γ-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats
Food intake is significantly increased by administration of μ-selective opioid agonists into the nucleus accumbens, particularly its shell region. Pretreatment with either opioid (μ, δ 1, δ 2 or κ 1) or dopaminergic (D 1) receptor antagonists in the nucleus accumbens shell reduce μ opioid agonist-in...
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| Veröffentlicht in: | Brain research 2001-07, Vol.906 (1), p.84-91 |
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| creator | Znamensky, Vladimir Echo, Joyce A Lamonte, Nicole Christian, Garrison Ragnauth, André Bodnar, Richard J |
| description | Food intake is significantly increased by administration of μ-selective opioid agonists into the nucleus accumbens, particularly its shell region. Pretreatment with either opioid (μ, δ
1, δ
2 or κ
1) or dopaminergic (D
1) receptor antagonists in the nucleus accumbens shell reduce μ opioid agonist-induced feeding. Selective GABA
A (muscimol) and GABA
B (baclofen) agonists administered into the nucleus accumbens shell each stimulate feeding which is respectively and selectively blocked by GABA
A (bicuculline) and GABA
B (saclofen) antagonists. The present study investigated whether feeding elicited by the μ-selective opioid agonist, [
d-Ala
2,NMe
4,Gly-ol
5]-enkephalin in the nucleus accumbens shell was decreased by intra-accumbens pretreatment with an equimolar dose range of either GABA
A or GABA
B antagonists, and further, whether general opioid or selective GABA antagonists decreased feeding elicited by GABA
A or GABA
B agonists in the nucleus accumbens shell. Feeding elicited by the μ-selective opioid agonist was dose-dependently increased following intra-accumbens pretreatment with GABA
A (bicuculline) antagonism; this enhancement was significantly blocked by pretreatment with general or μ-selective opioid antagonists. In contrast, μ opioid agonist-induced feeding elicited from the nucleus accumbens shell was dose-dependently decreased by GABA
B (saclofen) antagonism. Neither bicuculline nor saclofen in the nucleus accumbens shell altered baseline food intake. Whereas muscimol-induced feeding elicited from the nucleus accumbens shell was reduced by bicuculline and naltrexone, but not saclofen pretreatment, baclofen-induced feeding elicited from the nucleus accumbens shell was reduced by saclofen, but not by bicuculline or naltrexone. These data indicate that GABA
A and GABA
B receptor subtype antagonists differentially affect feeding elicited by μ opioid receptor agonists within the nucleus accumbens shell in rats. |
| doi_str_mv | 10.1016/S0006-8993(01)02558-6 |
| format | Article |
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1, δ
2 or κ
1) or dopaminergic (D
1) receptor antagonists in the nucleus accumbens shell reduce μ opioid agonist-induced feeding. Selective GABA
A (muscimol) and GABA
B (baclofen) agonists administered into the nucleus accumbens shell each stimulate feeding which is respectively and selectively blocked by GABA
A (bicuculline) and GABA
B (saclofen) antagonists. The present study investigated whether feeding elicited by the μ-selective opioid agonist, [
d-Ala
2,NMe
4,Gly-ol
5]-enkephalin in the nucleus accumbens shell was decreased by intra-accumbens pretreatment with an equimolar dose range of either GABA
A or GABA
B antagonists, and further, whether general opioid or selective GABA antagonists decreased feeding elicited by GABA
A or GABA
B agonists in the nucleus accumbens shell. Feeding elicited by the μ-selective opioid agonist was dose-dependently increased following intra-accumbens pretreatment with GABA
A (bicuculline) antagonism; this enhancement was significantly blocked by pretreatment with general or μ-selective opioid antagonists. In contrast, μ opioid agonist-induced feeding elicited from the nucleus accumbens shell was dose-dependently decreased by GABA
B (saclofen) antagonism. Neither bicuculline nor saclofen in the nucleus accumbens shell altered baseline food intake. Whereas muscimol-induced feeding elicited from the nucleus accumbens shell was reduced by bicuculline and naltrexone, but not saclofen pretreatment, baclofen-induced feeding elicited from the nucleus accumbens shell was reduced by saclofen, but not by bicuculline or naltrexone. These data indicate that GABA
