Midlatency median nerve evoked responses during recovery from propofol/sufentanil total intravenous anaesthesia
Median nerve somatosensory evoked responses (MnSSER) are frequently used to monitor the integrity of the somatosensory pathway during surgery. We investigated MnSSER components during the wakeup phase from anaesthesia with propofol/sufentanil, because detailed information is lacking about the revers...
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| Veröffentlicht in: | Acta anaesthesiologica Scandinavica 2000-03, Vol.44 (3), p.313-320 |
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| creator | Rundshagen, I. Schnabel, K. Schulte Am Esch, J. |
| description | Median nerve somatosensory evoked responses (MnSSER) are frequently used to monitor the integrity of the somatosensory pathway during surgery. We investigated MnSSER components during the wakeup phase from anaesthesia with propofol/sufentanil, because detailed information is lacking about the reversibility of anaesthetic induced changes of MnSSER. The aim of the study was to document precisely the MnSSER waves in relation to the clinical awakening. The hypothesis was that anaesthetic induced MnSSER changes are reversed when the patient becomes responsive after anaesthesia.
In 20 gynaecological patients anaesthesia was maintained with propofol 8 mg kg(-1) h(-1) supplemented by bolus injections of sufentanil. MnSSER were recorded at C4' (N20, P25, N35, P45, N50) following electrical median nerve stimulation on the day before surgery, after the end of surgery during anaesthesia and every 5 min during recovery, till the patients were responsive again and able to identify a shown object.
While the primary cortical MnSSER complex N20P25 regained baseline values, the cortical latencies > or =35 ms remained prolonged (P |
| doi_str_mv | 10.1034/j.1399-6576.2000.440317.x |
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In 20 gynaecological patients anaesthesia was maintained with propofol 8 mg kg(-1) h(-1) supplemented by bolus injections of sufentanil. MnSSER were recorded at C4' (N20, P25, N35, P45, N50) following electrical median nerve stimulation on the day before surgery, after the end of surgery during anaesthesia and every 5 min during recovery, till the patients were responsive again and able to identify a shown object.
While the primary cortical MnSSER complex N20P25 regained baseline values, the cortical latencies > or =35 ms remained prolonged (P<0.001) and the amplitudes P45N50 were suppressed (P< or =0.013), when the patients were responsive after 26+/-7 min following anaesthesia. However, the amplitudes P25N35 exceeded their corresponding baseline value (P<0.01)
Persistent changes of MnSSER waves > or =35 ms reflect impaired signal processing along the somatosensory pathway following propofol/sufentanil anaesthesia when the patients are responsive again. Further studies combining MnSSER recording with distinct neuro-psychological tests are needed to define the clinical relevance of these findings.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1034/j.1399-6576.2000.440317.x</identifier><identifier>PMID: 10714847</identifier><identifier>CODEN: AANEAB</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>Adult ; Aged ; anesthesia ; Anesthesia, Intravenous ; Anesthetics, Intravenous - pharmacology ; Biological and medical sciences ; Electrodiagnosis. Electric activity recording ; Evoked Potentials, Somatosensory - drug effects ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Median Nerve - drug effects ; Median Nerve - physiology ; Median nerve somatosensory evoked responses ; Medical sciences ; Middle Aged ; Nervous system ; propofol ; Propofol - pharmacology ; Reaction Time - drug effects ; recovery ; sufentanil ; Sufentanil - pharmacology ; Time Factors</subject><ispartof>Acta anaesthesiologica Scandinavica, 2000-03, Vol.44 (3), p.313-320</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1283427$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10714847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rundshagen, I.</creatorcontrib><creatorcontrib>Schnabel, K.</creatorcontrib><creatorcontrib>Schulte Am Esch, J.</creatorcontrib><title>Midlatency median nerve evoked responses during recovery from propofol/sufentanil total intravenous anaesthesia</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description>Median nerve somatosensory evoked responses (MnSSER) are frequently used to monitor the integrity of the somatosensory pathway during surgery. We investigated MnSSER components during the wakeup phase from anaesthesia with propofol/sufentanil, because detailed information is lacking about the reversibility of anaesthetic induced changes of MnSSER. The aim of the study was to document precisely the MnSSER waves in relation to the clinical awakening. The hypothesis was that anaesthetic induced MnSSER changes are reversed when the patient becomes responsive after anaesthesia.
In 20 gynaecological patients anaesthesia was maintained with propofol 8 mg kg(-1) h(-1) supplemented by bolus injections of sufentanil. MnSSER were recorded at C4' (N20, P25, N35, P45, N50) following electrical median nerve stimulation on the day before surgery, after the end of surgery during anaesthesia and every 5 min during recovery, till the patients were responsive again and able to identify a shown object.
