Complementarity and redundancy of the binding specificity of HLA‐DRB1, ‐DRB3, ‐DRB4 and ‐DRB5 molecules

The second HLA‐DR molecules, which are encoded by loci different from HLA‐DRB1 are weakly polymorphic. Predominant alleles such as HLA‐DRB3*0101, HLA‐DRB4*0101 and HLA‐DRB5*0101 are therefore interesting targets to define antigenic peptides with major impact for the entire population. Strikingly, th...

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