A and GABA
B receptor subtype antagonists differentially affect feeding elicited by μ opioid receptor agonists within the nucleus accumbens shell in rats.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(01)02558-6</identifier><identifier>PMID: 11430864</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Baclofen ; Baclofen - analogs & derivatives ; Baclofen - pharmacology ; Bicuculline ; Bicuculline - pharmacology ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Eating - drug effects ; Eating - physiology ; Enkephalin, Ala-MePhe-Gly- - pharmacology ; Feeding ; Fundamental and applied biological sciences. Psychology ; GABA A receptor ; GABA Agonists - pharmacology ; GABA Antagonists - pharmacology ; GABA B receptor ; GABA-A Receptor Antagonists ; GABA-B Receptor Antagonists ; gamma-Aminobutyric Acid - metabolism ; Male ; Muscimol ; Naltrexone - analogs & derivatives ; Naltrexone - pharmacology ; Narcotic Antagonists - pharmacology ; Narcotics - metabolism ; Narcotics - pharmacology ; Neurons - cytology ; Neurons - drug effects ; Neurons - metabolism ; Nucleus Accumbens - cytology ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Nucleus accumbens shell ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA - drug effects ; Receptors, GABA - metabolism ; Receptors, GABA-A - metabolism ; Receptors, GABA-B - metabolism ; Receptors, Opioid - drug effects ; Receptors, Opioid - metabolism ; Saclofen ; Vertebrates: nervous system and sense organs ; μ Opioid receptor</subject><ispartof>Brain research, 2001-07, Vol.906 (1), p.84-91</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-f76b4703c6cbd332f2bb352d1f00be26e33644f5e120bfbeb187c51b5380e4263</citedby><cites>FETCH-LOGICAL-c422t-f76b4703c6cbd332f2bb352d1f00be26e33644f5e120bfbeb187c51b5380e4263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(01)02558-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14081778$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11430864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Znamensky, Vladimir</creatorcontrib><creatorcontrib>Echo, Joyce A</creatorcontrib><creatorcontrib>Lamonte, Nicole</creatorcontrib><creatorcontrib>Christian, Garrison</creatorcontrib><creatorcontrib>Ragnauth, André</creatorcontrib><creatorcontrib>Bodnar, Richard J</creatorcontrib><title>γ-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Food intake is significantly increased by administration of μ-selective opioid agonists into the nucleus accumbens, particularly its shell region. Pretreatment with either opioid (μ, δ
1, δ
2 or κ
1) or dopaminergic (D
1) receptor antagonists in the nucleus accumbens shell reduce μ opioid agonist-induced feeding. Selective GABA
A (muscimol) and GABA
B (baclofen) agonists administered into the nucleus accumbens shell each stimulate feeding which is respectively and selectively blocked by GABA
A (bicuculline) and GABA
B (saclofen) antagonists. The present study investigated whether feeding elicited by the μ-selective opioid agonist, [
d-Ala
2,NMe
4,Gly-ol
5]-enkephalin in the nucleus accumbens shell was decreased by intra-accumbens pretreatment with an equimolar dose range of either GABA
A or GABA
B antagonists, and further, whether general opioid or selective GABA antagonists decreased feeding elicited by GABA
A or GABA
B agonists in the nucleus accumbens shell. Feeding elicited by the μ-selective opioid agonist was dose-dependently increased following intra-accumbens pretreatment with GABA
A (bicuculline) antagonism; this enhancement was significantly blocked by pretreatment with general or μ-selective opioid antagonists. In contrast, μ opioid agonist-induced feeding elicited from the nucleus accumbens shell was dose-dependently decreased by GABA
B (saclofen) antagonism. Neither bicuculline nor saclofen in the nucleus accumbens shell altered baseline food intake. Whereas muscimol-induced feeding elicited from the nucleus accumbens shell was reduced by bicuculline and naltrexone, but not saclofen pretreatment, baclofen-induced feeding elicited from the nucleus accumbens shell was reduced by saclofen, but not by bicuculline or naltrexone. These data indicate that GABA
A and GABA
