Modulation of the G Protein Regulator Phosducin by Ca2+/Calmodulin-dependent Protein Kinase II Phosphorylation and 14-3-3 Protein Binding

Phototransduction is a canonical G protein-mediated cascade of retinal photoreceptor cells that transforms photons into neural responses. Phosducin (Pd) is a Gβγ-binding protein that is highly expressed in photoreceptors. Pd is phosphorylated in dark-adapted retina and is dephosphorylated in respons...

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Veröffentlicht in:	The Journal of biological chemistry 2001-06, Vol.276 (26), p.23805-23815
Hauptverfasser:	Thulin, Craig D., Savage, Justin R., McLaughlin, Joseph N., Truscott, Steven M., Old, William M., Ahn, Natalie G., Resing, Katheryn A., Hamm, Heidi E., Bitensky, Mark W., Willardson, Barry M.
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - physiology Cattle Eye Proteins - metabolism GTP-Binding Protein Regulators Phosphoproteins - metabolism Phosphorylation Phosphoserine - metabolism Retina - metabolism Tissue Extracts Transducin - metabolism Tyrosine 3-Monooxygenase - metabolism
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