High Prevalence of Varicella-Zoster Virus Reactivation in Herpes Simplex Virus-Seronegative Patients with Acute Peripheral Facial Palsy
Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are considered to be the major causes of acute peripheral facial palsy (APFP). One hundred and forty-two patients with APFP were analyzed by serological assays and polymerase chain reaction analysis. Ramsay Hunt syndrome was diagnosed in 21...
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| Veröffentlicht in: | Clinical infectious diseases 2000-03, Vol.30 (3), p.529-533 |
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| creator | Furuta, Yasushi Ohtani, Fumio Kawabata, Hiroki Fukuda, Satoshi Bergström, Tomas |
| description | Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are considered to be the major causes of acute peripheral facial palsy (APFP). One hundred and forty-two patients with APFP were analyzed by serological assays and polymerase chain reaction analysis. Ramsay Hunt syndrome was diagnosed in 21 patients. Of the remaining 121 patients clinically diagnosed with Bell's palsy, VZV reactivation without zoster (zoster sine herpete) was detected in 35 patients (29%). The prevalence of antibodies to HSV among patients with Bell's palsy was significantly higher than the prevalence among those with VZV reactivation (Ramsay Hunt syndrome or zoster sine herpete). In contrast, a high incidence (88%) of VZV reactivation among HSV-seronegative patients with APFP was observed. Our data indicate that VZV is one of the major etiologic agents of clinically diagnosed Bell's palsy and that VZV reactivation causes APFP in most patients who lack antibodies to HSV. |
| doi_str_mv | 10.1086/313721 |
| format | Article |
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One hundred and forty-two patients with APFP were analyzed by serological assays and polymerase chain reaction analysis. Ramsay Hunt syndrome was diagnosed in 21 patients. Of the remaining 121 patients clinically diagnosed with Bell's palsy, VZV reactivation without zoster (zoster sine herpete) was detected in 35 patients (29%). The prevalence of antibodies to HSV among patients with Bell's palsy was significantly higher than the prevalence among those with VZV reactivation (Ramsay Hunt syndrome or zoster sine herpete). In contrast, a high incidence (88%) of VZV reactivation among HSV-seronegative patients with APFP was observed. Our data indicate that VZV is one of the major etiologic agents of clinically diagnosed Bell's palsy and that VZV reactivation causes APFP in most patients who lack antibodies to HSV.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/313721</identifier><identifier>PMID: 10722439</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>acute peripheral facial palsy ; Adolescent ; Adult ; Age Distribution ; Aged ; Antibodies ; Antibodies, Viral - blood ; Antigens ; Bell palsy ; Bell Palsy - pathology ; Bell Palsy - virology ; Biological and medical sciences ; Child ; Child, Preschool ; Clinical Articles ; Facial paralysis ; Facial Paralysis - pathology ; Facial Paralysis - virology ; Herpes Simplex - complications ; Herpes Simplex - virology ; Herpes simplex virus ; Herpes zoster ; Herpes Zoster - complications ; Herpes Zoster - virology ; Herpesvirus 3, Human - genetics ; Herpesvirus 3, Human - physiology ; Human herpesvirus 1 ; Human herpesvirus 2 ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Middle Aged ; Peripheral Nervous System Diseases - pathology ; Peripheral Nervous System Diseases - virology ; Polymerase Chain Reaction ; Prevalence ; Simplexvirus ; Simplexvirus - immunology ; Varicella zoster encephalitis ; Varicella-zoster virus ; Viral diseases ; Viral diseases of the nervous system ; Virus Activation</subject><ispartof>Clinical infectious diseases, 2000-03, Vol.30 (3), p.529-533</ispartof><rights>Copyright 2000 The Infectious Diseases Society of America</rights><rights>2000 by the Infectious Diseases Society of America 