A Comparison of the Transient Hyperemic Response Test and the Static Autoregulation Test to Assess Graded Impairment in Cerebral Autoregulation During Propofol, Desflurane, and Nitrous Oxide Anesthesia
The transient hyperemic response (THR) test has been used to assess cerebral autoregulation in anesthesia and intensive care. To date it has not been compared with the static autoregulation test for assessing graded changes in cerebral autoregulation. We compared the two tests during propofol, desfl...
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| Veröffentlicht in: | Anesthesia and analgesia 2001-07, Vol.93 (1), p.171-176 |
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| creator | Tibble, Rachel K. Girling, Keith J. Mahajan, Ravi P. |
| description | The transient hyperemic response (THR) test has been used to assess cerebral autoregulation in anesthesia and intensive care. To date it has not been compared with the static autoregulation test for assessing graded changes in cerebral autoregulation. We compared the two tests during propofol, desflurane, and nitrous oxide anesthesia. Seven subjects were studied. For the THR test, changes in the middle artery blood flow velocity were assessed during and after a 10-s compression of the ipsilateral common carotid artery. Two indices of autoregulation--THR ratio (THRR) and strength of autoregulation (SA)--were calculated. For the test of static autoregulation, changes in the middle cerebral artery flow velocity after a phenylephrine-induces increase in mean arterial pressure were assessed, and the static rate of regulation (sROR) was calculated. The tests were performed before induction and after equilibrium at 0.5 minimum alveolar anesthetic concentration (MAC) and then at 1.5 MAC of desflurane. THRR, SA and sROR decreased significantly (P < 0.001) at 0.5 MAC and then at 1.5 MAC desflurane. CHanges in THRR and SA reflected the changes in sROR with a sensitivity of 100%.
When compared with the established test of static autoregulation, the transient hyperemic response test provides a valid method for assessing graded impairment in cerebral autoregulation. |
| doi_str_mv | 10.1097/00000539-200107000-00034 |
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When compared with the established test of static autoregulation, the transient hyperemic response test provides a valid method for assessing graded impairment in cerebral autoregulation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Algorithms</subject><subject>Anesthesia, Inhalation</subject><subject>Anesthesia, Intravenous</subject><subject>Anesthetics, Inhalation</subject><subject>Anesthetics, Intravenous</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Desflurane</subject><subject>Female</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Hyperemia - physiopathology</subject><subject>Investigative techniques of hemodynamics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Isoflurane - analogs & derivatives</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitrous Oxide</subject><subject>Propofol</subject><subject>Ultrasonography, Doppler, Transcranial</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kttu1DAQhi0EokvhFZAvEFdNsXP25Wpb2koVRVCuLScZdw1OHDyJSh-Rt-pkdzkICUs-fzP_yL8Z41KcSqGqd2JpRaaSVAgpKtok1LP8CVvJIi2TqlD1U7ZazpJUKXXEXiB-FQtcl8_ZkZR5qrJSrNjPNd-EfjTRYRh4sHzaAr-NZkAHw8QvH0aI0LuWfwIcw4B0CThxM3Q78vNkJrpcz1OIcDd72lGaHTIFvkYERH4RTQcdvyIZF_slrRv4hvI20fh_Y8_m6IY7_jGGMdjgT_gZoPUzVQQnO9kPbophRn7zw3XA1wNpbQGdecmeWeMRXh3mY_bl_fnt5jK5vrm42qyvkzarizxpbWu7vBKmTLs2paExRVa1UuQldEVaybqymakLmVuwomlM3XS0VvRwnbF1mh2zt_u8YwzfZ1LXvcMWvKcKqS5dCVWqtKwJrPdgGwNiBKvH6HoTH7QUerFR_7JR_7ZR72yk0NcHjbnpofsTePCNgDcHwGBrvKXnaR3-JVCIuigJy_fYffATRPzm53uIegvGT1v9v1-UPQJSYbjN</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Tibble, Rachel K.</creator><creator>Girling, Keith J.</creator><creator>Mahajan, Ravi P.</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>A Comparison of the Transient Hyperemic Response Test and the Static Autoregulation Test to Assess Graded Impairment in Cerebral Autoregulation During Propofol, Desflurane, and Nitrous Oxide Anesthesia</title><author>Tibble, Rachel K. ; Girling, Keith J. ; Mahajan, Ravi P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3854-cfcfd470a62dc262dba537c1046ed527187f3a8514fef0bba8bd14f9086daf823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Algorithms</topic><topic>Anesthesia, Inhalation</topic><topic>Anesthesia, Intravenous</topic><topic>Anesthetics, Inhalation</topic><topic>Anesthetics, Intravenous</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Desflurane</topic><topic>Female</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Hyperemia - physiopathology</topic><topic>Investigative techniques of hemodynamics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Isoflurane - analogs & derivatives</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitrous Oxide</topic><topic>Propofol</topic><topic>Ultrasonography, Doppler, Transcranial</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tibble, Rachel K.</creatorcontrib><creatorcontrib>Girling, Keith J.</creatorcontrib><creatorcontrib>Mahajan, Ravi P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tibble, Rachel K.</au><au>Girling, Keith J.</au><au>Mahajan, Ravi P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of the Transient Hyperemic Response Test and the Static Autoregulation Test to Assess Graded Impairment in Cerebral Autoregulation During Propofol, Desflurane, and Nitrous Oxide Anesthesia</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>93</volume><issue>1</issue><spage>171</spage><epage>176</epage><pages>171-176</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>The transient hyperemic response (THR) test has been used to assess cerebral autoregulation in anesthesia and intensive care. To date it has not been compared with the static autoregulation test for assessing graded changes in cerebral autoregulation. We compared the two tests during propofol, desflurane, and nitrous oxide anesthesia. Seven subjects were studied. For the THR test, changes in the middle artery blood flow velocity were assessed during and after a 10-s compression of the ipsilateral common carotid artery. Two indices of autoregulation--THR ratio (THRR) and strength of autoregulation (SA)--were calculated. For the test of static autoregulation, changes in the middle cerebral artery flow velocity after a phenylephrine-induces increase in mean arterial pressure were assessed, and the static rate of regulation (sROR) was calculated. The tests were performed before induction and after equilibrium at 0.5 minimum alveolar anesthetic concentration (MAC) and then at 1.5 MAC of desflurane. THRR, SA and sROR decreased significantly (P < 0.001) at 0.5 MAC and then at 1.5 MAC desflurane. CHanges in THRR and SA reflected the changes in sROR with a sensitivity of 100%.
When compared with the established test of static autoregulation, the transient hyperemic response test provides a valid method for assessing graded impairment in cerebral autoregulation.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>11429360</pmid><doi>10.1097/00000539-200107000-00034</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Algorithms Anesthesia, Inhalation Anesthesia, Intravenous Anesthetics, Inhalation Anesthetics, Intravenous Biological and medical sciences Brain Cerebrovascular Circulation - physiology Desflurane Female Homeostasis - physiology Humans Hyperemia - physiopathology Investigative techniques of hemodynamics Investigative techniques, diagnostic techniques (general aspects) Isoflurane - analogs & derivatives Male Medical sciences Middle Aged Nitrous Oxide Propofol Ultrasonography, Doppler, Transcranial |
| title | A Comparison of the Transient Hyperemic Response Test and the Static Autoregulation Test to Assess Graded Impairment in Cerebral Autoregulation During Propofol, Desflurane, and Nitrous Oxide Anesthesia |
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