A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock

Tissue-specific overexpression of the glycogen synthase kinase-3 (GSK-3) ortholog shaggy ( sgg) shortens the period of the Drosophila circadian locomotor activity cycle. The short period phenotype was attributed to premature nuclear translocation of the PERIOD/TIMELESS heterodimer. Reducing SGG/GSK-...

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Veröffentlicht in:	Cell 2001-06, Vol.105 (6), p.769-779
Hauptverfasser:	Martinek, Sebastian, Inonog, Susan, Manoukian, Armen S., Young, Michael W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Biological Clocks - genetics Biological Clocks - physiology Cell Nucleus - metabolism Circadian Rhythm - genetics Circadian Rhythm - physiology Dimerization Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila Proteins Glycogen Synthase Kinase 3 Immunoblotting Insect Proteins - genetics Insect Proteins - metabolism Microscopy, Fluorescence Motor Activity - genetics Motor Activity - physiology Nuclear Proteins - metabolism Period Circadian Proteins Period protein Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA - genetics RNA - metabolism shaggy (sgg) gene Timeless protein
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