2000</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-25926391fd1d4fc075551de0ee254d9436392fd069b6a6450f027e5e644072303</citedby><cites>FETCH-LOGICAL-c452t-25926391fd1d4fc075551de0ee254d9436392fd069b6a6450f027e5e644072303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4461078$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4461078$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1334720$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10722439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furuta, Yasushi</creatorcontrib><creatorcontrib>Ohtani, Fumio</creatorcontrib><creatorcontrib>Kawabata, Hiroki</creatorcontrib><creatorcontrib>Fukuda, Satoshi</creatorcontrib><creatorcontrib>Bergström, Tomas</creatorcontrib><title>High Prevalence of Varicella-Zoster Virus Reactivation in Herpes Simplex Virus-Seronegative Patients with Acute Peripheral Facial Palsy</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are considered to be the major causes of acute peripheral facial palsy (APFP). One hundred and forty-two patients with APFP were analyzed by serological assays and polymerase chain reaction analysis. Ramsay Hunt syndrome was diagnosed in 21 patients. Of the remaining 121 patients clinically diagnosed with Bell's palsy, VZV reactivation without zoster (zoster sine herpete) was detected in 35 patients (29%). The prevalence of antibodies to HSV among patients with Bell's palsy was significantly higher than the prevalence among those with VZV reactivation (Ramsay Hunt syndrome or zoster sine herpete). In contrast, a high incidence (88%) of VZV reactivation among HSV-seronegative patients with APFP was observed. Our data indicate that VZV is one of the major etiologic agents of clinically diagnosed Bell's palsy and that VZV reactivation causes APFP in most patients who lack antibodies to HSV.</description><subject>acute peripheral facial palsy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens</subject><subject>Bell palsy</subject><subject>Bell Palsy - pathology</subject><subject>Bell Palsy - virology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Articles</subject><subject>Facial paralysis</subject><subject>Facial Paralysis - pathology</subject><subject>Facial Paralysis - virology</subject><subject>Herpes Simplex - complications</subject><subject>Herpes Simplex - virology</subject><subject>Herpes simplex virus</subject><subject>Herpes zoster</subject><subject>Herpes Zoster - complications</subject><subject>Herpes Zoster - virology</subject><subject>Herpesvirus 3, Human - genetics</subject><subject>Herpesvirus 3, Human - physiology</subject><subject>Human herpesvirus 1</subject><subject>Human herpesvirus 2</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peripheral Nervous System Diseases - pathology</subject><subject>Peripheral Nervous System Diseases - virology</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>Simplexvirus</subject><subject>Simplexvirus - immunology</subject><subject>Varicella zoster encephalitis</subject><subject>Varicella-zoster virus</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><subject>Virus Activation</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhSMEoqXAEyBkJMQu4H87y7ZiGKRKjKYwoNlYrnPTccnEwU6G9gl4bVwyatkgVsfy-XSvzj1F8ZzgtwRr-Y4Rpih5UBwSwVQpRUUe5jcWuuSa6YPiSUpXGBOisXhcHBCsKOWsOix-zf3lBi0i7GwLnQMUGrSy0TtoW1uuQxogopWPY0JLsG7wOzv40CHfoTnEHhI699u-hesJKs8hhg4uM7QDtMgC3ZDQTz9s0LEbh_wH0fcbiLZFM-t8loVt083T4lGTFZ7t9aj4Mnv_-XRenn368PH0-Kx0XNChpKKiklWkqUnNG4eVEILUgAGo4HXFWTZpU2NZXUgrucANpgoESM5zZIbZUfFmmtvH8GOENJitT3_CdhDGZBSuVD6h_C9IlNaKEXIPuhhSitCYPvqtjTeGYHPbjZm6yeDL_cTxYgv1X9hURgZe7wGbnG2baDvn0z3HGFf0NsKrCQtj_-9dLybmKg0h3lGcy7xNZ7ucbJ_7vb6zbfxupGJKmPm3tVktl_rriVibGfsNwTy4CQ</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Furuta, Yasushi</creator><creator>Ohtani, Fumio</creator><creator>Kawabata, Hiroki</creator><creator>Fukuda, Satoshi</creator><creator>Bergström, Tomas</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000301</creationdate><title>High Prevalence of Varicella-Zoster Virus Reactivation in Herpes Simplex Virus-Seronegative Patients with Acute Peripheral Facial Palsy</title><author>Furuta, Yasushi ; Ohtani, Fumio ; Kawabata, Hiroki ; Fukuda, Satoshi ; Bergström, Tomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-25926391fd1d4fc075551de0ee254d9436392fd069b6a6450f027e5e644072303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>acute peripheral facial