While the primary cortical MnSSER complex N20P25 regained baseline values, the cortical latencies > or =35 ms remained prolonged (P<0.001) and the amplitudes P45N50 were suppressed (P< or =0.013), when the patients were responsive after 26+/-7 min following anaesthesia. However, the amplitudes P25N35 exceeded their corresponding baseline value (P<0.01)
Persistent changes of MnSSER waves > or =35 ms reflect impaired signal processing along the somatosensory pathway following propofol/sufentanil anaesthesia when the patients are responsive again. Further studies combining MnSSER recording with distinct neuro-psychological tests are needed to define the clinical relevance of these findings.</description><subject>Adult</subject><subject>Aged</subject><subject>anesthesia</subject><subject>Anesthesia, Intravenous</subject><subject>Anesthetics, Intravenous - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Evoked Potentials, Somatosensory - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Median Nerve - drug effects</subject><subject>Median Nerve - physiology</subject><subject>Median nerve somatosensory evoked responses</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>propofol</subject><subject>Propofol - pharmacology</subject><subject>Reaction Time - drug effects</subject><subject>recovery</subject><subject>sufentanil</subject><subject>Sufentanil - pharmacology</subject><subject>Time Factors</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFv1DAQha0K1C6Fv4CMhLgltWM7Xh-rtmwrbeFABcdoYk_Abdbe2smq--9x1aWcRjPv08x7Q8gnzmrOhDy7r7kwpmqVbuuGMVZLyQTX9dMRWbwqb8iiSLxSXDcn5F3O96UV0phjcsKZ5nIp9YLEW-9GmDDYPd2g8xBowLRDirv4gI4mzNsYMmbq5uTD7zKwcYdpT4cUN3Sb4jYOcTzL84BhguBHOsUJRurDlGCHIc6ZQgDM0x_MHt6TtwOMGT8c6im5-3p1d3Fdrb-vbi7O15VvtJyqXlk-QOucFEaaZeNa3VtrlHMKlsY6pdD0XEk1QOOYa4VsVS-VYH2PetDilHx5WVsMPs7leLfx2eI4QsDiqNPMtFrLpoAfD-Dcl_zdNvkNpH3370MF-HwAIFsYhwTB-vyfa5ZCNs9Y9YL5POHTqwzpoWu10Kr79W3VreUPeXl7_bMT4i_vyImj</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Rundshagen, I.</creator><creator>Schnabel, K.</creator><creator>Schulte Am Esch, J.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20000301</creationdate><title>Midlatency median nerve evoked responses during recovery from propofol/sufentanil total intravenous anaesthesia</title><author>Rundshagen, I. ; Schnabel, K. ; Schulte Am Esch, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i274t-b5c1fa6dd4394982d67bcc95dd5a89cd55e9b1545fa2d0d63465b4530bbe7f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>anesthesia</topic><topic>Anesthesia, Intravenous</topic><topic>Anesthetics, Intravenous - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Evoked Potentials, Somatosensory - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Median Nerve - drug effects</topic><topic>Median Nerve - physiology</topic><topic>Median nerve somatosensory evoked responses</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>propofol</topic><topic>Propofol - pharmacology</topic><topic>Reaction Time - drug effects</topic><topic>recovery</topic><topic>sufentanil</topic><topic>Sufentanil - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rundshagen, I.</creatorcontrib><creatorcontrib>Schnabel, K.</creatorcontrib><creatorcontrib>Schulte Am Esch, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rundshagen, I.</au><au>Schnabel, K.</au><au>Schulte Am Esch, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Midlatency median nerve evoked responses during recovery from propofol/sufentanil total intravenous anaesthesia</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>44</volume><issue>3</issue><spage>313</spage><epage>320</epage><pages>313-320</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><coden>AANEAB</coden><abstract>Median nerve somatosensory evoked responses (MnSSER) are frequently used to monitor the integrity of the somatosensory pathway during surgery. We investigated MnSSER components during the wakeup phase from anaesthesia with propofol/sufentanil, because detailed information is lacking about the reversibility of anaesthetic induced changes of MnSSER. The aim of the study was to document precisely the MnSSER waves in relation to the clinical awakening. The hypothesis was that anaesthetic induced MnSSER changes are reversed when the patient becomes responsive after anaesthesia.
In 20 gynaecological patients anaesthesia was maintained with propofol 8 mg kg(-1) h(-1) supplemented by bolus injections of sufentanil. MnSSER were recorded at C4' (N20, P25, N35, P45, N50) following electrical median nerve stimulation on the day before surgery, after the end of surgery during anaesthesia and every 5 min during recovery, till the patients were responsive again and able to identify a shown object.
While the primary cortical MnSSER complex N20P25 regained baseline values, the cortical latencies > or =35 ms remained prolonged (P<0.001) and the amplitudes P45N50 were suppressed (P< or =0.013), when the patients were responsive after 26+/-7 min following anaesthesia. However, the amplitudes P25N35 exceeded their corresponding baseline value (P<0.01)
Persistent changes of MnSSER waves > or =35 ms reflect impaired signal processing along the somatosensory pathway following propofol/sufentanil anaesthesia when the patients are responsive again. Further studies combining MnSSER recording with distinct neuro-psychological tests are needed to define the clinical relevance of these findings.</abstract><cop>Copenhagen</cop><pub>Munksgaard International Publishers</pub><pmid>10714847</pmid><doi>10.1034/j.1399-6576.2000.440317.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged anesthesia Anesthesia, Intravenous Anesthetics, Intravenous - pharmacology Biological and medical sciences Electrodiagnosis. Electric activity recording Evoked Potentials, Somatosensory - drug effects Female Humans Investigative techniques, diagnostic techniques (general aspects) Median Nerve - drug effects Median Nerve - physiology Median nerve somatosensory evoked responses Medical sciences Middle Aged Nervous system propofol Propofol - pharmacology Reaction Time - drug effects recovery sufentanil Sufentanil - pharmacology Time Factors |
| title | Midlatency median nerve evoked responses during recovery from propofol/sufentanil total intravenous anaesthesia |
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