Suppressive Effect of Tranilast on Interleukin-5 Prolonged Eosinophils Survival via Apoptosis
Tranilast has long been used clinically to treat allergic diseases such as bronchial asthma. To further clarify the antiinflammatory machanism, we examined the ability of tranilast to counteract the prolongation of eosinophil survival induced by interleukin (IL)-5. Tranilast reduced the IL-5 prolong...
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| Veröffentlicht in: | Japanese Journal of Pharmacology 2001, Vol.86(1), pp.130-133 |
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| container_title | Japanese Journal of Pharmacology |
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| creator | Cheng, Gang Ueda, Takashi Eda, Fukiko Kinjyo, Syunichi Nakajima, Hirokazu Ishii, Yoshiki Fukuda, Takeshi |
| description | Tranilast has long been used clinically to treat allergic diseases such as bronchial asthma. To further clarify the antiinflammatory machanism, we examined the ability of tranilast to counteract the prolongation of eosinophil survival induced by interleukin (IL)-5. Tranilast reduced the IL-5 prolonged survival of eosinophils at the concentration range of 30 μg/ml to 100 μg/ml. The DNA extracted from eosinophils cultured with tranilast showed signs of fragmentation that was comparable with apoptosis. Electron-microscopic analysis of activated eosinophils cultured with 100 μg/ml of tranilast also revealed morphologic features of apoptosis. These data suggest that tranilast may act in vivo on activated eosinophils to reduce inflammation in allergic diseases. |
| doi_str_mv | 10.1254/jjp.86.130 |
| format | Article |
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To further clarify the antiinflammatory machanism, we examined the ability of tranilast to counteract the prolongation of eosinophil survival induced by interleukin (IL)-5. Tranilast reduced the IL-5 prolonged survival of eosinophils at the concentration range of 30 μg/ml to 100 μg/ml. The DNA extracted from eosinophils cultured with tranilast showed signs of fragmentation that was comparable with apoptosis. Electron-microscopic analysis of activated eosinophils cultured with 100 μg/ml of tranilast also revealed morphologic features of apoptosis. These data suggest that tranilast may act in vivo on activated eosinophils to reduce inflammation in allergic diseases.</description><identifier>ISSN: 0021-5198</identifier><identifier>EISSN: 1347-3506</identifier><identifier>DOI: 10.1254/jjp.86.130</identifier><identifier>PMID: 11430466</identifier><language>eng</language><publisher>Japan: The Japanese Pharmacological Society</publisher><subject>Anti-Allergic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Cell Survival - drug effects ; Cells, Cultured ; DNA - isolation & purification ; DNA Fragmentation - drug effects ; Electrophoresis, Agar Gel ; Eosinophil ; Eosinophils - drug effects ; Humans ; Interleukin-5 - antagonists & inhibitors ; Interleukin-5 - pharmacology ; Microscopy, Electron ; ortho-Aminobenzoates - pharmacology ; Recombinant Proteins - pharmacology ; Tranilast</subject><ispartof>The Japanese Journal of Pharmacology, 2001, Vol.86(1), pp.130-133</ispartof><rights>2001 Elsevier B.V.</rights><rights>The Japanese Pharmacological Society 2001</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c699t-aa1f46d9b917912607b8d4b003b86f4486ae7457743c1b831f2656717f8c068f3</citedby><cites>FETCH-LOGICAL-c699t-aa1f46d9b917912607b8d4b003b86f4486ae7457743c1b831f2656717f8c068f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11430466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Gang</creatorcontrib><creatorcontrib>Ueda, Takashi</creatorcontrib><creatorcontrib>Eda, Fukiko</creatorcontrib><creatorcontrib>Kinjyo, Syunichi</creatorcontrib><creatorcontrib>Nakajima, Hirokazu</creatorcontrib><creatorcontrib>Ishii, Yoshiki</creatorcontrib><creatorcontrib>Fukuda, Takeshi</creatorcontrib><creatorcontrib>Department of Pulmonary Medicine and Clinical Immunology</creatorcontrib><creatorcontrib>Dokkyo University School of Medicine</creatorcontrib><title>Suppressive Effect of Tranilast on Interleukin-5 Prolonged Eosinophils Survival via Apoptosis</title><title>Japanese Journal of Pharmacology</title><addtitle>Jpn.J.Pharmacol.</addtitle><description>Tranilast has long been used clinically to treat allergic diseases such as bronchial asthma. To further clarify the antiinflammatory machanism, we examined the ability of tranilast to counteract the prolongation of eosinophil survival induced by interleukin (IL)-5. Tranilast reduced the IL-5 prolonged survival of eosinophils at the concentration range of 30 μg/ml to 100 μg/ml. The DNA extracted from eosinophils cultured with tranilast showed signs of fragmentation that was comparable with apoptosis. Electron-microscopic analysis of activated eosinophils cultured with 100 μg/ml of tranilast also revealed morphologic features of apoptosis. These data suggest that tranilast may act in vivo on activated eosinophils to reduce inflammation in allergic diseases.