palsy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Antigens</topic><topic>Bell palsy</topic><topic>Bell Palsy - pathology</topic><topic>Bell Palsy - virology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Articles</topic><topic>Facial paralysis</topic><topic>Facial Paralysis - pathology</topic><topic>Facial Paralysis - virology</topic><topic>Herpes Simplex - complications</topic><topic>Herpes Simplex - virology</topic><topic>Herpes simplex virus</topic><topic>Herpes zoster</topic><topic>Herpes Zoster - complications</topic><topic>Herpes Zoster - virology</topic><topic>Herpesvirus 3, Human - genetics</topic><topic>Herpesvirus 3, Human - physiology</topic><topic>Human herpesvirus 1</topic><topic>Human herpesvirus 2</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peripheral Nervous System Diseases - pathology</topic><topic>Peripheral Nervous System Diseases - virology</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>Simplexvirus</topic><topic>Simplexvirus - immunology</topic><topic>Varicella zoster encephalitis</topic><topic>Varicella-zoster virus</topic><topic>Viral diseases</topic><topic>Viral diseases of the nervous system</topic><topic>Virus Activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furuta, Yasushi</creatorcontrib><creatorcontrib>Ohtani, Fumio</creatorcontrib><creatorcontrib>Kawabata, Hiroki</creatorcontrib><creatorcontrib>Fukuda, Satoshi</creatorcontrib><creatorcontrib>Bergström, Tomas</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furuta, Yasushi</au><au>Ohtani, Fumio</au><au>Kawabata, Hiroki</au><au>Fukuda, Satoshi</au><au>Bergström, Tomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Prevalence of Varicella-Zoster Virus Reactivation in Herpes Simplex Virus-Seronegative Patients with Acute Peripheral Facial Palsy</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>30</volume><issue>3</issue><spage>529</spage><epage>533</epage><pages>529-533</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are considered to be the major causes of acute peripheral facial palsy (APFP). One hundred and forty-two patients with APFP were analyzed by serological assays and polymerase chain reaction analysis. Ramsay Hunt syndrome was diagnosed in 21 patients. Of the remaining 121 patients clinically diagnosed with Bell's palsy, VZV reactivation without zoster (zoster sine herpete) was detected in 35 patients (29%). The prevalence of antibodies to HSV among patients with Bell's palsy was significantly higher than the prevalence among those with VZV reactivation (Ramsay Hunt syndrome or zoster sine herpete). In contrast, a high incidence (88%) of VZV reactivation among HSV-seronegative patients with APFP was observed. Our data indicate that VZV is one of the major etiologic agents of clinically diagnosed Bell's palsy and that VZV reactivation causes APFP in most patients who lack antibodies to HSV.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10722439</pmid><doi>10.1086/313721</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical infectious diseases, 2000-03, Vol.30 (3), p.529-533 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | acute peripheral facial palsy Adolescent Adult Age Distribution Aged Antibodies Antibodies, Viral - blood Antigens Bell palsy Bell Palsy - pathology Bell Palsy - virology Biological and medical sciences Child Child, Preschool Clinical Articles Facial paralysis Facial Paralysis - pathology Facial Paralysis - virology Herpes Simplex - complications Herpes Simplex - virology Herpes simplex virus Herpes zoster Herpes Zoster - complications Herpes Zoster - virology Herpesvirus 3, Human - genetics Herpesvirus 3, Human - physiology Human herpesvirus 1 Human herpesvirus 2 Human viral diseases Humans Infectious diseases Medical sciences Middle Aged Peripheral Nervous System Diseases - pathology Peripheral Nervous System Diseases - virology Polymerase Chain Reaction Prevalence Simplexvirus Simplexvirus - immunology Varicella zoster encephalitis Varicella-zoster virus Viral diseases Viral diseases of the nervous system Virus Activation |
| title | High Prevalence of Varicella-Zoster Virus Reactivation in Herpes Simplex Virus-Seronegative Patients with Acute Peripheral Facial Palsy |
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