B receptor subtype antagonists differentially affect feeding elicited by μ opioid receptor agonists within the nucleus accumbens shell in rats.</description><subject>Animals</subject><subject>Baclofen</subject><subject>Baclofen - analogs & derivatives</subject><subject>Baclofen - pharmacology</subject><subject>Bicuculline</subject><subject>Bicuculline - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Eating - drug effects</subject><subject>Eating - physiology</subject><subject>Enkephalin, Ala-MePhe-Gly- - pharmacology</subject><subject>Feeding</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA A receptor</subject><subject>GABA Agonists - pharmacology</subject><subject>GABA Antagonists - pharmacology</subject><subject>GABA B receptor</subject><subject>GABA-A Receptor Antagonists</subject><subject>GABA-B Receptor Antagonists</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Male</subject><subject>Muscimol</subject><subject>Naltrexone - analogs & derivatives</subject><subject>Naltrexone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Narcotics - metabolism</subject><subject>Narcotics - pharmacology</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Nucleus Accumbens - cytology</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Nucleus accumbens shell</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, GABA - drug effects</subject><subject>Receptors, GABA - metabolism</subject><subject>Receptors, GABA-A - metabolism</subject><subject>Receptors, GABA-B - metabolism</subject><subject>Receptors, Opioid - drug effects</subject><subject>Receptors, Opioid - metabolism</subject><subject>Saclofen</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>μ Opioid receptor</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuKFTEUhoMo9vXqEpRMFB2U5lWpqlHTNL6gwYE6Dknq5HakKimTlHC34Vbch2sy94E97FFI-HLOz_8h9JySt5RQ-e4rIUQ2_TDw14S-Iaxt-0Y-QBvad6yRTJCHaPMfuUBPcv5Rr5wP5DG6oFRw0kuxQb___mmuZh-iWcs-eYu19SNOYGEpMeG8mrJfAOtQ9C4Gn0vGo3cOEoTi9TTtsZ4KJBwXH_3Y-DCuFkbsAEYfdtgHXG4B51uYpjp152PA0R3fwmonWHNdaNfZQMgHOOmSn6JHTk8Znp3PLfr-4f2360_NzZePn6-vbhorGCuN66QRHeFWWjNyzhwzhrdspI4QA0wC51II1wJlxDgDpjZjW2pa3hMQTPItenWau6T4c4Vc1OyzrUF1gLhm1ZFBDrzt7gVpT7pB1G63qD2BNsWcEzi1JD_rtFeUqIM1dbSmDkoUoepoTR2SvDgvWM0M492vs6YKvDwDOls9uaSD9fmOE6SnXddX7vLEQe3tl4eksvUQqhFflRY1Rn9PlH9_5Ld7</recordid><startdate>20010706</startdate><enddate>20010706</enddate><creator>Znamensky, Vladimir</creator><creator>Echo, Joyce A</creator><creator>Lamonte, Nicole</creator><creator>Christian, Garrison</creator><creator>Ragnauth, André</creator><creator>Bodnar, Richard J</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010706</creationdate><title>γ-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats</title><author>Znamensky, Vladimir ; Echo, Joyce A ; Lamonte, Nicole ; Christian, Garrison ; Ragnauth, André ; Bodnar, Richard J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-f76b4703c6cbd332f2bb352d1f00be26e33644f5e120bfbeb187c51b5380e4263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Baclofen</topic><topic>Baclofen - analogs & derivatives</topic><topic>Baclofen - pharmacology</topic><topic>Bicuculline</topic><topic>Bicuculline - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Eating - drug effects</topic><topic>Eating - physiology</topic><topic>Enkephalin, Ala-MePhe-Gly- - pharmacology</topic><topic>Feeding</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA A receptor</topic><topic>GABA Agonists - pharmacology</topic><topic>GABA Antagonists - pharmacology</topic><topic>GABA B receptor</topic><topic>GABA-A Receptor Antagonists</topic><topic>GABA-B Receptor Antagonists</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Male</topic><topic>Muscimol</topic><topic>Naltrexone - analogs & derivatives</topic><topic>Naltrexone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Narcotics - metabolism</topic><topic>Narcotics - pharmacology</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Nucleus Accumbens - cytology</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Nucleus accumbens shell</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, GABA - drug effects</topic><topic>Receptors, GABA - metabolism</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Receptors, GABA-B - metabolism</topic><topic>Receptors, Opioid - drug effects</topic><topic>Receptors, Opioid - metabolism</topic><topic>Saclofen</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>μ Opioid receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Znamensky, Vladimir</creatorcontrib><creatorcontrib>Echo, Joyce A</creatorcontrib><creatorcontrib>Lamonte, Nicole</creatorcontrib><creatorcontrib>Christian, Garrison</creatorcontrib><creatorcontrib>Ragnauth, André</creatorcontrib><creatorcontrib>Bodnar, Richard J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Znamensky, Vladimir</au><au>Echo, Joyce A</au><au>Lamonte, Nicole</au><au>Christian, Garrison</au><au>Ragnauth, André</au><au>Bodnar, Richard J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>γ-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2001-07-06</date><risdate>2001</risdate><volume>906</volume><issue>1</issue><spage>84</spage><epage>91</epage><pages>84-91</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Food intake is significantly increased by administration of μ-selective opioid agonists into the nucleus accumbens, particularly its shell region. Pretreatment with either opioid (μ, δ
1, δ
2 or κ
1) or dopaminergic (D
1) receptor antagonists in the nucleus accumbens shell reduce μ opioid agonist-induced feeding. Selective GABA
A (muscimol) and GABA
B (baclofen) agonists administered into the nucleus accumbens shell each stimulate feeding which is respectively and selectively blocked by GABA
A (bicuculline) and GABA
B (saclofen) antagonists. The present study investigated whether feeding elicited by the μ-selective opioid agonist, [
d-Ala
2,NMe
4,Gly-ol
5]-enkephalin in the nucleus accumbens shell was decreased by intra-accumbens pretreatment with an equimolar dose range of either GABA
A or GABA
B antagonists, and further, whether general opioid or selective GABA antagonists decreased feeding elicited by GABA
A or GABA
B agonists in the nucleus accumbens shell. Feeding elicited by the μ-selective opioid agonist was dose-dependently increased following intra-accumbens pretreatment with GABA
A (bicuculline) antagonism; this enhancement was significantly blocked by pretreatment with general or μ-selective opioid antagonists. In contrast, μ opioid agonist-induced feeding elicited from the nucleus accumbens shell was dose-dependently decreased by GABA
B (saclofen) antagonism. Neither bicuculline nor saclofen in the nucleus accumbens shell altered baseline food intake. Whereas muscimol-induced feeding elicited from the nucleus accumbens shell was reduced by bicuculline and naltrexone, but not saclofen pretreatment, baclofen-induced feeding elicited from the nucleus accumbens shell was reduced by saclofen, but not by bicuculline or naltrexone. These data indicate that GABA
A and GABA
B receptor subtype antagonists differentially affect feeding elicited by μ opioid receptor agonists within the nucleus accumbens shell in rats.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>11430864</pmid><doi>10.1016/S0006-8993(01)02558-6</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Brain research, 2001-07, Vol.906 (1), p.84-91 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70969357 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Baclofen Baclofen - analogs & derivatives Baclofen - pharmacology Bicuculline Bicuculline - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Eating - drug effects Eating - physiology Enkephalin, Ala-MePhe-Gly- - pharmacology Feeding Fundamental and applied biological sciences. Psychology GABA A receptor GABA Agonists - pharmacology GABA Antagonists - pharmacology GABA B receptor GABA-A Receptor Antagonists GABA-B Receptor Antagonists gamma-Aminobutyric Acid - metabolism Male Muscimol Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists - pharmacology Narcotics - metabolism Narcotics - pharmacology Neurons - cytology Neurons - drug effects Neurons - metabolism Nucleus Accumbens - cytology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Nucleus accumbens shell Rats Rats, Sprague-Dawley Receptors, GABA - drug effects Receptors, GABA - metabolism Receptors, GABA-A - metabolism Receptors, GABA-B - metabolism Receptors, Opioid - drug effects Receptors, Opioid - metabolism Saclofen Vertebrates: nervous system and sense organs μ Opioid receptor |
| title | γ-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats |
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