</description><subject>Anti-Allergic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>DNA - isolation & purification</subject><subject>DNA Fragmentation - drug effects</subject><subject>Electrophoresis, Agar Gel</subject><subject>Eosinophil</subject><subject>Eosinophils - drug effects</subject><subject>Humans</subject><subject>Interleukin-5 - antagonists & inhibitors</subject><subject>Interleukin-5 - pharmacology</subject><subject>Microscopy, Electron</subject><subject>ortho-Aminobenzoates - pharmacology</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Tranilast</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFu1DAQhiMEokvhwgOgnDggZRnHjuOcUFVtaaVKILUckeV4x62D1w52Eom3x6tsy4WDZzSa379nPhfFewJbUjfs8zCMW8G3hMKLYkMoayvaAH9ZbABqUjWkE2fFm5SGXAog7HVxRgijwDjfFD_v5nGMmJJdsNwZg3oqgynvo_LWqZQLX974CaPD-Zf1VVN-j8EF_4D7cheS9WF8tC6Vd3Nc7KJcuVhVXoxhnHIzvS1eGeUSvjvl8-LH1e7-8rq6_fb15vLittK866ZKKWIY33d9R9qO1BzaXuxZD0B7wQ1jgitsWdO2jGrSC0pMzRvektYIDVwYel58XH3HGH7PmCZ5sEmjc8pjmJNsoeOcNSILP61CHUNKEY0coz2o-EcSkEeYMsOUgssMM4s_nFzn_oD7f9ITvSy4WgW5a7XKWJz1KIcwR5_XldrwYQijkzUAkQCCHxMR-VA4BtpQIECz0ZfVaEiTesDnl1ScrHb4PNQajpefOvpRRYk-O7DVATPmxWKUSVv0Og8W85_KfbD_W_EvmzCulg</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Cheng, Gang</creator><creator>Ueda, Takashi</creator><creator>Eda, Fukiko</creator><creator>Kinjyo, Syunichi</creator><creator>Nakajima, Hirokazu</creator><creator>Ishii, Yoshiki</creator><creator>Fukuda, Takeshi</creator><general>The Japanese Pharmacological Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Suppressive Effect of Tranilast on Interleukin-5 Prolonged Eosinophils Survival via Apoptosis</title><author>Cheng, Gang ; Ueda, Takashi ; Eda, Fukiko ; Kinjyo, Syunichi ; Nakajima, Hirokazu ; Ishii, Yoshiki ; Fukuda, Takeshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c699t-aa1f46d9b917912607b8d4b003b86f4486ae7457743c1b831f2656717f8c068f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anti-Allergic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>DNA - isolation & purification</topic><topic>DNA Fragmentation - drug effects</topic><topic>Electrophoresis, Agar Gel</topic><topic>Eosinophil</topic><topic>Eosinophils - drug effects</topic><topic>Humans</topic><topic>Interleukin-5 - antagonists & inhibitors</topic><topic>Interleukin-5 - pharmacology</topic><topic>Microscopy, Electron</topic><topic>ortho-Aminobenzoates - pharmacology</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Tranilast</topic><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Gang</creatorcontrib><creatorcontrib>Ueda, Takashi</creatorcontrib><creatorcontrib>Eda, Fukiko</creatorcontrib><creatorcontrib>Kinjyo, Syunichi</creatorcontrib><creatorcontrib>Nakajima, Hirokazu</creatorcontrib><creatorcontrib>Ishii, Yoshiki</creatorcontrib><creatorcontrib>Fukuda, Takeshi</creatorcontrib><creatorcontrib>Department of Pulmonary Medicine and Clinical Immunology</creatorcontrib><creatorcontrib>Dokkyo University School of Medicine</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Gang</au><au>Ueda, Takashi</au><au>Eda, Fukiko</au><au>Kinjyo, Syunichi</au><au>Nakajima, Hirokazu</au><au>Ishii, Yoshiki</au><au>Fukuda, Takeshi</au><aucorp>Department of Pulmonary Medicine and Clinical Immunology</aucorp><aucorp>Dokkyo University School of Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppressive Effect of Tranilast on Interleukin-5 Prolonged Eosinophils Survival via Apoptosis</atitle><jtitle>Japanese Journal of Pharmacology</jtitle><addtitle>Jpn.J.Pharmacol.</addtitle><date>2001</date><risdate>2001</risdate><volume>86</volume><issue>1</issue><spage>130</spage><epage>133</epage><pages>130-133</pages><issn>0021-5198</issn><eissn>1347-3506</eissn><abstract>Tranilast has long been used clinically to treat allergic diseases such as bronchial asthma. To further clarify the antiinflammatory machanism, we examined the ability of tranilast to counteract the prolongation of eosinophil survival induced by interleukin (IL)-5. Tranilast reduced the IL-5 prolonged survival of eosinophils at the concentration range of 30 μg/ml to 100 μg/ml. The DNA extracted from eosinophils cultured with tranilast showed signs of fragmentation that was comparable with apoptosis. Electron-microscopic analysis of activated eosinophils cultured with 100 μg/ml of tranilast also revealed morphologic features of apoptosis. These data suggest that tranilast may act in vivo on activated eosinophils to reduce inflammation in allergic diseases.</abstract><cop>Japan</cop><pub>The Japanese Pharmacological Society</pub><pmid>11430466</pmid><doi>10.1254/jjp.86.130</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Allergic Agents - pharmacology Apoptosis Apoptosis - drug effects Cell Survival - drug effects Cells, Cultured DNA - isolation & purification DNA Fragmentation - drug effects Electrophoresis, Agar Gel Eosinophil Eosinophils - drug effects Humans Interleukin-5 - antagonists & inhibitors Interleukin-5 - pharmacology Microscopy, Electron ortho-Aminobenzoates - pharmacology Recombinant Proteins - pharmacology Tranilast |
| title | Suppressive Effect of Tranilast on Interleukin-5 Prolonged Eosinophils Survival via Apoptosis |
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