Allopurinol Normalizes Endothelial Dysfunction in Type 2 Diabetics With Mild Hypertension

ABSTRACTTherapeutic strategies against free radicals have mostly focused on the augmentation of antioxidant defenses (eg, vitamins C and E). A novel approach is to prevent free radical generation by the enzyme system xanthine oxidase. We examined whether the inhibition of xanthine oxidase with allop...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-03, Vol.35 (3), p.746-751
Hauptverfasser:	Butler, Robert, Morris, Andrew D, Belch, Jill J. F, Hill, Alexander, Struthers, Allan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Allopurinol - administration & dosage Antihypertensive agents Biological and medical sciences Cardiovascular system Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Diabetic Angiopathies - drug therapy Diabetic Angiopathies - enzymology Endothelium, Vascular - enzymology Enzyme Inhibitors - administration & dosage Female Forearm - blood supply Free Radical Scavengers - administration & dosage Glycated Hemoglobin A - analysis Humans Hypertension - complications Hypertension - drug therapy Hypertension - enzymology Male Malondialdehyde - metabolism Medical sciences Middle Aged Nitroprusside - administration & dosage Pharmacology. Drug treatments Plethysmography Regional Blood Flow - drug effects Regression Analysis Vasodilator Agents - administration & dosage Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - metabolism
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