Validated HPLC method for determination of PAT-5A, an insulin sensitizing agent, in rat plasma

A high performance liquid chromatographic method for the determination of PAT-5A (a potent insulin sensitizer) using DRF-2095 (a thiazolidinedione) as internal standard (I.S.) is described. A 1:1 v/v ethylacetate and dichloromethane solvent mixture was used for extraction of PAT-5A from plasma. A Kr...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2000-03, Vol.22 (2), p.251-255
Hauptverfasser:	Mamidi, N.V.S.Rao, Kumar, V.V.S.Swaroop, Katneni, Kasiram, Chaluvadi, M.Rao, Shreeram, S, Gangadhar, S, Nataraj, B, Kishore, P.Hari, Bhushan, V, Subramaniam, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods General and cellular metabolism. Vitamins General pharmacology Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacokinetics Male Medical sciences PAT-5A-HPLC-method validation Pharmacology. Drug treatments Pyridines - blood Pyridines - pharmacokinetics Rats Rats, Wistar Reference Standards Reproducibility of Results Spectrophotometry, Ultraviolet Thiazoles - blood Thiazoles - pharmacokinetics Thiazolidinediones
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