26EcLWjtuFdKglMdCIEdtL0clfQKcdTCD7p33moE5Ti32DPRe-E7eUnenHT3Of1ZsSxmCmVbCGZMazE9G3rB2_ZBkGvW96rdFNsTaHMqJaM3-xwmyAfDmdmyMcdszGa8YdwcszGq9r06f7COE7r7rnMYFXh9BqBYiL56aUO55xTTLZfbpFcnDqtvfwNmU2z13KILGe1iXAoPjPIPKoGuDQ</recordid><startdate>20010713</startdate><enddate>20010713</enddate><creator>Hayashi, Takeshi</creator><creator>Seki, Tatsunori</creator><creator>Sato, Keiko</creator><creator>Iwai, Masanori</creator><creator>Ri Zhang, Wen</creator><creator>Manabe, Yasuhiro</creator><creator>Abe, Koji</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010713</creationdate><title>Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion</title><author>Hayashi, Takeshi ; Seki, Tatsunori ; Sato, Keiko ; Iwai, Masanori ; Ri Zhang, Wen ; Manabe, Yasuhiro ; Abe, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-c656e3bca88d1f443ad46a22e6a573b43f4eeb82f987dfc8ea4d11ce7027f2f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adhesion molecule</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Cell Division</topic><topic>Cerebral Cortex - metabolism</topic><topic>Corpus Striatum - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Immunoenzyme Techniques</topic><topic>Infarction, Middle Cerebral Artery - genetics</topic><topic>Infarction, Middle Cerebral Artery - metabolism</topic><topic>Ischemia</topic><topic>Ischemic Attack, Transient - genetics</topic><topic>Ischemic Attack, Transient - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neural Cell Adhesion Molecule L1</topic><topic>Neural Cell Adhesion Molecules - biosynthesis</topic><topic>Neural Cell Adhesion Molecules - genetics</topic><topic>Neurology</topic><topic>Neuronal Plasticity - genetics</topic><topic>Neurons - metabolism</topic><topic>Plasticity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reperfusion Injury - genetics</topic><topic>Reperfusion Injury - metabolism</topic><topic>Sialic Acids - biosynthesis</topic><topic>Sialic Acids - genetics</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayashi, Takeshi</creatorcontrib><creatorcontrib>Seki, Tatsunori</creatorcontrib><creatorcontrib>Sato, Keiko</creatorcontrib><creatorcontrib>Iwai, Masanori</creatorcontrib><creatorcontrib>Ri Zhang, Wen</creatorcontrib><creatorcontrib>Manabe, Yasuhiro</creatorcontrib><creatorcontrib>Abe, Koji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayashi, Takeshi</au><au>Seki, Tatsunori</au><au>Sato, Keiko</au><au>Iwai, Masanori</au><au>Ri Zhang, Wen</au><au>Manabe, Yasuhiro</au><au>Abe, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2001-07-13</date><risdate>2001</risdate><volume>907</volume><issue>1</issue><spage>130</spage><epage>133</epage><pages>130-133</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>11430894</pmid><doi>10.1016/S0006-8993(01)02543-4</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2001-07, Vol.907 (1), p.130-133 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70972155 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adhesion molecule Animals Biological and medical sciences Brain - metabolism Cell Division Cerebral Cortex - metabolism Corpus Striatum - metabolism Gene Expression Regulation Immunoenzyme Techniques Infarction, Middle Cerebral Artery - genetics Infarction, Middle Cerebral Artery - metabolism Ischemia Ischemic Attack, Transient - genetics Ischemic Attack, Transient - metabolism Male Medical sciences Neural Cell Adhesion Molecule L1 Neural Cell Adhesion Molecules - biosynthesis Neural Cell Adhesion Molecules - genetics Neurology Neuronal Plasticity - genetics Neurons - metabolism Plasticity Rats Rats, Wistar Reperfusion Injury - genetics Reperfusion Injury - metabolism Sialic Acids - biosynthesis Sialic Acids - genetics Vascular diseases and vascular malformations of the nervous system |
| title | Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T08%3A01%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20polysialylated%20neural%20cell%20adhesion%20molecule%20in%20rat%20brain%20after%20transient%20middle%20cerebral%20artery%20occlusion&rft.jtitle=Brain%20research&rft.au=Hayashi,%20Takeshi&rft.date=2001-07-13&rft.volume=907&rft.issue=1&rft.spage=130&rft.epage=133&rft.pages=130-133&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/S0006-8993(01)02543-4&rft_dat=%3Cproquest_cross%3E70972155%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18077456&rft_id=info:pmid/11430894&rft_els_id=S0006899301025434&rfr_iscdi=true |